Lenin

Host–Guest Strategy to Reversibly Control a Chloride Carrier Process with Cyclodextrins

“…[2] Undesiredd isruption of this regulation can cause programmedc ell death or immediate cell death.T his latter event can occur from disruption of osmotic balance and cytolysis, or rupturing of the cell membrane, as water can move freely through the phospholipid bilayer. [3] Along with endo-and exocytosis, the transport of ions across ap hospholipid membrane is probably one of the first processes developed in the evolution of life.…”

“…Chloride (Cl À )i sthe most abundant anion in the extracellular environment of different organisms. [2][3][4] Its transport across cellularm embranes contributes to diversep hysiological processes.F or example, patientss uffering from cystic fibrosis illustrate dramatically the chronic consequences of too few open chloride channels,w hile individuals afflictedw ith diar-rhea demonstrate the acute effectso ft oo many open chloride channels. [5] Hence, ac ontrollable chloride transmembrane transport has potentialt herapeutic applications.…”