Lengthening of free fibular grafts for reconstruction of the residual leg length discrepancy

Zhang, Xianghong; Zhang, Tingting; Li, Zhihong; Zhang, Xiangsheng

doi:10.1186/s12891-019-2445-z

Cited by 6 publications

(2 citation statements)

References 37 publications

(42 reference statements)

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“…We had employed effective and prompt guidance of recovery exercise to 15 patients after surgery, especially after removing the fixator. Function results were ranked as excellent, good, fair, and poor based on the criteria recommend by Paley et al [15–18]…”

Section: Methodsmentioning

confidence: 99%

Bone transport with a unilateral external fixator for femoral infected nonunion after intramedullary nailing fixation

Liu

Zhang

et al. 2019

Medicine

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This is a therapeutic study to evaluate the results of femoral infected nonunion using bone transport with an external fixator after debridement and irrigation. We retrospectively reviewed 15 patients with femoral infected nonunion after intramedullary nailing fixation of fractures from October 1999 to January 2010 in our institute. There were 7 males and 8 females with an average age of 32.5 years. First, the infection was eradicated completely, and the medullary canals were continuous irrigated for 2-3 weeks. After eradicating the infection tissues, the mean amount of bone defect was 8.7 cm (range, 4.0–16.0 cm). The unilateral consecutive distraction-compression osteosynthesis technique was applied after long-time medullary cavity-wound exclusion surgery. Enumeration data was described by frequency and measurement data by mean. Bone infections were controlled in all patients except 1 patient after the first debridement and irrigation. All patients have achieved bony union without recurrence of infection during the follow-up period, the mean external fixation index was 43.4 day/cm. According to the criteria recommended by Paley, the bone results were graded as excellent in 13 (86.7%) cases and good in 2 (13.3%) cases; the functional results were graded as excellent in 6 (40.0%) cases, good in 6 (40.0%) cases and fair in 3 (20.0%) cases. In management of femoral infectious nonunion which caused by intramedullary nailing fixation, the surgery of consecutive compression-distraction osteogenesis with unilateral external fixator achieves a highly effective treatment, and the method of debridement and irrigation is a compatible choice on the phase of infection-elimination.

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Section: Methodsmentioning

confidence: 99%

Bone transport with a unilateral external fixator for femoral infected nonunion after intramedullary nailing fixation

Liu

Zhang

et al. 2019

Medicine

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“…We obtained some nonunion tissues from the enrolled patients during surgery. All atrophic nonunion were healed at last follow-up through our surgical treatment method [11,24]. This study was ethically approved by our hospital committee (No.2010-S02) and written informed consent was obtained from the patients or their legal guardians.…”

Section: Study Participantsmentioning

confidence: 99%

Existence of multilineage mesenchymal progenitor cells in human atrophic nonunion tissue

Zhang

Tang

Wan

et al. 2020

Preprint

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Background : Though the treatment of atrophic nonunion is often challenging, bone union may occurs in some patients with atrophic nonunion who underwent indirect treatment at the docking site. We aimed at explaining the reasons why does this phenomenon appear? Methods : Five patients diagnosed with atrophic nonunion were enrolled in our study. Nonunion tissues were cut into strips and cultured immediately after being obtained. We got the adherent cells from atrophic nonunion tissues, and applied the flow cytometry to assess the expression of different cell-surface protein. The research in differentiation of the adherent cells was carried out under the induction of various lineage-specific factors, and Western-blot analysis was used to measure the differentiation-related protein expression. Results : We found that the adherent cells from atrophic nonunion tissues have the characteristics similar to bone marrow stromal cells. These traits demonstrated by the flow cytometry consist of positive expression of markers CD29 and CD44, but negative expression of CD34 and CD45. The adherent cells could differentiate into osteogenic, chondrogenic, and adipogenic cells under the different lineage-specific induction factors in vitro. Alkaline Phosphatase (ALP), Col Ⅱ, osteocalcin (OC), SOX9, lipoprotein lipase (LPL) and PPAR-γ2 were high expressed, as measured by Western-blotting. Conclusions : Mesenchymal stem cells obtaining from atrophic nonunion tissues have the potential of transforming into cartilage and bone-forming cells. Furthermore, we get conclusion that the atrophic nonunion tissues play an important role in the healing process.

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Ilizarov Frame

Clarke

2023

Care Planning in Children and Young People's Nursing 2e

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Lengthening of free fibular grafts for reconstruction of the residual leg length discrepancy

Cited by 6 publications

References 37 publications

Bone transport with a unilateral external fixator for femoral infected nonunion after intramedullary nailing fixation

Bone transport with a unilateral external fixator for femoral infected nonunion after intramedullary nailing fixation

Existence of multilineage mesenchymal progenitor cells in human atrophic nonunion tissue

Ilizarov Frame

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