Length of Red Cell Unit Storage and Risk for Delirium After Cardiac Surgery

Brown, Charles H.; Grega, Maura A.; Seines, Ola A.; McKhann, Guy M.; Shah, Ashish S.; Laflam, Andrew; Savage, William; Frank, Steven M.; Hogue, Charles W.; Gottesman, Rebecca F.

doi:10.1097/01.sa.0000466256.69715.30

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…19,23,[58][59][60][61] Observational studies are, however, susceptible to prognostic differences between groups that could explain the apparent effect of RBC age. Thus, we relied exclusively on randomized trials to address the study question.…”

Section: Relation To Prior Workmentioning

confidence: 99%

Transfusion of fresher vs older red blood cells in hospitalized patients: a systematic review and meta-analysis

Alexander

Barty

Fei

et al. 2016

Blood

100

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The impact of transfusing fresher vs older red blood cells (RBCs) on patientimportant outcomes remains controversial. Two recently published large trials have provided new evidence. We summarized results of randomized trials evaluating the impact of the age of transfused RBCs. We searched MEDLINE, EMBASE, CINAHL, the Cochrane Database for Systematic Reviews, and Cochrane CENTRAL for randomized controlled trials enrolling patients who were transfused fresher vs older RBCs and reported outcomes of death, adverse events, and infection.Independently and in duplicate, reviewers determined eligibility, risk of bias, and abstracted data. We conducted random effects meta-analyses and rated certainty (quality or confidence) of evidence using the GRADE approach.

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Section: Relation To Prior Workmentioning

confidence: 99%

Transfusion of fresher vs older red blood cells in hospitalized patients: a systematic review and meta-analysis

Alexander

Barty

Fei

et al. 2016

Blood

100

View full text Add to dashboard Cite

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“…Standard blood banking practice uses a first in, first out system whereby the oldest viable pRBCs are used first, 17 and current guidelines allow the transfusion of pRBCs up to 42 days of age. 3,18,19 As pRBCs age, they undergo biochemical and morpho-logical changes known as the erythrocyte "storage lesion." 17 A particularly harmful aspect of this storage lesion is the formation of microparticles.…”

mentioning

confidence: 99%

Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation

et al. 2017

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“…In blood transfusion, red blood cells (RBCs) collected from blood donors and stored in blood banks undergo morphological, structural, and functional changes, collectively called storage lesion . Although the exact clinical consequences of storage lesion are still unclear, increasing amounts of evidence have shown a close association between RBC storage and complications after blood transfusion . Stored RBCs may deform to a greater extent in blood vessels exposed to high shear stresses than fresh RBCs do because of changes in deformability, a critical parameter of storage lesion.…”

mentioning

confidence: 99%

Analysis of red blood cells’ dynamic status in a simulated blood circulation system using an ultrahigh‐speed simultaneous framing optical electronic camera

Zhang

Zhao

et al. 2016

Cytometry Pt A

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Alterations in the morphologic and mechanical properties of red blood cells (RBCs) are considered direct indicators of blood quality. Current measures of characterizing these properties in vivo are limited by the complicated hemodynamic environment. To better evaluate the quality of fresh and stored blood, a new research platform was constructed to evaluate the hemodynamic characteristics of RBCs. The research platform consists mostly of a microfluidic chip, microscope, and ultrahigh-speed simultaneous framing optical electronic camera (USFOEC). The microfluidic chip was designed to simplify the complicated hemodynamic environment. The RBCs were diluted in erythrocyte preservative fluid and infused into the microfluidic channels. After approximately 600× magnification of using the microscope and camera, the RBCs' dynamic images were captured by the USFOEC. Eight sequential and blur-free images were simultaneously captured by the USFOEC system. Results showed that RBC deformation changed with flow velocity and stored RBCs were less sensitive to deformation (K < K ). The frozen-stored RBCs were better able to sustain hydrodynamic stress (DI = 0.128 vs. DI = 0.118) than cold-stored RBCs but more sensitive to variations in flow speed (K = 1626.2 vs. K = 1318.2). Results showed that the stored RBCs had worse deformability than fresh RBCs, but frozen-stored RBCs may incur less damage during storage than those stored at merely cold temperatures. This USFOEC imaging system can serve as a platform for direct observation of cell morphological and mechanical properties in a medium similar to a physiologic environment. © 2016 International Society for Advancement of Cytometry.

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Length of Red Cell Unit Storage and Risk for Delirium After Cardiac Surgery

Cited by 3 publications

References 29 publications

Transfusion of fresher vs older red blood cells in hospitalized patients: a systematic review and meta-analysis

Transfusion of fresher vs older red blood cells in hospitalized patients: a systematic review and meta-analysis

Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation

Analysis of red blood cells’ dynamic status in a simulated blood circulation system using an ultrahigh‐speed simultaneous framing optical electronic camera

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