Length of pressure-controlled reperfusion is critical for reducing ischaemia-reperfusion injury in an isolated rabbit lung model

Guth, Stefan; Prüfer, Diethard; Kramm, Thorsten; Mayer, Eckhard

doi:10.1186/1749-8090-2-54

Cited by 18 publications

(8 citation statements)

References 48 publications

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“…Age !55 years (n = 19) Age <55 years (n = 167) p-value early hyperperfusion of the first implanted graft and, most importantly, controlling reperfusion and ameliorating ischaemia/reperfusion injury to both implanted grafts [13,14]. Therefore, perioperative factors were similar in both groups, excluding the influence of different strategies on the long-term outcome of both groups.…”

Section: Cause Of Death (N = 61) Group a (N = 8) Group B (N = 53) P-vmentioning

confidence: 80%

Lung transplantation using donors 55 years and older: is it safe or just a way out of organ shortage?☆

Pizanis

Heckmann

Tsagakis

et al. 2010

European Journal of Cardio-Thoracic Surgery

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Donor age > or =55 years does not compromise immediate and long-term results after lung transplantation, although long-term observation of patients receiving such an organ suggests earlier lung dysfunction. Due to the rising need of organs, lungs from donors aged 55 or older have to be considered for transplantation. However, the acceptance should be based on donor lung evaluation and individual recipient needs. Long-term outcomes over 5 years need to be further investigated.

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Section: Cause Of Death (N = 61) Group a (N = 8) Group B (N = 53) P-vmentioning

confidence: 80%

Lung transplantation using donors 55 years and older: is it safe or just a way out of organ shortage?☆

Pizanis

Heckmann

Tsagakis

et al. 2010

European Journal of Cardio-Thoracic Surgery

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“…There is exhausting evidence highlighting the importance of controlled organ reperfusion, and the length of controlled reperfusion is critical. [14][15][16][17] In addition, one of the main features in donor organ injury is a significant endothelial leakage. 18 By reducing the blood flow through a predamaged pulmonary vascular bed, fluid extravasation and further impairment of pulmonary function can be avoided.…”

Section: Discussionmentioning

confidence: 99%

Bilateral lung transplantation on intraoperative extracorporeal membrane oxygenator: An observational study

Höetzenecker

Benazzo

Störk

et al. 2020

The Journal of Thoracic and Cardiovascular Surgery

105

112

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“…Several studies have demonstrated the benefits of controlled reperfusion for early graft function. [15][16][17][18] Additionally, with a routine application of ECMO in LTx, extremely low numbers of reperfusion edema have been reported. 19,20 Because this is especially true for the later time points, the discrepancies between best and worst case scenarios in our study are less profound at t72.…”

Section: Discussionmentioning

confidence: 99%

Interobserver variability impairs radiologic grading of primary graft dysfunction after lung transplantation

Schwarz

Muckenhuber

Benazzo

et al. 2019

The Journal of Thoracic and Cardiovascular Surgery

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Objectives: The current score for primary graft dysfunction after lung transplantation relies heavily on chest radiographs, and radiologic judgment can make the difference between the lowest (primary graft dysfunction 0) and the highest (primary graft dysfunction 3) grade. This study aimed to evaluate interobserver variability of the scoring of postoperative chest radiographs and its impact on primary graft dysfunction grades in a large single-center cohort.Methods: We retrospectively analyzed 497 lung transplantations performed between January 2010 and July 2016 at the Medical University of Vienna. Five trained thoracic radiologists were asked to independently examine postoperative chest radiographs performed at 0 to 6 hours, 24 hours, 48 hours, and 72 hours after arrival at the intensive care unit. Interobserver variability was calculated using Fleiss' kappa (k) statistics.Results: A total of 1988 chest radiographs were evaluated. Consensus among all 5 radiologists was found in only 826 cases (43.0%). At 0 to 6 hours and 24 hours, only a moderate agreement was found among the 5 radiologists (k ¼ 0.456 and 0.456, respectively), and agreement was even worse at 48 and 72 hours (k ¼ 0.405 and k ¼ 0.409). On the basis of this high interobserver variability, best and worst case scenarios were calculated leading to primary graft dysfunction 3 rates of 8.4% versus 28.4% at 0 to 6 hours, 1.8% versus 4.8% at 24 hours, 2.0% versus 5.3% at 48 hours, and 0.2% versus 3.1% at 72 hours. A high recipient body mass index and size-reduced transplants were found to be factors associated with higher rates of interobserver variability. Conclusions:The substantial interobserver variability found in this retrospective analysis underlines the difficulty to adequately grade post-transplant organ function. Future revisions of the primary graft dysfunction grading should take this problem into consideration.

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Length of pressure-controlled reperfusion is critical for reducing ischaemia-reperfusion injury in an isolated rabbit lung model

Cited by 18 publications

References 48 publications

Lung transplantation using donors 55 years and older: is it safe or just a way out of organ shortage?☆

Lung transplantation using donors 55 years and older: is it safe or just a way out of organ shortage?☆

Bilateral lung transplantation on intraoperative extracorporeal membrane oxygenator: An observational study

Interobserver variability impairs radiologic grading of primary graft dysfunction after lung transplantation

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