Length difference of multi‐walled carbon nanotubes generates differential cytotoxic responses

Thi, Nhuan Do; Kim, Suho; Kwak, Minjeong; Lee, Tae Geol; Jo, Dong-Gyu; Lee, Sang‐Won; Kim, Se-Hwa

doi:10.1002/jat.4132

Cited by 6 publications

(3 citation statements)

References 42 publications

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“…Aspect ratio of asbestos fibers turned out to be one of the reasons for increased cancerogenicity [204]. Length variations in CNTs point in the same direction [205]. A provoking discussion on this issue is reported by Fadeel et al [70], which definitely reinforces the need for biomedical safety assessments of especially carbon nanomaterials in parallel to advancing the fabrication methodologies.…”

Section: Potential Cytotoxicity Of Some Carbon Nanomaterialsmentioning

confidence: 94%

Carbon-based neural electrodes: promises and challenges

et al. 2021

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Neural electrodes are primary functional elements of neuroelectronic devices designed to record neural activity based on electrochemical signals. These electrodes may also be utilized for electrically stimulating the neural cells, such that their response can be simultaneously recorded. In addition to being medically safe, the electrode material should be electrically conductive and electrochemically stable under harsh biological environments. Mechanical flexibility and conformability, resistance to crack formation and compatibility with common microfabrication techniques are equally desirable properties. Traditionally, (noble) metals have been the preferred for neural electrode applications due to their proven biosafety and a relatively high electrical conductivity. Carbon is a recent addition to this list, which is far superior in terms of its electrochemical stability and corrosion resistance. Carbon has also enabled 3D electrode fabrication as opposed to the thin-film based 2D structures. One of carbon’s peculiar aspects is its availability in a wide range of allotropes with specialized properties that render it highly versatile. These variations, however, also make it difficult to understand carbon itself as a unique material, and thus, each allotrope is often regarded independently. Some carbon types have already shown promising results in bioelectronic medicine, while many others remain potential candidates. In this topical review, we first provide a broad overview of the neuroelectronic devices and the basic requirements of an electrode material. We subsequently discuss the carbon family of materials and their properties that are useful in neural applications. Examples of devices fabricated using bulk and nano carbon materials are reviewed and critically compared. We then summarize the challenges, future prospects and next-generation carbon technology that can be helpful in the field of neural sciences. The article aims at providing a common platform to neuroscientists, electrochemists, biologists, microsystems engineers and carbon scientists to enable active and comprehensive efforts directed towards carbon-based neuroelectronic device fabrication.

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Section: Potential Cytotoxicity Of Some Carbon Nanomaterialsmentioning

confidence: 94%

Carbon-based neural electrodes: promises and challenges

et al. 2021

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“…Do et al found that the internalization of MWCNTs led to the cytotoxicity and mitochondrial dysfunction in human coronary artery smooth muscle cells. Smaller MWCNTs were more cytotoxic compared with larger MWCNTs, indicating a role of physicochemical properties of MWCNTs (Do et al, 2021). Similarly, our group also showed composition‐dependent cytotoxicity of NPs to human aortic smooth muscle cells, that only ZnO NPs but not TiO 2 or Ag NPs induced cytotoxicity.…”

Section: Adverse Vascular Effects Of Nmsmentioning

confidence: 99%

Potential roles of Kruppel‐like factors in mediating adverse vascular effects of nanomaterials: A review

Cao

2021

J of Applied Toxicology

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The development of nanotechnology leads to the exposure of human beings to nanomaterials (NMs), and there is a health concern about the adverse vascular effects of NMs. Current data from epidemiology, controlled human exposure, and animal studies suggested that exposure to NMs could induce cardiopulmonary effects. In support of in vivo findings, in vitro studies showed that direct contact of vascular cells with NMs could induce endothelial cell (EC) activation and promote macrophage foam cell formation, although only limited studies showed that NMs could damage vascular smooth muscle cells and promote their phenotypic switch. It has been proposed that NMs induced adverse vascular effects via different mechanisms, but it is still necessary to understand the upstream events. Kruppel‐like factors (KLFs) are a set of C2H2 zinc finger transcription factors (TFs) that can regulate various aspects of vascular biology, but currently, the roles of KLF2 in mediating the adverse vascular effects of NMs have gained little attention by toxicologists. This review summarized current knowledge about the adverse vascular effects of NMs and proposed the potential roles of KLFs in mediating these effects based on available data from toxicological studies as well as the current understanding about KLFs in vascular biology. Finally, the challenges in investigating the role of KLFs in vascular toxicology were also summarized. Considering the important roles of KLFs in vascular biology, further studies are needed to understand the influence of NMs on KLFs and the downstream events.

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“…Indeed, most of the studies used VSMCs as an in vitro model to investigate the cytotoxic potential of NMs, such as calcifying NMs, 33 metal-based NMs 34,35 and CNTs. 36,37 Regarding graphene oxide, two recent studies reported that they exhibited relatively high biocompatibility in VSMCs and thus were suitable for biomedical purposes. 38,39 However, besides acting as the cells constructing the walls of blood vessels, VSMCs have also been revealed as pivotal cells involved in the regulation of pathophysiology of blood vessels as endothelial cells.…”

Section: Introductionmentioning

confidence: 99%