Length and sequence effect on the B-Z transition of [d(A-T)n]2 oligonucleotide induced by a cationic porphyrin

Shin, Jong Heon; Hwang, Yoon Mo; Kim, Seog K.

doi:10.1016/j.bpc.2016.06.007

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…[4][5][6][7][8] Somem olecules have been reported that can induce aB-Z DNA conformational transfer. [9][10][11][12][13][14][15][16][17][18] For example, in the presence of al ow concentration of [Co(NH 3 ) 6 ] 3 + ,B-DNA conformationally transforms into Z-DNA. [11] More interestingly,w ith an increasing concentration of [Co(NH 3 ) 6 ] 3 + ,D NA turns into ah igh-orderc ompacts tructure.…”

Section: Introductionmentioning

confidence: 99%

Interfering with DNA High‐Order Structures using Chiral Ruthenium(II) Complexes

Zou

Rees

et al. 2017

Chemistry A European J

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In this work, it was found that DNA can undergo B-Z transformational changes and compaction in the presence of DNA intercalators such as ruthenium(II) polypyridyl complexes. The link between B-Z transition and condensation is weak but can be strengthened under certain circumstances with slight alterations to the structures of the ruthenium(II) complexes. Here, following on from previous research, this work reports a series of ruthenium(II) complexes with imidazophenanthroline ligands, which vary in size and planarity. The complexes exhibit distinct effects on DNA structures, ranging from little impact to the transformation of DNA secondary structures to the formation of higher-order DNA structures. Further studies on DNA morphological changes induced by chiral ruthenium(II) complexes are observed by atomic force microscopy and transmission electron microscopy.

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Section: Introductionmentioning

confidence: 99%

Interfering with DNA High‐Order Structures using Chiral Ruthenium(II) Complexes

Zou

Rees

et al. 2017

Chemistry A European J

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Relationship between the photoinduced electron transfer and binding modes of a pyrene–porphyrin dyad to DNA

Lee

Han

Park

et al. 2017

Phys. Chem. Chem. Phys.

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The binding modes of a pyrene-porphyrin dyad, (1-pyrenyl)-tris(N-methyl-p-pyridino)porphyrin (PyTMpyP), to DNA and its photophysical properties have been investigated using various spectroscopic techniques. The circular dichroism (CD) spectrum of PyTMpyP bound to DNA (PyTMpyP-DNA) showed one negative and two positive bands in the Soret region. The CD signal in the pyrene absorption region was positive. The shape of the CD spectrum does not support an intercalative binding mode of TMpyP, which would typically afford a negative CD band in the absence of the pyrene moiety. Linear dichroism (LD) experiments revealed a very small signal in the Soret region, which also challenges the intercalation of TMpyP into DNA. Upon excitation of the pyrene moiety, the emission intensity of porphyrin in aqueous solution was quenched due to a photoinduced electron transfer (PET) process between the pyrenyl and porphyrin moieties. On the other hand, the emission of porphyrin was markedly enhanced upon binding to DNA, as the PET process from the excited pyrene moiety to TMpyP was suppressed when bound to DNA. The PET process occurs in the timescale of 65 ps, and could be detected by femtosecond transient absorption spectroscopic methods. Two fluorescence decay times were observed for PyTMpyP in aqueous solution (0.78 and 4.8 ns). Both decay times increased upon binding to DNA owing to environment and/or conformational changes in PyTMpyP. The driving force (ΔG) of the PET process was evaluated under conditions of minor and major groove binding. The PET process and photophysical properties of the PyTMpyP dyad were concluded to be influenced by the binding mode.

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C8-Guanine modifications: effect on Z-DNA formation and its role in cancer

Vongsutilers¹,

Gannett

2018

Org. Biomol. Chem.

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Base modifications are known to affect the structure and function of DNA. C8-guanine adducts from various carcinogenic compounds have been shown to be potent Z-DNA inducers. Hence, it has been hypothesized that Z-DNA plays a role in cancer and other genetic diseases. In this comprehensive review, Z-DNA and the effect of prevalent C8-guanine adducts on the B-Z transition are addressed. The discoveries of Z-DNA binding proteins including ADAR1, E3L, DLM1, and PKZ have suggested the relevance of Z-DNA in living systems. In addition, increasing evidence on the Z-DNA connection to gene transcription and inhibition reveals potential biological functions of the left-handed DNA. Finally, C8-guanine adducts that promote Z-DNA formation can be used as a tool to explore the Z-DNA function and its role in carcinogenesis.

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Length and sequence effect on the B-Z transition of [d(A-T)n]2 oligonucleotide induced by a cationic porphyrin

Cited by 4 publications

References 20 publications

Interfering with DNA High‐Order Structures using Chiral Ruthenium(II) Complexes

Interfering with DNA High‐Order Structures using Chiral Ruthenium(II) Complexes

Relationship between the photoinduced electron transfer and binding modes of a pyrene–porphyrin dyad to DNA

C8-Guanine modifications: effect on Z-DNA formation and its role in cancer

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