Lenalidomide in the management of eosinophilic dermatosis of hematological malignancy

Sato‐Sano, Marcelo; Teixeira, Solange Pistori; Vargas, Juliano Cordova; Baiocchi, Otavio C. G.; Enokihara, Mílvia Maria Simões e Silva; Gomes, Elimar Elias; Batista, Mariana Dias

doi:10.1111/1346-8138.14916

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…B cells are an almost universal finding in PCSM-LPD and can account for up to 60% of the cell population 13–19,21–26 ; these include not only small B cells but also immunoblasts that are scattered and typically surrounded by clusters of atypical CD4 + cells expressing PD-1 in a pseudorosette pattern, an observation that is a hallmark of the disease. Indeed, the follicular T-helper phenotype of the T cells is believed to be responsible for the induction of this B-cell hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

“…3,[14][15][16][17] Diagnostic problems that have been highlighted include a misdiagnosis of a B-cell-usually marginal zone-lymphoma due to the high prevalence of admixed B cells 13,14,18 and, rarely, a high number of CD30(+) cells that can raise concern over a CD30(+) lymphoproliferative disease. 19,20 B cells are an almost universal finding in PCSM-LPD and can account for up to 60% of the cell population [13][14][15][16][17][18][19][21][22][23][24][25][26] ; these include not only small B cells but also immunoblasts that are scattered and typically surrounded by clusters of atypical CD4 + cells expressing PD-1 in a pseudorosette pattern, an observation that is a hallmark of the disease. Indeed, the follicular T-helper phenotype of the T cells is believed to be responsible for the induction of this B-cell hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

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Prominent Blasts in Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoproliferative Disorder. A Reconsideration of Diagnostic Criteria

Bakr

Wain

Wong

et al. 2021

The American Journal of Dermatopathology

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Primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder (PCSM-LPD), recently downgraded from a T-cell lymphoma, is a poorly characterized histopathological entity. Presenting as a solitary lesion that often grows rapidly, it may raise suspicion for a cutaneous B-cell lymphoma. However, classically, the dermal lymphoid proliferation is predominantly CD4 + with a follicular T-helper profile and a smaller B-cell fraction. Diagnostic uncertainty may arise when B cells are present in large numbers, a B-cell clone is present, or large cell populations are seen. To meet the diagnostic criterion of PCSM-LPD, large cells should not constitute more than 30% of the infiltrate. The 2 cases presented in this article caused diagnostic uncertainty owing to the observation of high numbers of large cells and in one case the presence of a B-cell clone, on the background of otherwise typical clinicopathological features of PCSM-LPD. We review the literature specifically regarding the prevalence of large cell populations and their immunophenotypic characteristics and in light of this discuss whether a current diagnostic criterion should be reconsidered.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prominent Blasts in Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoproliferative Disorder. A Reconsideration of Diagnostic Criteria

Bakr

Wain

Wong

et al. 2021

The American Journal of Dermatopathology

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“…Eosinophilic dermatoses are mainly associated with B CLL and other B lymphoproliferative diseases, such as mantle cell lymphoma, acute lymphoblastic leukemia, and large B-cell lymphoma, but also with T lymphomas and acute leukemias. 6 , 28 …”

Section: Nonspecific Skin Lesions Related To Systemic Hematologic Mal...mentioning

confidence: 99%

“…Concomitant treatment of the underlying hematologic disease may contribute to improvement of the clinical picture. 28 , 33 …”

Section: Nonspecific Skin Lesions Related To Systemic Hematologic Mal...mentioning

confidence: 99%

Dermatological manifestations of hematologic neoplasms. Part II: nonspecific skin lesions/paraneoplastic diseases

Souza¹,

Amorim²,

Sousa³

et al. 2023

Anais Brasileiros de Dermatologia

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“…Immunosuppressants such as methotrexate and azathioprine are also effective and allow a reduction in the dose of systemic corticosteroids needed to control the disease and relieve symptoms [103]. One case report supports the efficacy of lenalidomide [126].…”

Section: Eosinophilic Dermatoses Of Haematological Malignanciesmentioning

confidence: 99%

Immune-Mediated Dermatoses in Patients with Haematological Malignancies: A Comprehensive Review

et al. 2020

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Haematological malignancies induce important alterations of the immune system, which account for the high frequency of autoimmune complications observed in patients. Cutaneous immune-mediated diseases associated with haematological malignancies encompass a heterogeneous group of dermatoses, including, among others, neutrophilic and eosinophilic dermatoses, autoantibody-mediated skin diseases, vasculitis and granulomatous dermatoses. Some of these diseases, such as paraneoplastic pemphigus, are associated with an increased risk of death; others, such as eosinophilic dermatoses of haematological malignancies, run a benign clinical course but portend a significant negative impairment on a patient's quality of life. In rare cases, the skin eruption reflects immunological alterations associated with an unfavourable prognosis of the associated haematological disorder. Therapeutic management of immune-mediated skin diseases in patients with haematological malignancies is often challenging. Systemic corticosteroids and immunosuppressive drugs are considered frontline therapies but may considerably augment the risk of serious infections. Indeed, developing a specific targeted therapeutic approach is of crucial importance for this particularly fragile patient population. This review provides an up-to-date overview on the immune-mediated skin diseases most frequently encountered by patients with onco-haematological disorders, discussing new pathogenic advances and therapeutic options on the horizon.

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Lenalidomide in the management of eosinophilic dermatosis of hematological malignancy

Cited by 5 publications

References 13 publications

Prominent Blasts in Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoproliferative Disorder. A Reconsideration of Diagnostic Criteria

Prominent Blasts in Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoproliferative Disorder. A Reconsideration of Diagnostic Criteria

Dermatological manifestations of hematologic neoplasms. Part II: nonspecific skin lesions/paraneoplastic diseases

Immune-Mediated Dermatoses in Patients with Haematological Malignancies: A Comprehensive Review

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