Lemierre Syndrome in Adolescent with Active Ulcerative Colitis

Unić, Josipa; Kovačić, Matea; Jakovljević, Gordana; Batoš, Ana Tripalo; Grmoja, Tonći; Hojsak, Iva

doi:10.5223/pghn.2018.21.3.214

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…The use of anticoagulation therapy is still controversial. However, most researchers believe that anticoagulation should be used in cases of thrombophilia (10) or extensive and severe thrombosis not responding to antibiotics (6). In our case, we observed a complete recanalization of the hepatic vein without anticoagulation therapy.…”

Section: Discussionmentioning

confidence: 47%

An Unusual Variant of Lemierre’s Syndrome with Multiple Abscesses and Hepatic Vein Thrombosis

et al. 2020

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Introduction: Lemierre’s syndrome is an uncommon, life-threatening disease that develops as a severe complication of oropharyngeal infection. However, this syndrome has also been reported during anaerobic septicemia, originating from diverse sources of infection, such as the gastrointestinal system. The diagnosis of this syndrome remains challenging, and is often prompted by the detection of Fusobacterium necrophorum in blood culture, rather than with clinical signs or symptoms. Case Presentation: A previously healthy 38-year-old woman was hospitalized for a 6-day history of fever, watery diarrhea, and vomiting. Physical examination of the patient showed fever, pharyngitis, and diffuse abdominal tenderness. Laboratory investigations revealed elevated inflammatory markers, and two blood cultures revealed Fusobacterium necrophorum. An abdominal ultrasound showed a liver abscess and hepatic vein thrombosis. The thoracoabdominal and cerebral computed tomography scan confirmed the results of the abdominal ultrasound. It additionally revealed bilateral lung nodules and a parietal brain abscess. The patient’s general condition and her laboratory test results, improved after receiving treatment with ceftriaxone and metronidazole. She received antibiotics for three months, without anticoagulation therapy. Repeated computed tomography scans showed a resolution of the liver, pulmonary, and brain abscesses, as well as the recanalization of the hepatic vein. Conclusions: Lemierre’s syndrome emerges as a result of septic illness and liver abscesses in case of gastrointestinal symptoms despite the lack of common presentation.

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Section: Discussionmentioning

confidence: 47%

An Unusual Variant of Lemierre’s Syndrome with Multiple Abscesses and Hepatic Vein Thrombosis

et al. 2020

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Lung abscess as a complication of Lemierre Syndrome in adolescents: a single center case reports and review of the literature

Venditto,

Ferrante,

Caccin

et al. 2023

Ital J Pediatr

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Background Fusobacterium necrophorum is an anaerobic, gram-negative, non-motile, filamentous, non-spore forming bacillus found in the oral cavity, gastrointestinal tract, and female genital tract, responsible of a rare disease named Lemierre Syndrome, characterized by septic thrombophlebitis of the internal jugular vein, which mainly affects previously healthy adolescents and young adults; some risk factors are reported, as smoking or primary viral or bacterial infection leading to the disruption of mucosa. The syndrome originates commonly from an upper respiratory infection such as pharyngotonsillitis, acute otitis media, cervical lymphadenitis, sinusitis, or odontogenic abscess, and may result in multiorgan metastasis, more frequently leading to pulmonary complications, especially lung abscesses. Case presentation We describe two cases of adolescents with atypical Lemierre Syndrome evaluated in a tertiary care center, one with a confirmed infection by Fusobacterium necrophorum and one with a presumptive diagnosis based on clinical features, who developed lung abscesses needing a prolonged antibiotic course and hospitalization. Of interest, both were user of electronic cigarette, configuring a possible new risk factor. The proper diagnosis of Lemierre Syndrome is often difficult to establish, so a high degree of suspicion is needed, especially in the case of lung abscesses in otherwise healthy adolescents. Conclusion The current study will contribute to providing insight into Lemierre Syndrome clinical presentation and management in adolescents, promoting awareness for a rare but potentially fatal disease. Moreover, it suggests a possible relationship between Lemierre syndrome and the use of electronic cigarette, that should be investigated by future studies.

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Lemierre’s syndrome in pediatric population

Górny,

Rosa,

Siwołowska

et al. 2024

Pol Otorhino Rev

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WPROWADZENIE: Zespół Lemierre’a jest rzadkim, potencjalnie śmiertelnym powikłaniem infekcji górnych dróg oddechowych, występującym głównie u młodych, wcześniej zdrowych osób. Definiowany jest jako poanginowa posocznica z towarzyszącą zakrzepicą żyły szyjnej wewnętrznej oraz ropniami w narządach odległych. Jego charakterystyczne objawy to pogorszenie stanu zdrowia w 4-7. dobie leczenia infekcji pierwotnej, nawrót gorączki oraz jednostronny obrzęk i bolesność szyi. CELE PRACY: Analiza opisanych w literaturze w ciągu ostatnich 30 lat przypadków pediatrycznych zespołu Lemierre’a. Przedstawienie własnych doświadczeń i obserwacji klinicznych dzieci leczonych z powodu zespołu Lemierre’a. WNIOSKI: Zespół Lemierre’a jest w większości przypadków powikłaniem ostrego zapalenia gardła i ostrego zapalenia ucha środkowego. Pomimo występowania ciężkich powikłań ze strony narządów odległych oraz rozległych zmian zakrzepowych w naczyniach żylnych, w większości przypadków w populacji pediatrycznej udaje się uzyskać całkowite wyleczenie. Leczenie zespołu Lemierre’a opiera się przede wszystkim na szerokospektralnej antybiotykoterapii, a w niektórych przypadkach również na interwencji chirurgicznej i terapii przeciwzakrzepowej. Aktualnie nie ma jednolitych wytycznych dotyczących stosowania leczenia przeciwzakrzepowego, szczególnie w populacji pediatrycznej.

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Lemierre Syndrome in Adolescent with Active Ulcerative Colitis

Cited by 3 publications

References 12 publications

An Unusual Variant of Lemierre’s Syndrome with Multiple Abscesses and Hepatic Vein Thrombosis

An Unusual Variant of Lemierre’s Syndrome with Multiple Abscesses and Hepatic Vein Thrombosis

Lung abscess as a complication of Lemierre Syndrome in adolescents: a single center case reports and review of the literature

Lemierre’s syndrome in pediatric population

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