Lemierre's syndrome due to Fusobacterium necrophorum

Kuppalli, Krutika; Livorsi, Daniel J; Talati, Naasha J; Osborn, Melissa

doi:10.1016/s1473-3099(12)70089-0

Cited by 235 publications

(313 citation statements)

References 74 publications

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“…To date, there are no published data reporting the relationship between acute pancreatitis and LS. As other reports suggested that septic emboli could metastasize to any part of the body through the blood stream,2, 3, 7, 8 there was a possibility that the patient's acute pancreatitis was caused by the metastatic septic emboli as a part of LS. The learning points from this case are that LS and acute pancreatitis can occur simultaneously and, most importantly, assuming one diagnosis without paying attention to the symptoms not compatible with it (in our case, oropharyngeal symptoms not compatible with acute pancreatitis) can lead to the delayed diagnosis of LS.…”

Section: Discussionmentioning

confidence: 92%

“…The IJV thrombophlebitis presents as unilateral cervical tenderness that mimics lymphadenopathy. Metastatic septic emboli are common in lung (85%) and large joints (16–26%) 2, 3. Other metastatic diseases include soft tissue abscess, cutaneous lesions, pyomyositis, splenic and liver abscess, osteomyelitis, endocarditis, pericarditis, renal abscess, hemolytic uremic syndrome, and central nervous system complications including encephalopathy, meningitis, cerebral infarctions, epidural abscess, and brain abscess 3, 7, 8.…”

Section: Discussionmentioning

confidence: 99%

“…Next, there is invasion of the lateral pharyngeal wall and thrombophlebitis of the internal jugular vein. This is then followed by bacteremia and septic emboli to vital organs, which can lead to metastatic abscesses, as well as other fatal complications 2, 3, 4…”

Section: Introductionmentioning

confidence: 99%

“…In this modern era, the incidence is approximately 0.6–3.2 persons per million per year 2, 3, 6. It is most common in young adults aged between 15 and 24 years 2.…”

Section: Introductionmentioning

confidence: 99%

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Lemierre's syndrome presented with acute pancreatitis

García

Ito

2017

Acute Medicine & Surgery

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CaseLemierre's syndrome is a rare clinical condition that is characterized by infected internal jugular vein thrombosis with metastatic septicemia. The most common causative agent is Fusobacterium necrophorum. A previously healthy 37‐year‐old woman presented to our emergency department with nausea, vomiting, and diarrhea. She was admitted to the general practice unit with a diagnosis of acute pancreatitis then was subsequently transferred to the intensive care unit due to shock. Physical examination revealed tenderness on right side of the neck. Blood cultures were remarkable for F. necrophorum. Clinical symptoms led to subsequent ultrasound and computed tomography scan of the neck, confirming internal jugular vein thrombosis.OutcomeThe patient was treated with antibiotics for 6 weeks. Anticoagulation therapy was initiated.ConclusionWe report a case of Lemierre's syndrome that presented as acute pancreatitis. The high index of suspicion of this disease is important for early diagnosis.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…In this modern era, the incidence is approximately 0.6–3.2 persons per million per year 2, 3, 6. It is most common in young adults aged between 15 and 24 years 2.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Lemierre's syndrome presented with acute pancreatitis

García

Ito

2017

Acute Medicine & Surgery

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“…The mechanism of internal jugular vein involvement is not entirely clear, however various theories have been put forward such as hematogenous/lymphatic spread or local invasion. Once thrombophlebitis sets in, it can lead to systemic bacteremia and distant metastasis[5].…”

Section: Discussionmentioning

confidence: 99%

Some neck swellings are serious; a case of Lemierre’s Syndrome

Ghani

Hamid

Raza

et al. 2017

Journal of Community Hospital Internal Medicine Perspectives

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Lemierre’s syndrome also termed post-anginal septicemia, is a disease characterized by internal jugular septic thrombophlebitis leading to Fusobacterium septicemia with multiple metastatic foci following an oropharyngeal infection. Diagnosis and management is challenging and can result in fatal consequences due to potential multisystem involvement and multiple complications. We describe here a case of Lemierre’s syndrome with multifocal pneumonia, acute renal failure and protracted course of illness over forty days with successful recovery. A brief overview of literature is also presented.

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