Leitlinie Neurodermitis [atopisches Ekzem; atopische Dermatitis]

Werfel, Thomas; Aberer, Werner; Ahrens, Frank; Matthias, A. Marjorie; Biedermann, Tilo; Diepgen, Thomas; Fölster‐Holst, Regina; Gieler, Uwe; Heratizadeh, Annice; Kahle, Julia; Alexander, Kapp; Nast, Alexander; Nemat, Katja; Ott, Hagen; Przybilla, Bernhard; Roecken, Martin; Schlaeger, Martin; Peter, Schmid-Grendelmeier; Schmitt, Jochen; Schwennesen, Thomas; Staab, Doris; Worm, Margitta

doi:10.1111/ddg.12884

Cited by 22 publications

(2 citation statements)

References 464 publications

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“…According to the stepwise systematic search procedure and study selection process described in the methods, we identified 19 19‐37 publications (including 20 RCTs) from 4 38‐44 included guidelines; 14 45‐58 publication (including 15 RCTs) from 12 included systematic reviews 59‐70 (Step 1 in Figure 1) and 18 RCTs from the systematic literature search for RCTs 71‐88 (Step 2 in Figure 1). The systematic review by Nankervis et al 61 searched for systemic treatments in general; therefore, we defined the end of this search period as the starting point for our second systematic literature search for RCTs (with an overlap of 6 months, these are included in the search period in Figure 1/ Step 2).…”

Section: Resultsmentioning

confidence: 99%

Systemic treatments in the management of atopic dermatitis: A systematic review and meta‐analysis

Siegels

Heratizadeh

Abraham

et al. 2020

Allergy

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Background As an evidence resource for the currently planned European Academy of Allergy and Clinical Immunology (EAACI) clinical practice guideline “systemic treatment of atopic dermatitis (AD),” we critically appraised evidence on systemic treatments for moderate‐to‐severe AD. Methods We systematically identified randomized controlled trials (RCTs) investigating the safety and efficacy of systemic treatments for AD up to February 2020. Primary efficacy outcomes were clinical signs, AD symptoms and health‐related quality of life. Primary safety outcomes included cumulative incidence rates for (serious) adverse events. Trial quality was assessed applying the Cochrane Risk of Bias Tool 2.0. Meta‐analyses were conducted where appropriate. Results 50 RCTs totalling 6681 patients were included. Trial evidence was identified for apremilast, azathioprine (AZA), baricitinib, ciclosporin A (CSA), corticosteroids, dupilumab, interferon‐gamma, intravenous immunoglobulins (IVIG), mepolizumab, methotrexate (MTX), omalizumab, upadacitinib and ustekinumab. Meta‐analyses were indicated for the efficacy of baricitinib [EASI75 RD 0.16, 95% CI (0.10;0.23)] and dupilumab [EASI75, RD 0.37, 95% CI (0.32;0.42)] indicating short‐term (ie 16‐week treatment) superiority over placebo. Furthermore, efficacy analyses of AZA and CSA indicated short‐term superiority over placebo; however, nonvalidated scores were used and can therefore not be compared to EASI. Conclusion The most robust, replicated high‐quality trial evidence is present for the efficacy and safety of dupilumab for up to 1 year in adults. Robust trial evidence was further revealed for AZA, baricitinib and CSA. Methodological restrictions led to limited evidence‐based conclusions for all other systemic treatments. Head‐to‐head trials with novel systemic treatments are required to clarify the future role of conventional therapies.

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Section: Resultsmentioning

confidence: 99%

Systemic treatments in the management of atopic dermatitis: A systematic review and meta‐analysis

Siegels

Heratizadeh

Abraham

et al. 2020

Allergy

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“…AD therapy includes a basic therapy in the form of careful skin care and cleansing, which should help to strengthen the skin barrier and prevent irritation 27 . The therapeutic options for symptom exacerbation have long been limited to topical corticosteroids, calcineurin inhibitors, and systemic immunosuppressants.…”

Section: Discussionmentioning

confidence: 99%

Can crowdsourced data help to optimize atopic dermatitis treatment? Comparing web search data and environmental data in Germany

Mick

Tizek

Schielein

et al. 2021

Acad Dermatol Venereol

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Background Atopic dermatitis (AD) is one of the most common chronic skin diseases worldwide, showing various manifestations and having a severe impact on quality of life. As previous studies demonstrated, internet search analysis can help identify public interest in diseases and possible influencing factors on search behavior. Objective To identify AD‐related topics of interest in Germany using internet search volume. Methods Google Ads Keyword Planner was used to identify AD‐related search terms including their search volume in Germany on a national level as well as in 16 selected cities from January 2016 to December 2019. Identified keywords were qualitatively analyzed, and temporal trends as well as the influence of seasonal and environmental factors on search volume were assessed. Results Overall, 1222 AD‐related search terms with a search volume of 8 842 360 searches were identified. An increase from 2016 to 2019 and seasonal peaks from January to April of each year were observed. Nationwide, the search volume correlated with mean monthly temperature and sun duration. With increasing temperature and sun duration, a significant decrease in search queries was observed. The most populated cities showed the lowest number of searches per 100 000 inhabitants (Berlin, Hamburg, and Munich). In the eight categories formed (comorbidities, general, influential factors, localization, stage of life, symptoms/severity, therapy/information, and questions on AD), the highest proportion of search queries were assigned to the category “therapy/information” in most cities. In this category, a focus on the topics of “alternative medicine” and “home remedies“ could be observed. Conclusion The overall high and increasing search volume indicates a high interest in AD‐related topics, especially regarding treatment and disease education. Information provided by internet search volume analyses can optimize AD therapy and patient‐centered care by providing insight into patient needs and predicting potential climatic trigger factors.

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Leitlinie Neurodermitis [atopisches Ekzem; atopische Dermatitis]

Cited by 22 publications

References 464 publications

Systemic treatments in the management of atopic dermatitis: A systematic review and meta‐analysis

Systemic treatments in the management of atopic dermatitis: A systematic review and meta‐analysis

Can crowdsourced data help to optimize atopic dermatitis treatment? Comparing web search data and environmental data in Germany

Other Topical Therapies (Dyes, Tanning Agents, Tars, CO2)

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