Leisure-time sedentary behaviors are differentially associated with all-cause dementia regardless of engagement in physical activity

Raichlen, David A.; Klimentidis, Yann C.; Sayre, M. Katherine; Bharadwaj, Pradyumna K.; Lai, Mark H. C.; Wilcox, Rand R.; Alexander, Gene E.

doi:10.1073/pnas.2206931119

Cited by 31 publications

(20 citation statements)

References 70 publications

(96 reference statements)

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“…These study results complement previous work suggesting increased time in sedentary behavior is associated with reduced cognitive performance, 20 and that some types of leisure-time sedentary behavior (eg, cognitively passive TV watching) are associated with increased dementia risk. 7…”

Section: Discussionmentioning

confidence: 99%

“…Previous work found that self-reported leisure-time sedentary behaviors were associated with risk of developing all-cause dementia, and the direction of the risk depended on the activity done while sedentary (ie, cognitively passive TV watching vs cognitively active computer use) . However, a recent study using accelerometer-derived sitting time did not find an association between sedentary behaviors and incident dementia in a sample of older women (n = 1277) …”

Section: Introductionmentioning

confidence: 92%

“…Previous work found that self-reported leisure-time sedentary behaviors were associated with risk of developing allcause dementia, and the direction of the risk depended on the activity done while sedentary (ie, cognitively passive TV watching vs cognitively active computer use). 7 However, a recent study using accelerometer-derived sitting time did not find an association between sedentary behaviors and incident dementia in a sample of older women (n = 1277). 8 In the present study, a machine learning algorithm was applied to wearable accelerometry data from a large cohort of older adults in the UK Biobank to derive an objective measure of time spent sedentary and to determine any associations between sedentary behaviors and incident dementia.…”

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confidence: 93%

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Sedentary Behavior and Incident Dementia Among Older Adults

Raichlen,

Aslan,

Sayre

et al. 2023

JAMA

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ImportanceSedentary behavior is associated with cardiometabolic disease and mortality, but its association with dementia is unclear.ObjectiveTo investigate whether accelerometer-assessed sedentary behavior is associated with incident dementia.Design, Setting, and ParticipantsA retrospective study of prospectively collected data from the UK Biobank including 49 841 adults aged 60 years or older without a diagnosis of dementia at the time of wearing the wrist accelerometer and living in England, Scotland, or Wales. Follow-up began at the time of wearing the accelerometer (February 2013 to December 2015) and continued until September 2021 in England, July 2021 in Scotland, and February 2018 in Wales.ExposuresMean daily sedentary behavior time (included in the primary analysis) and mean daily sedentary bout length, maximum daily sedentary bout length, and mean number of daily sedentary bouts (included in the secondary analyses) were derived from a machine learning–based analysis of 1 week of wrist-worn accelerometer data.Main Outcome and MeasuresIncident all-cause dementia diagnosis from inpatient hospital records and death registry data. Cox proportional hazard models with linear and cubic spline terms were used to assess associations.ResultsA total of 49 841 older adults (mean age, 67.19 [SD, 4.29] years; 54.7% were female) were followed up for a mean of 6.72 years (SD, 0.95 years). During this time, 414 individuals were diagnosed with incident all-cause dementia. In the fully adjusted models, there was a significant nonlinear association between time spent in sedentary behavior and incident dementia. Relative to a median of 9.27 hours/d for sedentary behavior, the hazard ratios (HRs) for dementia were 1.08 (95% CI, 1.04-1.12, P &lt; .001) for 10 hours/d, 1.63 (95% CI, 1.35-1.97, P &lt; .001) for 12 hours/d, and 3.21 (95% CI, 2.05-5.04, P &lt; .001) for 15 hours/d. The adjusted incidence rate of dementia per 1000 person-years was 7.49 (95% CI, 7.48-7.49) for 9.27 hours/d of sedentary behavior, 8.06 (95% CI, 7.76-8.36) for 10 hours/d, 12.00 (95% CI, 10.00-14.36) for 12 hours/d, and 22.74 (95% CI, 14.92-34.11) for 15 hours/d. Mean daily sedentary bout length (HR, 1.53 [95% CI, 1.03-2.27], P = .04 and 0.65 [95% CI, 0.04-1.57] more dementia cases per 1000 person-years for a 1-hour increase from the mean of 0.48 hours) and maximum daily sedentary bout length (HR, 1.15 [95% CI, 1.02-1.31], P = .02 and 0.19 [95% CI, 0.02-0.38] more dementia cases per 1000 person-years for a 1-hour increase from the mean of 1.95 hours) were significantly associated with higher risk of incident dementia. The number of sedentary bouts per day was not associated with higher risk of incident dementia (HR, 1.00 [95% CI, 0.99-1.01], P = .89). In the sensitivity analyses, after adjustment for time spent in sedentary behavior, the mean daily sedentary bout length and the maximum daily sedentary bout length were no longer significantly associated with incident dementia.Conclusions and RelevanceAmong older adults, more time spent in sedentary behaviors was significantly associated with higher incidence of all-cause dementia. Future research is needed to determine whether the association between sedentary behavior and risk of dementia is causal.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

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confidence: 93%

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Sedentary Behavior and Incident Dementia Among Older Adults

Raichlen,

Aslan,

Sayre

et al. 2023

JAMA

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“…A recent study has reported that time spent watching TV was associated with increased risks of incident dementia and time spent using a computer was associated with decreased risks of incident dementia. Reducing the cognitively passive SB times (i.e., TV) and increasing time spent on cognitively active SB activities (i.e., computer) may be effective behavioral modification targets for reducing the risk of dementia [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Sedentary Behavior during Leisure Time and Excessive Weight in Chinese Children, Adolescents, and Adults

Li²,

et al. 2023

Nutrients

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(1) Background: Sedentary behavior is increasing in all age groups and is one of the most common lifestyles that is a risk factor for overweight and obesity; however, few studies have evaluated the impact of leisure-time sedentary behavior on overweight and obesity. This study aims to examine the distribution characteristics of different leisure-time sedentary behaviors and their effects on excessive weight in different age groups in the Chinese population to provide evidence for the development of behavioral interventions. (2) Methods: This study utilizes data from the 2004 to 2011 China Health and Nutrition Survey (CHNS). Participants ranged in age from 6 to 18 years or older and were from China. Weight and height were measured in the physical examination, and the sedentary behavior times during leisure periods were collected by using a questionnaire. Logistic regression models were performed for association analyses. (3) Results: A total of 36,169 participants were included in this study. The impact of screen-based sedentary leisure time on excessive weight is greater in middle-aged and older adults. For middle-aged adults, sedentary time periods spent on the Internet or video games were found to be significantly and positively associated with excessive weight (OR, 1.122, 95% CI, 1.005–1.253). In addition, for older adults, sedentary time periods spent watching television or videos were found to be significantly and positively associated with excessive weight (OR, 1.065, 95% CI, 1.035–1.095). (4) Conclusions: This study helps grasp the target population and provide evidence for the development of behavioral intervention guidelines.

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“… In einer weiteren US-amerikanischen Studie zeigte sich erneut, dass das Sitzen vor dem Fernsehapparat, nicht jedoch das Sitzen vor dem Computer, die Wahrscheinlichkeit einer Demenz erhöht 36 . …”

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Zehn Jahre Digitale Demenz

Spitzer¹

2022

Nervenheilkunde

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Leisure-time sedentary behaviors are differentially associated with all-cause dementia regardless of engagement in physical activity

Cited by 31 publications

References 70 publications

Sedentary Behavior and Incident Dementia Among Older Adults

Sedentary Behavior and Incident Dementia Among Older Adults

Association between Sedentary Behavior during Leisure Time and Excessive Weight in Chinese Children, Adolescents, and Adults

Zehn Jahre Digitale Demenz

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