Leisure Time Physical Activity Is Associated With Poor Glycemic Control in Type 1 Diabetic Women

Wadén, Johan; Tikkanen, Heikki; Forsblom, Carol; Fagerudd, Johan; Pettersson-Fernholm, Kim; Lakka, Timo A.; Riska, Mikael; Groop, Per‐Henrik

doi:10.2337/diacare.28.4.777

Cited by 78 publications

(64 citation statements)

References 37 publications

(12 reference statements)

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“…In CONCLUSIONS -Low LTPA was associated with a higher prevalence of the metabolic syndrome, supporting our previous findings on LTPA and insulin sensitivity in type 1 diabetes (14). Due to the cross-sectional study design, LTPA could have been reduced by exercise-limiting factors associated with the metabolic syndrome.…”

Section: Research Design Andsupporting

confidence: 73%

“…METHODS -Using a cross-sectional study design, 1,028 type 1 diabetic patients from the FinnDiane Study (3,14) with data on leisure-time physical activity (LTPA) and metabolic syndrome were studied. Patients with end-stage renal disease and/or cardiovascular events were excluded.…”

Section: Research Design Andmentioning

confidence: 99%

“…LTPA (as MET h/week) was assessed by a validated 12-month questionnaire (16), and patients were grouped as sedentary, moderately active, or active as previously described (14). The PPAR␥ Pro12Ala (rs1801282) polymorphism was studied from 840 of the 1,028 patients using an ABI Prism 7900 Sequence Detection System (Applied Biosystems, Foster City, CA).…”

Section: Research Design Andmentioning

confidence: 99%

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Leisure-Time Physical Activity Is Associated With the Metabolic Syndrome in Type 1 Diabetes

Wadén

Thorn²,

Forsblom³

et al. 2007

Diabetes Care

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Section: Research Design Andsupporting

confidence: 73%

Section: Research Design Andmentioning

confidence: 99%

Section: Research Design Andmentioning

confidence: 99%

See 1 more Smart Citation

Leisure-Time Physical Activity Is Associated With the Metabolic Syndrome in Type 1 Diabetes

Wadén

Thorn²,

Forsblom³

et al. 2007

Diabetes Care

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“…Patients with type 1 diabetes were recruited from the Finnish Diabetic Nephropathy (FinnDiane) study [27]. The healthy male volunteers were medical students.…”

Section: Study Groupsmentioning

confidence: 99%

Acute hyperglycaemia rapidly increases arterial stiffness in young patients with type 1 diabetes

et al. 2007

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Aims/hypothesis Augmentation index (AIx) and pulse wave velocity (PWV), both measures of arterial stiffness, constitute risk factors for cardiovascular disease. Notably, hyperglycaemia during an acute cardiovascular event is associated with poor prognosis. The objective of this study was to investigate whether acute hyperglycaemia increases arterial stiffness in patients with type 1 diabetes and in healthy subjects. Methods Twenty-two male patients with type 1 diabetes and thirteen healthy men, who were age-matched nonsmokers and without any diabetic complications, underwent a 120 min hyperglycaemic clamp (15 mmol/l). AIx was calculated to assess arterial stiffness. Before and during the clamp, carotid-radial (brachial) and carotid-femoral (aortic) PWV was measured. Results At baseline there was a difference in the AIx between patients with type 1 diabetes and healthy volunteers (−5±2.7 vs −20±2.8%, p<0.05). Acute hyperglycaemia rapidly increased AIx in patients with type 1 diabetes (−5±2.7 vs 8±2.5%, p<0.001) and healthy volunteers (−20±2.8 vs 6±8.8%, p<0.001). Brachial PWV increased during acute hyperglycaemia in patients with type 1 diabetes (7.1±1.2 vs 8.0±1.0 m/s, p<0.001), but not in healthy men (7.4±1.7 vs 7.3±1.4 m/s, NS). Conclusions/interpretation Acute hyperglycaemia increases the stiffness of intermediate-sized arteries and resistance arteries in young patients with type 1 diabetes and consequently emphasises the importance of strict daily glycaemic control. No change was observed in aortic PWV during the clamp, indicating that acute hyperglycaemia does not affect the large vessels.

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“…We previously showed that sedentary women with type 1 diabetes have worse glycaemic control than those who achieve the general recommendations for regular physical activity [3]. However, no prospective epidemiological studies have assessed the level of physical activity and the development of diabetic microvascular complications in patients with type 1 diabetes.…”

Section: Introductionmentioning

confidence: 99%

Leisure-time physical activity and development and progression of diabetic nephropathy in type 1 diabetes: the FinnDiane Study

et al. 2015

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Aims/hypothesis The aim of this study was to assess how physical activity predicts the development and progression of diabetic nephropathy in patients with type 1 diabetes. Methods This prospective study (follow-up time 6.4 ± 3.1 years) included 1,390 patients (48.5% men, mean age 37.0±12.4 years, duration of diabetes 20.4±12.3 years) participating in the nationwide multicentre Finnish Diabetic Nephropathy (FinnDiane) Study. Leisure-time physical activity (LTPA) was assessed using a validated self-report questionnaire. Renal status was defined according to standard clinical cut-off values for urinary AER. Results The total amount of LTPA was not associated with progression in renal status. For the intensity of LTPA, however, the 10 year cumulative progression rate was 24.0% (95% CI 18.8, 28.8), 13.5% (95% CI 10.3, 16.6) or 13.1% (95% CI 10.3%, 16.6%; p=0.01) of the patients with low, moderate or high intensity LTPA. This pattern was similar to that for the development of de novo microalbuminuria. Corresponding progression rates for LTPA frequency of <1, 1-2 or >2 sessions/week was 24.7% (95% CI 18.3, 30.7), 14.7% (95% CI 10.2, 19.0) or 12.6% (95% CI 9.4, 15.7), respectively ( p=0.003). Conclusions/interpretation This study demonstrates for the first time in a prospective setting the relationship between physical activity and the risk of diabetic nephropathy in patients with type 1 diabetes. The data suggest that physical activity, and in particular its intensity, may have an impact Johan Wadén and Heidi K. Tikkanen contributed equally to this study.Electronic supplementary material The online version of this article (doi:10.1007/s00125-015-3499-6) contains peer-reviewed but unedited supplementary material, which is available to authorised users.

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Leisure Time Physical Activity Is Associated With Poor Glycemic Control in Type 1 Diabetic Women

Cited by 78 publications

References 37 publications

Leisure-Time Physical Activity Is Associated With the Metabolic Syndrome in Type 1 Diabetes

Leisure-Time Physical Activity Is Associated With the Metabolic Syndrome in Type 1 Diabetes

Acute hyperglycaemia rapidly increases arterial stiffness in young patients with type 1 diabetes

Leisure-time physical activity and development and progression of diabetic nephropathy in type 1 diabetes: the FinnDiane Study

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