Leisure Activities and the Risk of Dementia in the Elderly

Verghese, Joe; Lipton, Richard B.; Katz, Mindy J.; Hall, Charles B.; Derby, Carol A.; Kuslansky, Gail; Ambrose, Anne Felicia; Sliwinski, Martin J.; Buschke, Herman

doi:10.1056/nejmoa022252

Cited by 1,610 publications

(1,278 citation statements)

References 38 publications

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“…For instance, animals with enriched environments are protected against cognitive impairment 28, 30 . Additionally in clinical settings it is also observed that clinical manifestations may not correlate with the neuropathological burden on postmortem examination 6, 31-33 , implying that the cognitive reserve may serve as a buffer against the Alzheimer’s disease neuropathological burden. Since MCI is considered to be a prodromal state to Alzheimer’s disease, one can invoke the cognitive reserve theory to explain the inverse association between cognitive activities and the odds of having MCI.…”

Section: Discussionmentioning

confidence: 99%

Engaging in Cognitive Activities, Aging, and Mild Cognitive Impairment: A Population-Based Study

Geda¹,

Topazian²,

Lewis³

et al. 2011

Journal of Neuropsychiatry

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We investigated whether engaging in cognitive activities is associated with mild cognitive impairment (MCI) in a cross-sectional study derived from an ongoing population-based study of normal cognitive aging and MCI in Olmsted County, Minnesota. A random sample of 1321 non-demented study participants ages 70 to 89 (n = 1124 cognitively normal persons and n = 197 subjects with MCI) was interviewed about the frequency of cognitive activities carried out in late life (within one year of the date of interview). Computer activities [OR (95% CI) = 0.50 (0.36, 0.71); p < .0001)], craft activities such as knitting, quilting, etc. [0.66 (0.47, 0.93); p = 0.019)], playing games [0.65 (0.47, 0.90); p = 0.010)], and reading books [0.67 (0.49, 0.94); p = 0.019)] were associated with decreased odds of having MCI. Social activities such as traveling were marginally significant [0.71 (0.51, 1.00); p = 0.050)]. Even though the point estimates for reading magazines, playing music, artistic activities, and group activities were associated with reduced odds of having MCI, none reached statistical significance. We could not expect to observe any difference between the two groups on the variable of reading newspapers since almost identical proportions of the two groups (97.4% of normals and 97.5% of the MCI group) were engaged in reading newspapers on a regular basis.

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Section: Discussionmentioning

confidence: 99%

Engaging in Cognitive Activities, Aging, and Mild Cognitive Impairment: A Population-Based Study

Geda¹,

Topazian²,

Lewis³

et al. 2011

Journal of Neuropsychiatry

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“…Additionally, physical activity level was measured by asking participants how many days per month (0-30) did they participate in exercise or sports? (Verghese et al 2003).…”

Section: Clinical Assessment and Mild Parkinsonian Signsmentioning

confidence: 99%

Contributions of mild parkinsonian signs to gait performance in the elderly

Allali

Mahoney

2014

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Mild parkinsonian signs (MPS) and gait abnormalities are common in aging, but the association between MPS and objective gait measures is not established in the elderly. This study aims to identify the link between MPS and quantitative gait measures, as well as to determine the pathogenesis of MPS in nondemented community-dwelling older adults without idiopathic Parkinson's disease or other parkinsonian syndromes. Three hundred seventy-four non-demented older adults (mean age, 76.44±6.71 years, 57 % women) participated in this study, where comprehensive neurological and medical assessments were conducted. We defined MPS based on the presence of any one of bradykinesia, rigidity, or rest tremor. Velocity and spatial, temporal, and variability gait parameters were recorded using an instrumented walkway. The associations of MPS and gait parameters as well as the relationship of individual MPS with medical illnesses were assessed with linear regressions controlling for key covariates. Participants with MPS walked slower and with disturbed spatial and variability components of gait compared to those without MPS. Bradykinesia was associated with worse spatial and variability gait parameters. This association was only significant for axial bradykinesia, but not for the presence of bradykinesia in the limbs. Cerebrovascular disease (β=.20, p<.01) was associated with bradykinesia, whereas cardiovascular disease (β=.15, p<.05) was associated with rigidity. Among MPS, bradykinesia but not rigidity or tremor was associated with worse quantitative gait performance in older adults. Cerebrovascular disease, a preventable condition, was specifically associated with bradykinesia.

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“…Leisure activities involving contact with people were found to protect against cognitive decline and dementia (Fabrigoule et al 1995;Verghese et al 2003), reduce disability risk (Mendes de Leon et al 2003) and increase survival . However, few studies have examined the effects of activities centered on family life, which are the most common activities among the elderly in familycentered societies, such as those in southern Europe, Africa, Asia and Latin America.…”

Section: Introductionmentioning

confidence: 99%

Disability and social ties: comparative findings of the CLESA study

et al. 2005

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The associations between prevalence, incidence and recovery from activities of daily living (ADL) disability and social ties among community-dwelling persons over 65 in Finland, The Netherlands and Spain are examined. Data were harmonized in the CLESA study. The baseline sample was composed of 3,648 subjects between 65 and 85 years old, living in Finland, The Netherlands and Spain. Disability in four activities of daily living was determined at baseline and at follow-up. Social participation, number of family ties and presence of friends were added to obtain a social ties index. Logistic regressions were fitted to the prevalence, incidence and recovery data to estimate the associations between disability and social ties, adjusting for education, comorbidity and self-rated health. The modifying effects of country, age and sex were tested in all models. For every country, the social ties index, having friends and social participation were negatively associated with ADL disability prevalence. ADL incidence was negatively related to the number of family ties, with a stronger relationship in Spain than in The Netherlands or Finland. ADL recovery was associated with the social ties index. No age or gender differences in these associations were found. Social ties appear to generate a beneficial effect on the maintenance and restoration of ADL function. While social ties play an important role in maintaining and restoring function in all three countries, family ties appear to generate a stronger effect on protection from disability incidence than does social participation, and the strength of this effect varies by culture.

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Leisure Activities and the Risk of Dementia in the Elderly

Cited by 1,610 publications

References 38 publications

Engaging in Cognitive Activities, Aging, and Mild Cognitive Impairment: A Population-Based Study

Engaging in Cognitive Activities, Aging, and Mild Cognitive Impairment: A Population-Based Study

Contributions of mild parkinsonian signs to gait performance in the elderly

Disability and social ties: comparative findings of the CLESA study

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