Leishmaniosis cutánea en Colombia y género

Vélez, Iván Darío; Hendrickx, Erik; Robledo, Sara M.; Agudelo, Sonia del Pilar

doi:10.1590/s0102-311x2001000100018

Cited by 53 publications

(36 citation statements)

References 6 publications

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“…In addition, ethno-medical studies in indigenous and farming communities in Latin America show extensive and empirical use of locally applied caustic agents (gunpowder, hot sugar cane, silver nitrate, petroleum, and battery acid) or cauterization with hot metallic instruments, such as spoons or the edge of an ax, which they apply over the lesions, achieving, in many cases, lesion scarring 14,33,34 .…”

Section: Discussionmentioning

confidence: 99%

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Thermoterapy effective and safer than miltefosine in the treatment of cutaneous leishmaniasis in Colombia

López

Cruz

Godoy

et al. 2013

Rev. Inst. Med. trop. S. Paulo

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SUMMARYIn Colombia, pentavalent antimonials and miltefosine are the drugs of choice for the treatment of cutaneous leishmaniasis; however, their toxicity, treatment duration, (treatment adherence problems), cost, and decreased parasite sensitivity make the search for alternative treatments of American cutaneous leishmaniasis necessary. Based on the results found in a controlled, open, randomized, phase III clinical trial, the efficacy and safety of miltefosine was compared to that of thermotherapy for the treatment of cutaneous leishmaniasis in Colombia. Adult patients from the Colombian army participated in the study; they received either 50 mg of miltefosine three times per day for 28 days by the oral route (n = 145) or a thermotherapy (Thermomed ® ) application of 50 ºC for 30 seconds over the lesion and surrounding area (n = 149). Both groups were comparable with respect to their sociodemographic, clinical, and parasitological characteristics. The efficacy of miltefosine by protocol and by intention to treat was 70% (85/122 patients) and 69% (85/145 patients), respectively. The adverse effects were primarily gastrointestinal for miltefosine and pain at the lesion site after treatment for thermotherapy. No statistically significant difference was found in the efficacy analysis (intention to treat and protocol) between the two treatments. ClinicalTrials.gov: NCT00471705.

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Section: Discussionmentioning

confidence: 99%

“…In these populations, it is estimated that only 10% of patients with CL receive treatment with antimonials, and even then, the incidence of ML is very low. In addition, systemic treatment does not guarantee the absence of ML 14,33,34,35 .…”

Section: Discussionmentioning

confidence: 99%

Thermoterapy effective and safer than miltefosine in the treatment of cutaneous leishmaniasis in Colombia

López

Cruz

Godoy

et al. 2013

Rev. Inst. Med. trop. S. Paulo

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“…Esto se demuestra por la inexistencia de diferencias estadísticamente significativas en la encuesta de intradermorreacción de Montenegro, que establece la prevalencia de infección (datos no mostrados) en la región. Sin embargo, las mujeres siguen sin acceder a los servicios de salud, en este caso, por su propia percepción de los sistemas de salud, como los describió Vélez et al 21 .…”

Section: Sobre El Sistema De Saludunclassified

Estudio de los conocimientos, actitudes y prácticas de la leishmaniasis: evidencias del olvido estatal en el Darién Colombiano

et al. 2014

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“…It is caused by L. infantum transmitted by the bite of the phlebotomine sand flies Lutzomia evansi (Caribbean coast) and Lu. longipalpis (Magdalena River Valley) 4,8,31 .…”

Section: Introductionmentioning

confidence: 99%

Two cases of visceral leishmaniasis in Colombia resistant to meglumine antimonial treatment

Vélez

Colmenares

Muñoz

2009

Rev. Inst. Med. trop. S. Paulo

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SUMMARYVisceral leishmaniasis (VL) affects over 500 000 people worldwide each year. The disease occurs in the Mediterranean basin, Central and South America and is caused by Leishmania infantum (syn L. chagasi). VL is an endemic disease in Colombia, particularly along the Caribbean coast and the Magdalena River Valley and 90% of VL cases occur in children under the age of five. The first line of treatment is chemotherapy with pentavalent antimonial compounds, including sodium stibogluconate (Pentostam®) and meglumine antimoniate (Glucantime®). These compounds are the ones most used in Colombia, at a dose of 20 mg/kg/day for 28 days. Nevertheless resistance of L. infantum to pentavalent antimonials is becoming an important problem.No cases of VL resistant to pentavalent antimonial compounds have previously been reported from Colombia. This report describes the two cases of VL resistance to antimonial compounds in a girl and a boy who did not respond to previous treatment with Pentacarinat® and Glucantime® regimens but were treated successfully with liposomal amphotericin B. Based on our findings, we recommend liposomal amphotericin B as the first line of treatment for VL due to its low toxicity, shorter administration period and the low price obtained by WHO.

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Leishmaniosis cutánea en Colombia y género

Abstract: Leishmaniasis in Colombia has traditionally been seen as a health risk for adult males, as they become infected when they enter the vector

Cited by 53 publications

References 6 publications

Thermoterapy effective and safer than miltefosine in the treatment of cutaneous leishmaniasis in Colombia

Thermoterapy effective and safer than miltefosine in the treatment of cutaneous leishmaniasis in Colombia

Estudio de los conocimientos, actitudes y prácticas de la leishmaniasis: evidencias del olvido estatal en el Darién Colombiano

Two cases of visceral leishmaniasis in Colombia resistant to meglumine antimonial treatment

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