Leishmanioses cutanées d’aspect clinique inhabituel chez trois patients diabétiques

Chiheb, Soumiya; Oudrhiri, L.; Zouhair, K.; Abdallaoui, Maha Soussi; Riyad, Myriam; Benchikhi, H.

doi:10.1016/j.annder.2012.05.013

Cited by 10 publications

(4 citation statements)

References 6 publications

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“…Many host factors have been associated with the development of skin or mucosal lesions and worsening of TL, as well as the appearance of unusual clinical presentations of cutaneous leishmaniasis. For example, patients infected with L. major and affected by diabetes mellitus type I showed more extensive and vegetative lesions ( Chiheb et al, 2012 ). In another study, an association of the nutritional status and clinical and therapeutical evolution in adults and the elderly with ATL was observed ( Oliveira et al, 2013 ).…”

Section: The Host Point Of Viewmentioning

confidence: 99%

The Binomial Parasite-Host Immunity in the Healing Process and in Reactivation of Human Tegumentary Leishmaniasis

2018

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Leishmaniasis is a vector-borne infectious disease caused by different species of protozoa from the Leishmania genus. Classically, the disease can be classified into two main clinical forms: Visceral (VL) and Tegumentary (TL) leishmaniasis. TL is a skin/mucosal granulomatous disease that manifests mainly as cutaneous localized or disseminated ulcers, papules diffusely distributed, mucosal lesions or atypical lesions. Once the etiology of the infection is confirmed, treatment can take place, and different drugs can be administered. It has already been shown that, even when the scar is clinically evident, inflammation is still present in the native tissue, and the decrease of the inflammatory process occurs slowly during the 1st years after clinical healing. The maintenance of residual parasites in the scar tissue is also well documented. Therefore, it is no longer a surprise that, under some circumstances, therapeutic failure and/or lesion reactivation occurs. All over the years, an impressive amount of data on relapses, treatment resistance and lesion reactivation after healing has been collected, and several factors have been pointed out as having a role in the process. Different factors such as Leishmania species, parasite variability, Leishmania RNA virus 1, parasite load, parasite persistence, age, nutritional status, gender, co-morbidities, co-infection, pregnancy, immunosuppression, lesion duration, number and localization of lesions, drug metabolism, irregular treatment and individual host cellular immune response were described and discussed in the present review. Unfortunately, despite this amount of information, a conclusive understanding remains under construction. In addition, multifactorial influence cannot be discarded. In this context, knowing why leishmaniasis has been difficult to treat and control can help the development of new approaches, such as drugs and immunotherapy in order to improve healing maintenance. In this sense, we would like to highlight some of the findings that may influence the course of Leishmania infection and the therapeutic response, with an emphasis on TL.

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Section: The Host Point Of Viewmentioning

confidence: 99%

The Binomial Parasite-Host Immunity in the Healing Process and in Reactivation of Human Tegumentary Leishmaniasis

2018

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“…In our Moroccan experience atypical and unusual clinical aspects of LC are observed especially with Leishmaniatropica [15].…”

Section: Discussionmentioning

confidence: 99%

Unusual presentation of cutaneous Leishmaniasis in pregnancy: A case report

Chakiri¹,

Gallouj²,

Mernissi³

et al. 2017

Our Dermatol Online

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“…Both types of diabetes are associated with secondary complications, such as cardiovascular diseases, retinopathy, nephropathy, neuropathy, reduced wound healing and increased susceptibility to infections, particularly in the skin [ 1–7 ]. The recent increase in the burden of diabetes [ 8 , 9 ] and reports of abnormal cases of cutaneous leishmaniasis (CL) in individuals with diabetes [ 10 , 11 ] led us to investigate the consequences of association of these diseases. The main goal of this study is to evaluate the influence of diabetes and its inflammatory mediators in the outcome of Leishmania braziliensis skin infection.…”

Section: Introductionmentioning

confidence: 99%

Unbalanced production of LTB ₄ /PGE ₂ driven by diabetes increases susceptibility to cutaneous leishmaniasis

Bonyek-Silva

Nunes

Santos

et al. 2020

Emerging Microbes & Infections

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Poorly controlled diabetes mellitus leads to several comorbidities, including susceptibility to infections. Hyperglycemia increases phagocyte responsiveness, however immune cells from people with diabetes show inadequate antimicrobial functions. We and others have shown that aberrant production of leukotriene B 4 (LTB 4) is detrimental to host defense in models of bacterial infection. Here, we will unveil the consequences of high glucose in the outcome of Leishmania braziliensis skin infection in people with diabetes and determine the role of LTB 4 in human phagocytes. We show that diabetes leads to higher systemic levels of LTB 4 , IL-6 and TNF-α in cutaneous leishmaniasis. Only LTB 4 correlated with blood glucose levels and healing time in diabetes comorbidity. Skin lesions of people with leishmaniasis and diabetes exhibit increased neutrophil and amastigote numbers. Monocyte-derived macrophages from these individuals showed higher L. braziliensis loads, reduced production of Reactive Oxygen Species and unbalanced LTB 4 /PGE 2 ratio. Our data reveal a systemic inflammation driven by diabetes comorbidity in opposition to a local reduced capacity to resolve L. braziliensis infection and a worse disease outcome.

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Leishmanioses cutanées d’aspect clinique inhabituel chez trois patients diabétiques

Cited by 10 publications

References 6 publications

The Binomial Parasite-Host Immunity in the Healing Process and in Reactivation of Human Tegumentary Leishmaniasis

The Binomial Parasite-Host Immunity in the Healing Process and in Reactivation of Human Tegumentary Leishmaniasis

Unusual presentation of cutaneous Leishmaniasis in pregnancy: A case report

Unbalanced production of LTB ₄ /PGE ₂ driven by diabetes increases susceptibility to cutaneous leishmaniasis

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Leishmanioses cutanées d’aspect clinique inhabituel chez trois patients diabétiques

Cited by 10 publications

References 6 publications

The Binomial Parasite-Host Immunity in the Healing Process and in Reactivation of Human Tegumentary Leishmaniasis

The Binomial Parasite-Host Immunity in the Healing Process and in Reactivation of Human Tegumentary Leishmaniasis

Unusual presentation of cutaneous Leishmaniasis in pregnancy: A case report

Unbalanced production of LTB 4 /PGE 2 driven by diabetes increases susceptibility to cutaneous leishmaniasis

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Unbalanced production of LTB ₄ /PGE ₂ driven by diabetes increases susceptibility to cutaneous leishmaniasis