Leishmaniose cutanée à Leishmania infantum associée à une infection par le VIH

Diatta, B.A.; Diallo, Mamadou Alpha; Diadié, S.; Faye, Babacar; Ndiaye, M.; Hakim, H.; Diallo, S.; Seck, B.; Niang, Seydou; Kane, Adama; Dieng, Mame Thierno

doi:10.1016/j.annder.2016.03.014

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…In the district of Mont-Rolland, Thiès, Senegal, HVL Western blot seroprevalence from a survey conducted in the entire population was 23% (73/315); but symptomatic cases were not diagnosed [20]. Recently L. infantum- related cutaneous leishmaniasis was described in an HIV-infected child in Senegal [21]. This case of human L. infantum -cutaneous leishmaniasis [21], CVL reported in the Mont Roland area [5], and the possibility of a unique and recent introduction of Mediterranean L. infantum strain in Senegal [22] provide evidence that L. infantum is present in the West African region.…”

Section: Discussionmentioning

confidence: 99%

Visceral Leishmaniasis in West Africa: Clinical Characteristics, Vectors, and Reservoirs

Koné

Niare

Piarroux

et al. 2019

Journal of Parasitology Research

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Visceral leishmaniasis (VL) is the most serious form of human leishmaniasis. VL is understudied in West Africa. The increasing number of patients at-risk, including persons living with HIV and other chronic immunosuppressive diseases, and likely underreporting of VL related to diagnostic challenges advocate for review of existing data to understand VL regional epidemiology. Our review aims to describe the clinical characteristics and epidemiology of Human VL (HVL) in West Africa. We conducted a literature search to identify peer-reviewed articles and grey literature sources using the search terms “Visceral leishmaniasis West Africa”, “Leishmania donovani West Africa”; and “Leishmania infantum West Africa”. Thirty published articles report HVL from seven countries, including The Gambia, Niger, Nigeria, Ivory Coast, Togo, Burkina Faso, and Guinea Bissau. Three countries report cases of Canine Visceral Leishmaniasis (CVL), including The Gambia, Senegal, and Burkina Faso. Niger, Nigeria, and Ivory Coast report the greatest number of HVL cases. As VL is present in West Africa, active surveillance, increased diagnostic capacity, and studies of vectors and reservoirs are essential to better understand VL epidemiology in the region.

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Section: Discussionmentioning

confidence: 99%

Visceral Leishmaniasis in West Africa: Clinical Characteristics, Vectors, and Reservoirs

Koné

Niare

Piarroux

et al. 2019

Journal of Parasitology Research

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“…More recent studies have shown that the circulation of L. infantum was well established in this past outbreak and that more than 30% of dogs and 20% of humans were serologically positive [ 3 , 4 ]. Furthermore, authors have shown the presence of L. infantum in cutaneous leishmaniasis in a child with HIV [ 5 ]. Thus, several factors make Senegalese leishmaniasis an atypical and worrisome focus: (1) an unusual location of L. infantum ; (2) the hyperendemicity of canine leishmaniases in the Thies region; and (3) a potential risk for human health.…”

Section: Introductionmentioning

confidence: 99%

A Case of Visceral Leishmaniasis in a 4-Year-Old Child Living in Nonendemic Area Located in Suburbs of Dakar, Senegal

Ndiaye,

Cissé,

Djigal

et al. 2023

Case Reports in Infectious Diseases

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Visceral leishmaniasis (VL) is an infectious disease caused by protozoa of the genus Leishmania. Sporadic cases are observed in nonendemic areas and often associated with limited foci; therefore, the disease is easily overlooked. In addition, other diseases have similar clinical symptoms, which make it difficult for clinicians to make an accurate diagnosis and to provide effective treatment. We identified visceral leishmaniasis in a 4-year-old child in Pikine, Senegal. The patient was admitted to the Pikine National Teaching Hospital for haemorrhagic, tumoral, and infectious syndromes. At admission, the patient presented with epistaxis and gingivorrhagia, a severe anaemic syndrome poorly tolerated, a systemic inflammatory response syndrome with fever at 39.5°C, a tumoral syndrome with 11 cm of hepatomegaly and 12 cm of type IV splenomegaly, and noninflammatory macropoly adenopathies. A spinal cord puncture was performed, and direct microscopy examination of the sample after GIEMSA staining revealed amastigote forms of Leishmania. The PCR amplification of extracted DNA from the bone marrow aspiration using specific primers for VL (forward and reverse) confirmed that VL was responsible for the infection. A treatment with meglumine antimoniate (Glucantime) was given and it gave a successful outcome with remission of clinical symptoms and favourable evolution with 3 months hindsight. Conclusion. This visceral leishmaniasis case diagnosis in Senegal has shown that, apart from haematological malignancies, this disease must be considered in combination with a tumor syndrome, haemorrhagic syndrome, and infectious syndrome.

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Leishmaniose cutanée à Leishmania infantum : un grand polymorphisme clinique mais un arsenal thérapeutique limité

Caumes

2016

Annales de Dermatologie et de Vénéréologie

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Leishmaniose cutanée à Leishmania infantum associée à une infection par le VIH

Cited by 5 publications

References 8 publications

Visceral Leishmaniasis in West Africa: Clinical Characteristics, Vectors, and Reservoirs

Visceral Leishmaniasis in West Africa: Clinical Characteristics, Vectors, and Reservoirs

A Case of Visceral Leishmaniasis in a 4-Year-Old Child Living in Nonendemic Area Located in Suburbs of Dakar, Senegal

Leishmaniose cutanée à Leishmania infantum : un grand polymorphisme clinique mais un arsenal thérapeutique limité

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