Leishmanicidal, cytotoxic, antimicrobial and enzymatic activities of Diaporthe species, a mangrove-isolated endophytic fungus

Moreira, Carla Cristina; Luna, Genoveva Lourdes Flores; Soriano, Bianca; Cavicchioli, Rafael; Bogas, Andréa Cristina; Sousa, Cristina Paiva de; Aníbal, Fernanda de Freitas; Lacava, Paulo Teixeira

doi:10.5897/ajmr2020.9397

Cited by 7 publications

(4 citation statements)

References 40 publications

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“…Recently, Rajini et al (2020) established cellulase production as one of the traits of endophytes Trichoderma asperellum, Epicoccum nigrum and Alternaria longipes involved in Sorghum bicolor colonization and in vitro inhibition growth of Fusarium thapsinum, Epicoccum sorghinum, Alternaria alternata and Curvularia lunata by hydrolysis of the cell wall. Moreira et al (2020) studied the endophyte Diaphorte sp. FS-94(4) and attributed the production of celullase in this strain as one of the traits related to in vitro inhibition growth of phytopathogens Colletotrichum sp., Fusarium oxysporum, Phythophthora sojae and Rhizopus microspores.…”

Section: Endophytic Fungi As a Source Of Natural Bioactive Metabolitesmentioning

confidence: 99%

“…Avicennia nitida (Sebastianes et al, 2013) showed in vitro activity against the human pathogens Escherichia coli (ATCC 25922), S. enteritidis (ATCC 19196), S. aureus (ATCC 6538), and Candida albicans (ATCC 10231) (Moreira et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Caicedo et al (2019) used a 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay and verified the high antioxidant activity of exopolysaccharides present in crude extracts of the endophytic fungus Fusarium oxysporum isolated from the tropical medicinal plant Otoba gracilipes. Moreira et al (2020) showed the antiparasitic activity of crude extracts obtained from the endophyte Diaphorte sp. 94(4) against the promastigote form of Leishmania infantum chagasi (MHOM/BR/1972/LD).…”

Section: Introductionmentioning

confidence: 99%

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Endophytic fungi: an overview on biotechnological and agronomic potential

et al. 2024

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Endophytic fungi colonize the inter- and/or intracellular regions of healthy plant tissues and have a close symbiotic relationship with their hosts. These microorganisms produce antibiotics, enzymes, and other bioactive compounds that enable them to survive in competitive habitats with other microorganisms. In addition, secondary metabolites confer protection to their host plant against other bacterial and fungal pathogens and/or can promote plant growth. Endophytic fungi are viewed as a promising source of bioactive natural products, which can be optimized through changes in growing conditions. The exploration of novel bioactive molecules produced by these microorganisms has been attracting attention from researchers. The chemical and functional diversity of natural products from endophytic fungi exhibits a broad spectrum of applications in medicine, agriculture, industry and the environment. Fungal endophytes can also enhance the photoprotective effects and photochemical efficiency in the host plants. Modern omic approaches have facilitated research investigating symbiotic plant-endophytic fungi interactions. Therefore, research on endophytic fungi can help discovery novel biomolecules for various biotechnological applications and develop a sustainable agriculture.

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Section: Endophytic Fungi As a Source Of Natural Bioactive Metabolitesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Endophytic fungi: an overview on biotechnological and agronomic potential

et al. 2024

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“…By definition, endophytic microorganisms are bacteria and fungi that live symbiotically associated with healthy plant tissues without causing any apparent damage to their host [14]. Endophytes are a source of several secondary metabolites with, for example, antimicrobial [15], antitumor [16], enzymatic [17], anti-COVID [18], and antibiofilm activities. The main antibiofilm compounds currently sought are those capable of i) preventing or inhibiting microbial adhesion to avoid biofilm formation, ii) dispersing the already formed biofilm, and iii) interfering with intra/extracellular communication for biofilm formation (anti-QS) [19].…”

Section: Introductionmentioning

confidence: 99%

Development of Antibiofilm Substances by Endophytic Microorganisms with an Emphasis on Medicine

Rodrigues¹,

Assis²,

Foggi³

et al. 2022

Focus on Bacterial Biofilms

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The growing antimicrobial resistance and persistence of pathogenic microorganisms in infections–particularly in nosocomial infections–have become a major problem for public health worldwide. One of the main causes of these issues is the formation of biofilms, which are microbial communities associated with extracellular polymeric substances (EPS) that form a slimy extracellular matrix, causing the bacteria to become more tolerant to usual drugs in these structures. Thus, the search for new antibiofilm compounds is part of a strategy to deal with this problem. Endophytic microorganisms such as bacteria and fungi, mutualistically associated with plants, are sources of compounds with biological properties, including antimicrobials, and can be important allies in the synthesis of antibiofilm. These secondary metabolites can interfere with cell-to-cell communication and cell adhesion ability, promoting the dispersal of bacterial colonies and affecting biofilm. Since endophytes are cultivable in laboratory conditions, these microorganisms are environmentally friendly, as they do not contribute to pollution, are easy to handle and are produced on a large scale. Furthermore, metabolites from endophytes are of natural origin and may contribute to the reduced use of synthetic drugs. Considering these aspects, this chapter will focus on the characterization of endophytic microorganisms as potential active sources of antibiofilm and antimicrobial compounds with applications in medicine.

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