Leishmanicidal activity of the crude extract, fractions and major piperidine alkaloids from the flowers of Senna spectabilis

Melo, Gabriela Muniz de Albuquerque; Silva, Marcela Campelo Rodrigues; Guimarães, Thaís Pereira; Pinheiro, Kátia Mantovani; Matta, Carolina Barbosa Brito da; Queiroz, Aline Cavalcanti de; Pivatto, Marcos; Bolzani, Vanderlan da Silva; Alexandre-Moreira, Magna Suzana; Viegas, Cláudio

doi:10.1016/j.phymed.2013.09.024

Cited by 26 publications

(16 citation statements)

References 32 publications

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“…However, no antileishmanial studies being done on this compound thus far. On the other hand, a mixed compounds of (-)-spectaline and (-)-cassein from the flower of S. spectabilis has been reported to have antileishmanial properties (IC 50 = 24.9 ± 1.4 µg/mL) via extracellular promastigote assay by De Albuquerque Melo and colleagues [28]. To the best of our knowledge, this is the first report on the antileishmanial activity of (+)-spectaline via intracellular amastigotes assay model.…”

Section: Resultsmentioning

confidence: 72%

“…In antileishmanial area of study, a few alkaloids have been proven to be effective against extracellular promastigotes which have been extensively listed by Chan-Bacab and Pena Rodriguez [27]. In a more recent study [28], mixed compounds of major piperidine alkaloids from S. spectabilis flowers extract which consist of (-)-spectaline and (-)-casein have been claimed to be effective against promastigotes of L. major. Through intracellular amastigotes assay model, several pure alkaloids such as berberine [29], liriodenin [30], harmaline [27] and gabunine [31] have been proven for their antileishmanial activity.…”

Section: Resultsmentioning

confidence: 99%

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(+)-Spectaline, a Piperidine Alkaloid from Senna spectabilis DC. Effective in Reducing the In Vitro Infection of Leishmania major

Sain

Amanah

Zahari

et al. 2016

IJPPE

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Senna spectabilis is known to have antimicrobial, laxative, antiulcerogenic, analgesic, and anti-inflammatory properties in folk medicine. Piperidine alkaloids extracted from various parts of this plant have been shown to have anticonvulsant (iso-6-spectaline), antinociceptive [(-)-spectaline] and lipid peroxidation [(+)-3-O-feruloylcassine, (-)-spectaline and (-)-3-O-acetylspectaline] activities. In our study, the ethyl acetate extract from S. spectabilis exhibited antileishmanial activity via intracellular promastigote assay or leishmanicidal assay and was further fractionated by using bioassay-guided isolation approach. The antiprotozoal principle was isolated from the ethyl acetate portion through solvent fractionation and a few series of chromatographic processes. The isolated active compound 1 was identified as (+)-spectaline on the basis of its spectral analysis (MS, 1D & 2D NMR) with EC50 value of 0.063 ± 0.005 µM for antileishmanial activity and selectivity index of 3.76.

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Section: Resultsmentioning

confidence: 72%

Section: Resultsmentioning

confidence: 99%

(+)-Spectaline, a Piperidine Alkaloid from Senna spectabilis DC. Effective in Reducing the In Vitro Infection of Leishmania major

Sain

Amanah

Zahari

et al. 2016

IJPPE

View full text Add to dashboard Cite

show abstract

“…Piperidine alkaloids from Senna spectabilis establish an uncommon class of natural products with a few organic exercises [76]. In society prescription, this plant is shown for the treatment of obstruction, sleep deprivation, uneasiness, epilepsy, jungle fever, looseness of the bowels and cerebral pain [77]. S. spectabilis is an imperative wellspring of piperidine alkaloids with leishmanicidal movement [78,79].…”

Section: Pyrrole: Stachydrinementioning

confidence: 99%

Chemistry of Secondary Metabolites

Mohiuddin¹

2019

ACT

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Medicinal plants, are known to deliver a wide scope of Plant Secondary Metabolites (PSMs) connected as bug sprays, medications, colors and poisons in farming, prescription, industry and biofighting in addition to bio-fear mongering, separately. Be that as it may, creation of PSMs is for the most part in little amounts, so we have to discover novel approaches to increment both amount and nature of them. Luckily, biotechnology proposes a few choices through which secondary metabolism in plants can be built in imaginative approaches to: 1) over-produce the valuable metabolites, 2) down-produce the poisonous metabolites, 3) produce the new metabolites. Secondary metabolites are extensively characterized as natural products integrated by a life form that is not basic to help development and life. The plant kingdom fabricates more than 200,000 unmistakable chemical compounds, a large portion of which emerge from particular metabolism. While these compounds assume critical jobs in interspecies challenge and safeguard, many plant natural products have been abused for use as prescriptions, scents, flavors, supplements, repellants, and colorants. In spite of this immense chemical decent variety, numerous secondary metabolites are available at low focuses in plant a, taking out yield based assembling as methods for achieving these imperative products. The basic and stereo chemical unpredictability of particular metabolites frustrates most endeavors to get to these compounds utilizing chemical blend. Albeit local plants can be built in amass target pathway metabolites. This Update gives a concise outline of designing plant secondary metabolism in microbial frameworks. We quickly diagram biosynthetic pathways intervening arrangement of the real classes of natural products with an accentuation on high-esteem terpenoids, alkaloids, phenylpropanoids, and polyketides. We additionally feature basic topics, techniques, and provoke hidden endeavors to reproduce and build these pathways in microbial hosts. We center mostly around again biosynthetic methodologies in which plant specific metabolites are combined straightforwardly from sugar feed stocks instead of enhanced forerunners or intermediates.

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“…There are also several reports [46] of populations of S. spectabilis from Brazil, whose fruits and flowers have pharmacological effects (analgesic and anti-inflammatory) due to the presence of more than 20 piperine and piperidine alkaloid compounds. It has been also presented important compounds report in leishmanicidal activity [47] and the strongly inhibit cell proliferation of hepatocellular carcinoma cells in alkaloids derived from flowers (in vitro antiproliferative and cytotoxic potentials of alkaloid mixture); if they represent promise antitumor compounds against liver cancer and should be considered for further anticancer in vivo studies [48].…”

Section: Propagationmentioning

confidence: 99%

Novel Therapeutic Uses of Legume Crops in Southern South America

Fortunato¹,

Baluzzi²,

Diego³

et al. 2019

Legume Crops - Characterization and Breeding for Improved Food Security

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The Argentine flora comprises more than 10,000 species, and many of them have been recorded as having medicinal, antimicrobial, and nutraceutical uses in humans as well as veterinary uses. In this chapter, native species/populations from the north of Argentina have been identified, selected, and characterized using morphological, chemical, and molecular techniques. Bauhinia forficata subsp. pruinosa was found to have anti-inflammatory, antidiabetic, diuretic, and analgesic activity and Senna spectabilis var. spectabilis has been found to have antibacterial, antibiofilm, antifungal, and antioxidant properties. The characterization and conservation of the native germplasm will allow us to propose future protocols of adaptation and technological processes to improve the quality of life in the rural areas and sustainable growth. This process will be achieved through a future integral and rational use that contemplates the conservation of the wild populations and their habitat. Thus, new resources will be generated, and the native flora of the country will gain value, strengthening the regional and territorial development of the agricultural and agroindustrial system. In addition, the domestication practices oriented to an integral management of the crop without extraction of the biological resource from the natural habitat minimize the impact of ecosystem degradation by overexploitation associated with landscape fragmentation.

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Leishmanicidal activity of the crude extract, fractions and major piperidine alkaloids from the flowers of Senna spectabilis

Cited by 26 publications

References 32 publications

(+)-Spectaline, a Piperidine Alkaloid from <i>Senna spectabilis</i> DC. Effective in Reducing the <i>In Vitro</i> Infection of <i>Leishmania major</i>

(+)-Spectaline, a Piperidine Alkaloid from <i>Senna spectabilis</i> DC. Effective in Reducing the <i>In Vitro</i> Infection of <i>Leishmania major</i>

Chemistry of Secondary Metabolites

Novel Therapeutic Uses of Legume Crops in Southern South America

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