Leishmanicidal Activity and Structure-Activity Relationships of Essential Oil Constituents

Silva, Audrey R.S.T.; Scher, Ricardo; Santos, Flaviane Vieira; Ferreira, Sebastião Rodrigo; Cavalcanti, Sócrates C.H.; Corrêa, Cristiane Bani; Bueno, Lilian Lacerda; Alves, Ricardo José; Souza, Damião Pergentino De; Fujiwara, Ricardo Toshio; Dolabella, Silvio Santana

doi:10.3390/molecules22050815

Cited by 33 publications

(27 citation statements)

References 45 publications

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“…Ten chemical constituents of EOs, including nine monoterpenes and one phenylpropanoid, were investigated as antileishmanial agents against promastigote forms of L. amazonensis [187]. Among the monoterpenes evaluated, the positional isomers carvacrol ( 10 ) and thymol ( 1 ) that presented a phenolic moiety were the most active compounds, showing moderate antiparasitic activity, with IC 50 values of 25.4 and 26.8 μ g/mL, respectively.…”

Section: Introductionmentioning

confidence: 99%

Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses

Luna

Scotti

et al. 2019

Oxidative Medicine and Cellular Longevity

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The termneglected diseasesrefers to a group of infections caused by various classes of pathogens, including protozoa, viruses, bacteria, and helminths, most often affecting impoverished populations without adequate sanitation living in close contact with infectious vectors and domestic animals. The fact that these diseases were historically not considered priorities for pharmaceutical companies made the available treatments options obsolete, precarious, outdated, and in some cases nonexistent. The use of plants for medicinal, religious, and cosmetic purposes has a history dating back to the emergence of humanity. One of the principal fractions of chemical substances found in plants are essential oils (EOs). EOs consist of a mixture of volatile and hydrophobic secondary metabolites with marked odors, composed primarily of terpenes and phenylpropanoids. They have great commercial value and were widely used in traditional medicine, by phytotherapy practitioners, and in public health services for the treatment of several conditions, including neglected diseases. In addition to the recognized cytoprotective and antioxidative activities of many of these compounds, larvicidal, insecticidal, and antiparasitic activities have been associated with the induction of oxidative stress in parasites, increasing levels of nitric oxide in the infected host, reducing parasite resistance to reactive oxygen species, and increasing lipid peroxidation, ultimately leading to serious damage to cell membranes. The hydrophobicity of these compounds also allows them to cross the membranes of parasites as well as the blood-brain barrier, collaborating in combat at the second stage of several of these infections. Based on these considerations, the aim of this review was to present an update of the potential of EOs, their fractions, and their chemical constituents, against some neglected diseases, including American and African trypanosomiasis, leishmaniasis, and arboviruses, specially dengue.

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Section: Introductionmentioning

confidence: 99%

Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses

Luna

Scotti

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…The anti- Toxoplasma activity of citronella oil is probably owed to its chemical constituents. Monoterpenes have been reported to exert antileishmanial activity [ 51 , 86 ]. However, further studies are needed to explore the mechanism of action of citronella oil against T. gondii.…”

Section: Discussionmentioning

confidence: 99%

Effect of some plant extracts from Egyptian herbal plants against <i>Toxoplasma gondii</i> tachyzoites <i>in vitro</i>

2021

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Nowadays, herbal extracts are considered to be a potential source for developing new drugs that will overcome resistance to conventional chemotherapeutic agents. This study was aimed to explore the efficacy of several Egyptian plant extracts against Toxoplasma gondii infection in vitro for future development of a new, safe, and effective compound for T. gondii. Methanol extracts from Matricaria chamomilla (German chamomile), Laurus nobilis, Citrullus colocynthis, Cinnamum camphora, Boswellia scara, and Melissa officionalis plants and oil extracts (either essential or fixed oils) of some plants such as: lemon grass (Cymbopogon citratus), marjoram (Origanum majorana), watercress (Nasturtium officionale), wheat germ (Triticum aestivum), sesame (Sesamum indicum), rosemary (Salvia rosmarinus), citronella (Cymbopogon nardus), clove (Syzygum aromaticum), jojoba (Simmondsia chinesis), and basil (Ocimum basilicum) were investigated for their anti-Toxoplasma activities. The methanol extracts from C. colocynthis and L. nobilis and the oil extracts from lemon grass and marjoram were active against T. gondii with half maximal inhibitory concentrations (IC 50) of 22.86 µg/ml, 31.35 µg/ml, 4.6 µg/ml, and 26.24 µg/ml, respectively. Their selectivity index (SI) values were < 10. Interestingly, the methanol extract from M. chamomilla and oil from citronella had the lowest IC 50 values for T. gondii (3.56 µg/ml and 2.54 µg/ml, respectively) and the highest SI values (130.33 and 15.02, respectively). In conclusion, methanol extract from M. chamomilla and oil from citronella might be potential sources of novel therapies for treating toxoplasmosis.

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“…Although the clinically relevant form of the parasite is the amastigote form, which shows metabolic differences from the extracellular forms, promastigotes can be used for fast screenings of potential compounds (Tempone et al 2005;Martín-Montes et al 2017;Silva et al 2017). Thus, in this study, we evaluated the effect of dihydroquinoline lactone derivatives against promastigote forms of L. (L.) amazonesis in vitro.…”

Section: Antileishmanicidal Activitiesmentioning

confidence: 99%

In vitro leishmanicidal activity of lactone 1,4-dihydroquinoline derivatives against Leishmania (Leishmania) amazonensis

et al. 2018

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A series of lactone 1,4-dihydroquinoline derivatives 4 (4 and 4aa-4cm) was screened for in vitro antileishmanial activity against the promastigote form of Leishmania (Leishmania) amazonensis. Screening results indicate that all of the synthesized compounds significantly reduced the growth of promastigote forms of promastigotes of L. (L.) amazonensis. The cytotoxicity of the most active compounds was also measured on peritoneal macrophage cells. Compounds 4ah and 4bn showed better activities than other derivatives with IC 50 values of 6.22 and 9.05 μM, respectively, with selectivity index 22 and 15 times less toxicity to macrophages cells than to parasites, respectively. The experimental data propose that the compounds may be further investigated against amastigote forms and may contribute to the search of new candidates drugs for treatment of cutaneous leishmaniasis.

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Leishmanicidal Activity and Structure-Activity Relationships of Essential Oil Constituents

Cited by 33 publications

References 45 publications

Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses

Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses

Effect of some plant extracts from Egyptian herbal plants against <i>Toxoplasma gondii</i> tachyzoites <i>in vitro</i>

In vitro leishmanicidal activity of lactone 1,4-dihydroquinoline derivatives against Leishmania (Leishmania) amazonensis

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