Leishmaniasis and Kaposi's Sarcoma in an HIV-Infected Patient

Abajo, P; Buezo, G. F.; Fraga, Javier; Sanz, Jesús; Daudén, E.

doi:10.1097/00000372-199702000-00020

Cited by 14 publications

(8 citation statements)

References 4 publications

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“…In other cases the presence of Leishmania was coincidental. This coincidence has been observed previously with Kaposi's sarcoma, [16][17][18][19][20][21][22] herpesvirus infection 23,24 and bacillary angiomatosis. 14 Leishmania organisms may occur accidentally in healthy skin or in cutaneous lesions such as those of Kaposi's sarcoma or bacillary angiomatosis as a result of their dissemination during a VL in the presence of a deeply impaired immunity or HIV infection.…”

Section: Discussionsupporting

confidence: 84%

Visceral leishmaniasis with cutaneous lesions in a patient infected with human immunodeficiency virus

Ara¹,

Maillo²,

Peón

et al. 1998

Br J Dermatol

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We report a case of visceral leishmaniasis (VL) with cutaneous lesions in a patient infected with human immunodeficiency virus (HIV). The cutaneous lesions consisted of erythematous papules on the legs. Biopsy of one lesion showed abundant Leishmania amastigotes within epithelial cells of an eccrine sweat gland in the dermis. Leishmania organisms were also found in a blood smear. Rapid and complete clearance of the cutaneous lesions was achieved after antimony therapy. Cutaneous lesions in VL are being reported increasingly frequently in patients with HIV infection and their significance remains in discussion.

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Section: Discussionsupporting

confidence: 84%

Visceral leishmaniasis with cutaneous lesions in a patient infected with human immunodeficiency virus

Ara¹,

Maillo²,

Peón

et al. 1998

Br J Dermatol

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“…1,5,6,[11][12][13] The diagnosis usually is made in a cutaneous biopsy specimen or by finding Leishmania amastigotes in a bone marrow smear or biopsy specimen or, less frequently, in a liver biopsy specimen. [15][16][17][18] However, when the pathologist has difficulty with the diagnosis of leishmaniasis, immunolabeling with specific anti-Leishmania antibodies can be useful for confirming the diagnosis or for eliminating other potential diagnoses.…”

Section: Discussionmentioning

confidence: 99%

“…42,43 Finally, mucocutaneous association of Leishmania and Kaposi sarcoma have been reported in AIDS. 6,11,13,44 Finally, immunolabeling with specific anti-Leishmania antibodies can be useful to eliminate other infectious diseases in tissue sections stained with HES. Thus, Leishmania species must be differentiated from a variety of other microorganisms, including T cruzi, H capsulatum, P marneffei, and T gondii.…”

Section: Discussionmentioning

confidence: 99%

“…Sixteen cases of visceral leishmaniasis in patients with AIDS were reported previously. 6,[11][12][13] The clinical records, biopsy specimens, and surgical pathology specimens were reviewed for all cases; autopsy protocols were reviewed for 22 cases. All microscopic slides were reviewed, including sections stained with H&E-safran (HES) and Giemsa.…”

Section: Methodsmentioning

confidence: 99%

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Immunostaining of Visceral Leishmaniasis Caused byLeishmania infantumUsing Monoclonal Antibody (19–11) to theLeishmaniaHomologue of Receptors for Activated C-Kinase

Hofman¹,

Brousset

Mougneau

et al. 2003

Am J Clin Pathol

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It sometimes is difficult to diagnose leishmaniasis in tissue sections or in smears, particularly in unusual sites or if few parasites are present in the lesion. Leishmania species must be differentiated morphologically from a variety of other microorganisms, including Toxoplasma gondii, Histoplasma capsulatum, Trypanosoma cruzi, and Penicillium marneffei. We tested the value of monoclonal antibody p19-11 raised against the Leishmania homologue of receptors for activated C-kinase (LACK) as an immunohistochemical marker for amastigotes of Leishmania infantum. We evaluated a total of 117 paraffin-embedded lesions due to L infantum (92 cases), T gondii (15 cases), H capsulatum (5 cases), T cruzi (3 cases), and P marneffei (2 cases). Amastigotes of Leishmania species were detected in 92 (100%) of the leishmaniasis lesions. There were no false-positive LACK immunoreactions in any of the toxoplasmosis, histoplasmosis, trypanosomiasis, or penicilliosis specimens (0/25). We found the anti-LACK antibody p19-11 to be a highly specific and sensitive paraffin-reactive immunohistochemical marker for the confirmation or identification of Leishmania species in tissue sections.

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“…O diagnóstico de leishmaniose não pode ser afastado somente com uma sorologia negativa (Alvar et al, 1989;Gradoni et al, 1993;WHO, 1997;López-Vélez et al, 1998). Os tipos de testes mais estudados na co-infecção são pesquisas de anticorpos anti-Leishmania por teste imunofluorescência indireta ou teste imunoenzimático de "Enzyme-Linked Immunosorbent Assay" (ELISA), aglutinação direta (DAT) e teste rápido por fita (comercial e da OMS -"dipsticks"), estes com utilização de antígenos totais e/ou antígeno rK39 (Deniau et al, 2003 (Abajo et al, 1997, Romeu et al, 1991, herpes zoster (Del Giudice, 1996) e dermatofibromas (Colebunders et al, 1999), ou ainda, em pele sadia de pacientes com LV (Yebra et al, 1988;Pierrin et al, 1995 …”

Section: Leishmaniose Visceralunclassified

Co-infecção HIV/Leishmania: manifestações clínicas em uma série de casos

Vergara¹

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Descritores: 1.LEISHMANIOSE VISCERAL/parasitologia 2. LEISHMANIOSE CUTÂNEA/parasitologia 3. LEISHMANIOSE MUCO-CUTÂNEA/parasitologia 4.HIV 5.SÍNDROME DE IMUNODEFICIÊNCIA ADQUIRIDA/complicações 6.LEISHMANIA/parasitologia 7.SINAIS E SINTOMAS 8.LINFÓCITOS T CD4-POSITIVOS USP/FM/SBD-057/05iii Dedicatória Ao Dr. Hernán Vergara Delgado (in memorian), meu avó, padrinho, mestre e exemplo de vida, por ter deixado a única herança que não morre:conhecer a Deus.A minha mãe, pelo seu imensurável amor e pela sabedoria com que levou seus filhos pelo caminho da vida.A oRenato, pelo seu amor e companhia nestes anos, e por seu exemplo de compromisso com a medicina.A todas as pessoas que com sua amizade, carinho, estímulo, acolhimento e paciência me acompanharam nestes anos longe de casa.iv AGRADECIMENTOS À Profa. Dra. Hiro Goto, pelos ensinamentos, incentivo, inesgotável paciência, compreensão e segura companhia, minha admiração e gratidão por ter orientado este trabalho.Ao Dr. Ângelo Lauletta Lindoso, por ter sido fundamental em levar meu interesse por bom caminho, sem seu conselho, ajuda, impulso e amizade não existiria este trabalho. LISTA DE ABREVIATURAS E SIGLAS AIDS

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Leishmaniasis and Kaposi's Sarcoma in an HIV-Infected Patient

Cited by 14 publications

References 4 publications

Visceral leishmaniasis with cutaneous lesions in a patient infected with human immunodeficiency virus

Visceral leishmaniasis with cutaneous lesions in a patient infected with human immunodeficiency virus

Immunostaining of Visceral Leishmaniasis Caused byLeishmania infantumUsing Monoclonal Antibody (19–11) to theLeishmaniaHomologue of Receptors for Activated C-Kinase

Co-infecção HIV/Leishmania: manifestações clínicas em uma série de casos

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