Leishmanial infection: analysis of its first steps. A review

Abstract

The first steps in leishmaniasis are critical in determining the evolution of the disease. Major

Perfil histopatológico e imuno-histoquímico da leishmaniose tegumentar americana com ênfase nos dendrócitos dérmicos FXIIIa+

“…9 In view of the relevant aspects of the DDFXIIIa+, still under study according to the literature, we chose to perform this research using this marker, comparing it in cutaneous leishmaniasis and in normal control skin, in order to observe the behavior of this group of dendritic cells. Other cells also cluster to granulomas, such as lymphocytes, plasmocytes, eosinophils and fibroblasts.…”

Use of Cavia porcellus (guinea pigs) as an experimental model for Leishmania (Viannia) braziliensis

“…Thirty-two experimental animals were injected in the hind foot with 3x10 5 promastigote forms of L(V)b, strain MHOM/BR/94/M15176, identified by monoclonal antibodies and polymerase chain reaction (PCR). The animals were followed for eight weeks.…”

“…The animals were followed for eight weeks. Weekly, two individuals were sacrificed and fragments of their foot, liver, spleen, regional ganglia, nose, and bone marrow were taken for parasitological tests (4,5,14): culture, smears, inoculation in hamsters, polymerase chain reaction (2), and histopathological exam (3, 9).…”

Diagnosing Neglected Tropical Diseases in HIV Coinfection

“…51 The prevalence of Chagas/HIV coinfection around the world is difficult to establish. 52 Almeida et al 53 published a study involving 716 patients with HIV treated in a University Hospital in Brazil. Of these, nine individuals (1.3%) tested positive on serologic tests and were diagnosed with Chagas/HIV coinfection.…”

“…76 The parasite is transmitted by the bite of the sandfly Lutzomyia in the New World and by Phlebotomus in the Old World, by inoculating the promastigote form of the parasite into the skin. 52 Species from the subgenus Leishmania can cause tegumentary or visceral lesions. L. donovani is the causal agent of VL in the Indian subcontinent, L. infantum in Europe and in some parts of Africa, and L. infantum chagasi in Latin America.…”