Leishmania tropica: intraspecific polymorphisms in lipophosphoglycan correlate with transmission by different Phlebotomus species

Experimental transmission of Leishmania tropica to hyraxes (Procavia capensis) by the bite of Phlebotomus arabicus

“…However, zoonotic strains of L. tropica from Israel produce only small or no lesions in BALB/c mice (Svobodová, unpublished). These strains also differ in the structure of their most abundant promastigote surface molecule, lipophosphoglycan (LPG) [13], which is probably responsible for their switch to another sand fly vector. Sand flies from the subgenus Adlerius are permissive vectors, which support the development of several Leishmania species [14], while P. sergenti is permissive only for L. tropica [15].…”

Distinct Transmission Cycles ofLeishmania tropicain 2 Adjacent Foci, Northern Israel

“…LPG of L. tropica from the northern focus is characterized by abundant terminal β-galactose residues on side chains. Conversely, β-galactose residues on LPG side chains of other L. tropica isolates are mostly capped with glucose ( 27 ). Differences in sugar moieties may have a role in infection of P. sergenti (Figure 4).…”

Intraspecies Variation in Trypanosoma cruzi GPI-Mucins: Biological Activities and Differential Expression of α-Galactosyl Residues

“…Samples were run in polyacrylamide gels and visualized by an ultraviolet (UV) imager. 34 Unweighted pair group method analysis. All strains/ populations used in this work were previously characterized as T. cruzi I, II, or VI (Table 1).…”