Leishmania tropica Infections in Travellers

The management of cutaneous leishmaniasis from Belize

“…Surgical treatment may be suitable for simple cutaneous disease provided that L. braziliensis complex is excluded. In uncomplicated cases from the Old World, no treatment may be appropriate 14 …”

“…In uncomplicated cases from the Old World, no treatment may be appropriate. 14 Intravenous sodium stibogluconate, 20 mg/kg per day for 20 days, is a widely recognized regime. It is a highly effective treatment of American cutaneous leishmaniasis, achieving cure in 88±100% of patients.…”

Histopathological features in leprosy, post-kala-azar dermal leishmaniasis, and cutaneous leishmaniasis

“…For instance, L. tropica minor in the Middle East usually results in a single dry ulcer, whereas L. tropica major results in multiple weeping ulcers. [28,29] A recent report [30] describes four histopathological patterns ranging from a mixed inflammatory pattern composed of lymphocytes, plasma cells and macrophages with many LD bodies to a granulomatous pattern with few or no LD bodies. Another study from Himachal Pradesh, in which the lesions were caused by L. donovani, showed non-caseating epithelioid granuloma in 77% of the cases and LD bodies were demonstrable in 37% of tissue smears.…”

Cutaneous leishmaniasis: cryosurgery using carbon dioxide slush in a resource‐poor country

“…An early study demonstrated promising results, indicating complete eradication of parasites in 4–5 weeks with good healing. However, cure rates may be as low as 30% with cryotherapy 20 . Seventeen Greek patients with CL were treated with cryosurgery using liquid nitrogen as the cryogen, utilized as two cycles of 10–30‐second freezing time and repeated at three‐week intervals 21 .…”