Leishmania mexicana amazonensis isolated from a patient with fatal mucosal leishmaniasis

Sampaio, Raimunda Nonata Ribeiro; Marsden, Philip D.; Cuentas, Elmer Alejandro Llanos; Cuba, César Augusto Cuba; Grimaldi, Gabriel

doi:10.1590/s0037-86821985000400015

Cited by 15 publications

(4 citation statements)

References 4 publications

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“…2,3 Leishmania (L.) amazonensis has also been implicated in non-cutaneous forms of the disease such as mucosal, visceral, and post-kala-azar dermal leishmaniasis. 4,5 Visceral leishmaniasis can also be caused by L. (L.) amazonensis in patients with associated infections with human immunodeficiency virus. 6 It has been shown that BALB/c mice are highly susceptible to L. (L.) amazonensis, and show a progressive infection that may disseminate to lymph nodes, spleen, and liver, and promote metastasis in almost all extremities of the animal body.…”

Section: Introductionmentioning

confidence: 99%

Central Nervous System Involvement in Experimental Infection With Leishmania (Leishmania) Amazonensis

Abreu-Silva

Calabrese²,

Tedesco³

et al. 2003

The American Journal of Tropical Medicine and Hygiene

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Abstract. We describe the pathologic alterations of the central nervous system (CNS) observed in experimental tegumentary leishmaniasis in BALB/c and Swiss mice. The mice were subcutaneously infected with 10 4 amastigotes of Leishmania (Leishmania) amazonensis. Animals were killed and brains were removed for histologic and immunocytochemical studies. Histologic examination showed that 66.6% of infected mice had a discrete hyperemia and inflammatory infiltrate in the meninges, composed of mononuclear cells and neutrophils with no detectable parasites. However, parasitized macrophages were detected in the cerebral parenchyma, as well as mast cells, lymphocytes, and polymorphonuclear cells. Necrosis in the cerebral parenchyma was also observed. Confocal fluorescence microscopy showed that CD8 + T lymphocytes are the major component of the inflammatory infiltrate in the CNS. In addition to these cells, CD4 + , CD11b, and dendritic cells are present, in small numbers, in the inflammatory processes of the CNS. Thus, L. amazonensis is able to cross the blood-brain barrier and cause significant pathologic changes in the CNS.

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Section: Introductionmentioning

confidence: 99%

Central Nervous System Involvement in Experimental Infection With Leishmania (Leishmania) Amazonensis

Abreu-Silva

Calabrese²,

Tedesco³

et al. 2003

The American Journal of Tropical Medicine and Hygiene

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“…It is also important to note that there are some reported cases of primary or secondary CL lesions after localized trauma, and these lesions can appear months later 4,5 . In our experience of more than 2,000 cases of ATL, we have observed 3 cases triggered by trauma: one after a bicycle trauma on the ankle cause by L. (L.) amazonensis 9 ; one after a snake bite; and one after a laser hair removal procedure. In addition, previous studies in murine models infected with Leishmania support the possibility of metastatic cutaneous lesions at sites of trauma 5 .…”

Section: Discussionmentioning

confidence: 98%

American cutaneous leishmaniasis triggered by electrocoagulation

Martins

Santos

Lima

et al. 2018

Rev. Soc. Bras. Med. Trop.

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Cutaneous leishmaniasis is usually transmitted by infected phlebotomine sand fly bites that initiate local cutaneous lesions. Few reports in the literature describe other modes of transmission. We report a case of a previously healthy 59-year-old woman who underwent electrocoagulation to remove seborrheic keratosis confirmed by dermatoscopy. Three months later, a skin fragment tested positive for Leishmania culture; the parasite was identified as L. (V.) braziliensis. Trauma may generate inflammatory cascades that favor Leishmania growth and lesion formation in previously infected patients. American cutaneous leishmaniasis is a dynamic disease with unclear pathophysiology because of continually changing environments, demographics, and human behaviors.

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“…O curso clínico da leishmaniose cutânea é complexo devido à variabilidade do período de incubação, da infecção subclínica, cura espontânea, propagação metastática, reativação, reinfecções e lesões crônicas (WEIGLE & SARAVIA, 1996). A L. amazonensis foi recentemente isolada de pacientes com diversas formas de leishmanioses incluindo cutânea, mucosa, difusa e visceral (BARRAL et al, 1991;BARRAL et al, 1986;SAMPAIO et al, 1985).…”

Section: A Leishmanioseunclassified

Avaliação dos efeitos de microambiente hipoxico em celulas dendriticas humanas infectadas com Leishmania amazonensis

Bosetto¹,

Giorgio²

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Paulo, com apoio fincanceiro do CNPq e da FAPESP (Processo # 03/12679-6). v Dedico este trabalho aos meus pais e meus heróis Lourdes e Vanderlei, sem os quais eu não seria o que sou e a quem devo mais esta etapa de minha vida. vi Agradeço primeiramente a Deus, pelo dom da vida. Ao meu querido Engº Civil Nailton Bueno Mota, por construir em minha vida um mundo de felicidade, minha eterna gratidão pelo amor, carinho e compreensão nesta caminhada a dois. Aos meus queridos Juliana e Júnior pelo carinho, apoio e incentivos sempre presentes em mais esta jornada. vii AGRADECIMENTOS À minha orientadora, Profa. Dra. Selma Giorgio, pela inestimável orientação que possibilitou meu crescimento científico e, sobretudo pela paciência profissional e pessoal. A todos os meus familiares: avós, tios e primos pelo carinho e incentivo constantes. Aos meus grandes amigos do Laboratório de Leishmaniose Adriana, Diana, Marcelle e Wagner pelo apoio, carinho e amizade em todos os momentos profissionais e pessoais, alegres ou difíceis. Aos demais colegas do Laboratório de Leishmaniose pela amizade e apoio técnico. Aos professores, funcionários e demais colegas do Departamento de Parasitologia pela amizade e apoio técnico. Às amigas Jacy e Paula, do Departamento de Imunologia, pela amizade, carinho e colaboração constantes. Aos Drs Dimas T. Covas e Patrícia Palma, do Hemocentro do Hospital das Clínicas da USP/Ribeirão Preto, pela realização das análises de citometria de fluxo. À Profa Dra. Clara Barbieri da Unifesp/EPM de São Paulo, pela gentil colaboração com soros de paciente com leishmaniose e com sugestões oferecidas ao longo deste trabalho. Aos funcionários do setor de coleta de sangue do Hospital das Clínicas da UNICAMP, pelo carinho e atenção dispensados em meu aprimoramento na coleta de sangue. Aos professores, funcionários e colegas dos Departamentos de Imunologia, Microbiologia e Bioquímica, por toda colaboração ao longo deste trabalho.

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Leishmania mexicana amazonensis isolated from a patient with fatal mucosal leishmaniasis

Cited by 15 publications

References 4 publications

Central Nervous System Involvement in Experimental Infection With Leishmania (Leishmania) Amazonensis

Central Nervous System Involvement in Experimental Infection With Leishmania (Leishmania) Amazonensis

American cutaneous leishmaniasis triggered by electrocoagulation

Avaliação dos efeitos de microambiente hipoxico em celulas dendriticas humanas infectadas com Leishmania amazonensis

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