2001
DOI: 10.1016/s0304-4017(00)00446-5
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Leishmania infantum-specific IgG, IgG1 and IgG2 antibody responses in healthy and ill dogs from endemic areas

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Cited by 129 publications
(117 citation statements)
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“…Earlier studies to determine if specific IgG subclass levels in L. infantum-infected dogs are associated with the clinical outcome and hence with resistance or susceptibility to the disease, produced conflicting results [6,14,24,38]. However, these studies used commercial polyclonal anti-sera to canine IgG1 and IgG2, while we used the same monoclonal antibody panel (IgG1, IgG2, IgG3 and IgG4) previously employed by Quinnell et al [31,32].…”
Section: Discussionmentioning
confidence: 99%
“…Earlier studies to determine if specific IgG subclass levels in L. infantum-infected dogs are associated with the clinical outcome and hence with resistance or susceptibility to the disease, produced conflicting results [6,14,24,38]. However, these studies used commercial polyclonal anti-sera to canine IgG1 and IgG2, while we used the same monoclonal antibody panel (IgG1, IgG2, IgG3 and IgG4) previously employed by Quinnell et al [31,32].…”
Section: Discussionmentioning
confidence: 99%
“…Regarding concentrations of antibodies against rTRYP, although the decrease occurred one month after treatment was started, this decrease was observed in both groups of dogs. Consequently, ELISAs for CTLA 8,22 and rTRYP could not predict long-term clinical success of therapy.…”
Section: Discussionmentioning
confidence: 99%
“…8,15,21,22 This reduction is thought to be related to attenuated antigenic stimulation resulting from the decrease in parasite load. Our results might indicate that antigens such as rKMPII or rTRYP could be more sensitive than CTLA in detecting early reduction of Leishmania load in treated dogs, although the presence of seropositive dogs for these recombinant proteins at the end of the study could indicate persistence of subclinical infection.…”
Section: Discussionmentioning
confidence: 99%
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