Abstract:Two lots of 20 young male guinea pigs were inoculated subcutaneously in the tarsi with 10(4) amastigotes of Leishmania braziliensis braziliensis or L. b. guyanensis to study the susceptibility of this Neotropical hystricomorph rodent the autochthonous parasites. Almost 50% of the animals showed lesions in the inoculation site and had parasitizations that were infective to hamsters, as shown by inoculating homogenates of the dermal lesion, of the spleen, of the liver, and of the nasal mucosa into hamsters at 20… Show more
“…No cellular infiltration was observed in the histopathological exam. (15). Despite the results shown by this author, the search for mucous metastasis was negative using various laboratory methods, including PCR.…”
Section: Resultsmentioning
confidence: 73%
“…New drugs have been discovered to act against leishmaniasis, and laboratory animals are fundamental to study the efficacy of these drugs. showed promising results (11,15).…”
Laboratory animals are fundamental to study immunological aspects and the efficacy of new drugs to treat leishmaniasis. However, we do not have practical and good animal models to study leishmaniasis caused by Leishmania
“…No cellular infiltration was observed in the histopathological exam. (15). Despite the results shown by this author, the search for mucous metastasis was negative using various laboratory methods, including PCR.…”
Section: Resultsmentioning
confidence: 73%
“…New drugs have been discovered to act against leishmaniasis, and laboratory animals are fundamental to study the efficacy of these drugs. showed promising results (11,15).…”
Laboratory animals are fundamental to study immunological aspects and the efficacy of new drugs to treat leishmaniasis. However, we do not have practical and good animal models to study leishmaniasis caused by Leishmania
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