Léiomyosarcome de l’estomac : quelle prise en charge ?

Elkaoui, Hakim; Bourazza, Ahmed; Baba, H.; Rouibaa, Fedoua; Ali, Abdelmounaim Ait; Zentar, Aziz; Sair, Khalid

doi:10.1007/s10190-015-0523-4

Cited by 1 publication

(4 citation statements)

References 11 publications

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“…Imaging: X-ray, Computed Tomography Scan, Magnetic Resonance Imaging, and Positron Emission Tomography X-ray can show elevated lesions/filing defects with smooth margins 18 or may appear normal. 19 Abdominal computed tomography scans (Fig. 1) may reveal a mass 20,21 or thickening of the gastric wall, 22 with soft tissue density 21,23 or hyperdensity.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…The majority of biopsy results can confirm leiomyosarcoma, whereas other cases indicated no abnormality. 16,19,23,29 Uncommon findings include hyperplastic polyp, 30 leiomyoma, 31 smooth muscle/spindle cell tumor, 9,15,32 sarcoma with muscular differentiation, 13 and dysplasia. 22 Fine needle aspiration/biopsy from some cases 4,10,16 revealed bundles of well-differentiated spindle cells with blunt-ended nuclei and eosinophilic cytoplasm, devoid of mitotic figures, typically indicate spindle cell neoplasia with myogenic differentiation.…”

Section: Biopsy and Fine Needle Aspiration/biopsymentioning

confidence: 99%

“…X-ray can show elevated lesions/filing defects with smooth margins 18 or may appear normal 19 . Abdominal computed tomography scans (Fig.…”

Section: Epidemiology and Etiologymentioning

confidence: 99%

“…The majority of biopsy results can confirm leiomyosarcoma, whereas other cases indicated no abnormality 16,19,23,29 . Uncommon findings include hyperplastic polyp, 30 leiomyoma, 31 smooth muscle/spindle cell tumor, 9,15,32 sarcoma with muscular differentiation, 13 and dysplasia 22 …”

Section: Epidemiology and Etiologymentioning

confidence: 99%

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Gastric Leiomyosarcoma in Post–Gastrointestinal Stromal Tumor Era: Revisit

Wang,

Leng

2024

Advances in Anatomic Pathology

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Primary gastric leiomyosarcoma is an exceptionally rare disease. This review covers 41 post-gastrointestinal stromal tumor (GIST) era gastric leiomyosarcoma cases that are supported by immunohistochemistry markers. Other spindle cell lesions are also excluded through histological and immunohistochemistry evaluations. The patients range from 3 to 82 years old, with an average age of 54.6 years. The male-to-female ratio is 1.4:1, from diverse geographic areas. Patients may experience abdominal symptoms, and tumor sizes vary between 1 cm and 22 cm. Morphologically, tumors originate from the muscularis propria or the muscularis mucosae, well-circumscribed with spindle cells arranged in fascicule. Tumoral cells exhibit positivity for smooth muscle markers while being negative for GIST markers and others. The mitotic index ranges from 2 to 500/50 high power field. Ki-67 index varies from 15% to 70%. Management typically involves gastrectomy and other appropriate treatments, with tumor recurrence being uncommon. 56% of patients are alive, with 5 patients dying from this disease. Statistical analyses conducted on post-GIST era cases reveal that a mitotic index of ≥100/50 high power field, tumor recurrence, metastasis, or positive lymph nodes significantly correlate with prognosis.

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