Leiomyosarcomas affecting main vessels in the lower extremities

Sayol, R. Rojas; Tarragó, L. Trullols; Blanes, A. Grau; Zaragoza, J. Martinez; Altamirano, Evelyn; Ibañez, A. Peiró; Carro, J.M. Romero; Alegria, Iñaki

doi:10.1016/j.recote.2018.05.003

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…LMS can present as an intravenous tumor of the deep veins. Although vascular LMS is rare, accounting for less than 2% of all LMSs, limited case reports do exist [ 13 – 16 ]. Most vascular LMS cases are located in the iliac vein, as was observed in our patient [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Venous Thromboembolism in Metastatic Uterine Leiomyosarcoma: A Case Report and Review of the Literature

Swisher,

Ornelas,

Ornelas

et al. 2023

Case Rep Oncol

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We report an unusual case of extensive deep vein thrombosis (DVT) and pulmonary embolism (PE) in the setting of metastatic uterine leiomyosarcoma. Recognition of the associated sequelae of this condition may improve short- and long-term outcomes. A 56-year-old black female with a history of uterine leiomyosarcoma diagnosed incidentally after total abdominal hysterectomy for fibroid uterus without initiation of chemoradiation treatment presented to the emergency department complaining of generalized weakness and progressively worsening stridor for 2 weeks. The patient was experiencing shortness of breath, dysphagia, and hoarseness. Physical exam was remarkable for rhonchi but was otherwise normal. Diagnostic imaging via CT of the abdomen, pelvis, and chest revealed DVTs of the left common and external iliac veins, the superior mesenteric artery, multiple pulmonary emboli of the right pulmonary artery, several nodular lesions within the lungs, and scattered peritoneal necrotic lesions, which were suspicious for metastatic disease. Additionally, CT of the neck showed an exophytic mass protruding into the airway from the subglottic region and thyromegaly with bilateral thyroid lobe nodules. The patient was subsequently started on Eliquis and chemotherapy. The rarity of this case is rooted in the extent of the patient’s DVTs and PEs secondary to hypercoagulability in metastatic cancer. This presentation should be further evaluated to exclude thrombophilias or underlying malignancies. Drawing from the lessons of this case will help guide future clinical management regarding the care of metastatic uterine leiomyosarcoma.

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Section: Discussionmentioning

confidence: 99%

Venous Thromboembolism in Metastatic Uterine Leiomyosarcoma: A Case Report and Review of the Literature

Swisher,

Ornelas,

Ornelas

et al. 2023

Case Rep Oncol

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“…Leiomyosarcomas originating from vascular structures are rare, with the most common age of presentation in the sixth and seventh decades [1]. Most of these cases arise from the large veins, such as the inferior vena cava, external iliac vein, femoral vein, and popliteal vein.…”

Section: Discussionmentioning

confidence: 99%

Intravenous Leiomyosarcoma of the Lower Extremity: As Peripheral as It Gets

Umur¹,

Çakmak²,

Isyar³

et al. 2021

Cureus

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Leiomyosarcomas of the vascular system (vLMSs) are rare tumors that commonly originate from large proximal and central veins. Pancreatic metastasis is rare for sarcomas, and surgical excision with large margins is the treatment of choice. We present a case of a 32-year-old female with primary vLMS originating from the distal crural veins and local invasion of the fibula. A prior open biopsy site was suboptimal. The patient was treated with neoadjuvant chemotherapy and radiotherapy, followed by surgery. The follow-up radiological imaging showed pancreatic head metastasis, which is also an extremely rare site for vLMS.

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Leiomyosarcomas affecting main vessels in the lower extremities

Cited by 2 publications

References 16 publications

Venous Thromboembolism in Metastatic Uterine Leiomyosarcoma: A Case Report and Review of the Literature

Venous Thromboembolism in Metastatic Uterine Leiomyosarcoma: A Case Report and Review of the Literature

Intravenous Leiomyosarcoma of the Lower Extremity: As Peripheral as It Gets

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