Leiomyosarcoma Presenting as a Scrotal Mass

Bansal, Devesh; Varghese, Jophy; Babu, Manas; Mehta, Nisarg; Rathore, Ranjeet Singh; Mehta, Sony Bhaskar; Pillai, Biju S; Sam, Mohan P; Moorthy, K

doi:10.1016/j.eucr.2016.04.009

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…The data for adjuvant therapy is limited, though adjuvant radiotherapy has been reported to reduce recurrences in some reports. [1,7] Our patient had a sub centimetric tumour. After discussion, we opted to follow up after surgery with adjuvant therapy.…”

Section: Discussion O F Ma N a G E Me N Tmentioning

confidence: 79%

Recurrent Leiomyosarcoma Scrotum of Dartos Muscle - A Nonplussed Differential in Scrotal Swelling

Phinehas

Authy

2022

jemds

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A 63-year-old gentleman presented with 2 months history of painless, progressively increasing lump on the anterior surface of the left side of the scrotum. He had similar swelling 4 years back at the same site, following which he underwent surgical resection elsewhere and was told to have sarcoma. He could not produce health records of his previous treatment. The lump was a 2 × 2 cm in size subcutaneous in location, on the left hemiscrotum. It was non-tender, firm, and was not fixed to the testis or underlying structures. There was no inguinal lymphadenopathy. Ultrasound of the scrotum revealed a well defined heteroechoeic lesion 2 x2 cm in the left hemiscrotum. A contrast-enhanced computed tomography scan from neck to pelvis showed no distant metastases.

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Section: Discussion O F Ma N a G E Me N Tmentioning

confidence: 79%

Recurrent Leiomyosarcoma Scrotum of Dartos Muscle - A Nonplussed Differential in Scrotal Swelling

Phinehas

Authy

2022

jemds

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“…Adjuvant radiotherapy should be considered when resection with negative margins is not possible. If the possibility of incomplete tumor resection is foreseen, there is a superior oncological benefit from the use of neoadjuvant radiotherapy but with a higher rate of surgical complications and local healing [12,13,14].…”

Section: Discussionmentioning

confidence: 99%

Well-differentiated “lipoma-like” giant paratesticular liposar-coma: a case report

Dubeux

Campos²,

Sobel³

et al. 2022

BJCR

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Few cases of paratesticular liposarcomas have been described in literature and they are considered as rare tumors, especially when they are larger than 10 cm, called giant tumors. We describe the case of a 52-year-old patient diagnosed with a painless mass in the scrotum, initially submitted to magnetic resonance imaging, which revealed a large paratesticular mass. Subsequently, he underwent left radical orchiectomy, which revealed a well-differentiated, “lipoma-like,” “giant” paratesticular liposarcoma. We discussed the workup and current management of this pathology.

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“…The role of RPLND in the management of scrotal and paratesticular soft tissue sarcomas is considered controversial [ 16 ]. Catton et al reported that patients presenting with primary disease had a regional recurrence rate of 28% suggesting that patients with rhabdomyosarcoma, fibrous histiocytoma, or fibrosarcoma may require RPLND [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Testicular, Spermatic Cord, and Scrotal Soft Tissue Sarcomas: Treatment Outcomes and Patterns of Failure

Chowdhry

Kane

Wang

et al. 2021

Sarcoma

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Introduction. Paratesticular sarcomas are defined as tumors that arise within the scrotum and include the subsites of epididymis, spermatic cord, and tunica vaginalis and represent the most common type of GU sarcoma. The mainstay of treatment is often surgical resection, combined with histology specific chemotherapy and radiotherapy. Due to the rare nature of the disease, there are limited data to guide management. We present our single-institution retrospective experience regarding the management and treatment of paratesticular sarcomas. Materials and Methods. We queried our oncology registry database for patients treated for testicular, spermatic cord, and scrotal soft tissue sarcomas between 1971 and 2017. Patients in this series had pathological confirmation of a sarcoma diagnosis by a sarcoma-specialized pathologist. Only patients with localized disease were included in this analysis with the exception of patients with a diagnosis of rhabdomyosarcoma where patients with both localized and metastatic disease were included on this study. Results. A total of 34 patients were included in this retrospective analysis. The median was 24 (range, 5–78), and the median tumor size was 6.25 cm. Twenty-six patients had localized disease (76.6%) at the time of diagnosis. A predominance of patients had tumors involving the spermatic cord (45.5%), and the most common histology was rhabdomyosarcoma (35.3%), leiomyosarcoma (26.5%), and well-differentiated liposarcoma (23.5%). The median follow-up was 71.0 months (range, 2.5–534.4 months). A total of 7 patients experienced an isolated local failure (20.6%), four patients developed distant metastatic disease (11.8%), and one patient (2.9%) with synovial sarcoma of the spermatic cord experienced a regional recurrence. The median progression-free survival (PFS) was 99.6 months, 95% CI (45.8–534.3 months), with a three-year PFS rate of 71%, 95% CI (53%–83%), and a 5-year PFS rate of 64% (range, 46%–78%). We did not find any statistically significant associations based on surgery type ( p = 0.15 ), the use of chemotherapy, ( p = 0.36 ), or final margin status ( p = 0.21 ). Two patients who were treated with preoperative radiotherapy had significant wound healing complication with chronic sinus tracts, though these patients did not experience a local recurrence. Conclusions. We provide a characterization of the natural history and treatment patterns of paratesticular sarcomas. While effective at reducing a local recurrence, preoperative radiotherapy was associated with significant toxicity. As a result, we prefer the use of postoperative radiotherapy in patients as clinically indicated. We did not find any specific treatment patterns associated with an improvement in clinical outcomes.

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Leiomyosarcoma Presenting as a Scrotal Mass

Cited by 5 publications

References 13 publications

Recurrent Leiomyosarcoma Scrotum of Dartos Muscle - A Nonplussed Differential in Scrotal Swelling

Recurrent Leiomyosarcoma Scrotum of Dartos Muscle - A Nonplussed Differential in Scrotal Swelling

Well-differentiated “lipoma-like” giant paratesticular liposar-coma: a case report

Testicular, Spermatic Cord, and Scrotal Soft Tissue Sarcomas: Treatment Outcomes and Patterns of Failure

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