Leiomyosarcoma of the Uterus Metastatic to Brain: A Case Report and a Review of the Literature

Central nervous system leiomyosarcoma in patients with acquired immunodeficiency syndrome

“…The majority of CNS LMSs are metastatic lesions that originate in the gastrointestinal tract or female reproductive system. 16,21,23,34 The incidence of LMS occurring in the neural axis is infinitesimal. Recently, there has been an increasing incidence of primary malignant smooth-muscle tumors in immunocompromised patients.…”

Rectus abdominalis muscle metastasis from uterine leiomyosarcoma: An unusual case and review of the literature

“…It usually occurs de novo, but in some cases, a history of prior irradiation may be present (5). The tumor spreads most commonly by hematogenous route to the lung (6), thyroid (7), liver (6, 8), brain (9), and bone (6,10). Bronchogenic carcinoma, breast carcinoma, melanoma, and gastrointestinal and urinary tract tumors commonly metastasize to skeletal muscle, but it is an unexpected site of metastasis of leiomyosarcoma (5).…”

“…The tumor primarily metastasizes hematogenously. Spread to the lung (6), thyroid (7), liver (6,8), brain (9), and bone (6, 10) has been reported. To the best of our knowledge, there are two cases of skeletal muscle metastasis of uterine leiomyosarcoma reported in the literature (5,11).…”

Central Nervous System Involvement Secondary to Metastatic Mixed Müllerian Tumor of the Uterus

“…Iqbal and Ironside [6] reported a 52-year-old woman who, after resection of a cerebral metastasis from a malignant mixed miillerian tumor, was still alive at 25 months postcraniotomy and 30 months post-TAH-BSO. Recently, Wronski et al [11] reported a case of uterine leiomyosarcoma metastatic to the brain and extensively reviewed the literature on this subject. They found 7 pre viously reported cases of leiomyosarcoma and 2 cases of endometrial stromal sarcoma metastatic to the brain.…”