Leiomyosarcoma of the uterine cervix in a young woman

Sahu, Latika; Bupathy, A.; Badhe, Bhavana

doi:10.1111/j.1447-0756.2008.00914.x

Cited by 10 publications

(10 citation statements)

References 6 publications

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“…4 However, the use of postoperative radiation therapy may reduce the pelvic relapse rate by~50% and should be considered in patients at high risk for local recurrence (tumors >5 cm, high mitotic index, and high grade tumors). 7 Most patients with advanced disease are considered candidates for chemotherapy due to this tumor's tendency to metastasize hematogenously. Several chemotherapy regimens have been considered for patients with advanced leiomyosarcoma of the uterus, including doxorubicin and ifosfamide, single-agent paclitaxel, and a combination of paclitaxel and carboplatin.…”

Section: Discussionmentioning

confidence: 99%

Localized leiomyosarcoma of the uterine cervix with rapid lung metastases

Casanova

Huang

Thepsuwan

et al. 2015

Gynecology and Minimally Invasive Therapy

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Keywords: immunohistochemistry leiomyosarcoma lung metastases smooth muscle cells uterine cervix a b s t r a c t Cervical sarcomas are extremely rare tumors associated with a poor prognosis. We report the case of a 63-year-old woman who was admitted to our institution due to abnormal vaginal bleeding and abdominal pain. Physical examination revealed a large cervical mass that was biopsied. Pathological features were compatible with a leiomyosarcoma of the uterine cervix. The patient underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy. All histological and Immunohistochemical findings confirmed the diagnosis of leiomyosarcoma of the cervix. Adjuvant chemotherapy was started but unfortunately the disease progressed and 1 year after completion of the chemotherapy the patient developed lung metastases and eventually died. IntroductionPrimary sarcomas of the cervix are extremely rare neoplasms. Due to the relative infrequency of this disease, there is a paucity of reports in the literature and the available data regarding the natural history of cervical sarcomas derive from case reports. 1e7 To date, Bansal et al 1 have published the largest series, the authors identified 323 patients with cervical sarcomas from a total of 33,074 women with invasive cervical neoplasms. Among cervical sarcomas, leiomyosarcomas are exceedingly rare. In the literature, they account for 21% of all cervical sarcomas, representing roughly 0.21% of all invasive cervical cancer cases. 1 We present an unusual case of a cervical leiomyosarcoma with lung metastasis in a postmenopausal woman. Case ReportA postmenopausal 63-year-old woman, Gravida 9/Para 8 (gravidity/parity) (G9P8), presented to the outpatient department with complaints of worsening lower abdominal pain of~1 month duration. Pelvic examination revealed a large cervical mass and a moderately enlarged uterus (~10 weeks gestation size). A biopsy of the mass was obtained and the pathology report revealed findings compatible with leiomyosarcoma. The endometrial stripe was very difficult to assess by transvaginal ultrasound due to the size of tumor.Magnetic resonance imaging (MRI) showed a large tumor involving the uterine corpus and cervix, the right parametrium and the paracervical area, measuring 11 Â 11 Â 14 cm (Fig 1A). A positron emission tomography scan (PET) demonstrated only an isolated increased uptake of the radioactive tracer confined to the lower pelvis. No distant metastases were evident. Laboratory studies including CA-125 were within normal limits.The patient underwent an exploratory laparotomy. No evidence of ascites, retroperitoneal lymphadenectomy, or metastatic spread

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Section: Discussionmentioning

confidence: 99%

Localized leiomyosarcoma of the uterine cervix with rapid lung metastases

Casanova

Huang

Thepsuwan

et al. 2015

Gynecology and Minimally Invasive Therapy

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“…Previously, a leiomyosarcoma, which arose in the cervix of a young woman, was reported with rapid extension and poor prognosis. 8 Considering our case, the primary could have been a leiomyosarcoma that arose primarily in the cervix.…”

Section: Discussionmentioning

confidence: 83%

“…At the time our patient was undergoing treatment, doxorubicin‐based treatment was considered one of the standard therapies for leiomyosarcoma 8,9 . but the efficacy and safety had not been established.…”

Section: Discussionmentioning

confidence: 99%

“…At the time our patient was undergoing treatment, doxorubicin-based treatment was considered one of the standard therapies for leiomyosarcoma. 8,9 but the efficacy and safety had not been established. On the other hand, VAC therapy 3 is the standard regimen for rhabdomyosarcomas in infancy, 10 thus we decided to try VAC therapy initially, with the expectation that in so doing death would occur in the rhabdomyosarcoma part of the tumor.…”

Section: Discussionmentioning

confidence: 99%

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A case of tumor lysis syndrome following chemotherapy for a uterine epithelioid leiomyosarcoma with focal rhabdomyosarcomatous differentiation

Hiraizumi¹,

Kamoi²,

Inde³

et al. 2011

J of Obstet and Gynaecol

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Tumor lysis syndrome (TLS) is a potential complication characterized by hyperuricemia, hyperphosphatemia, hyperkalemia and hypocalcemia due to massive necrosis of malignant cells after cytotoxic therapy. This fatal complication occurs frequently in tumors with hematological malignancies, such as acute lymphoblastic leukemia and Burkitt's lymphoma, and in other tumors with high proliferative rates and tumor burdens. TLS is rarely associated with the treatment of solid tumors. Herein, we report a case of TLS following the initial administration of effective chemotherapy for an epithelioid leiomyosarcoma with focal rhabdomyosarcomatous differentiation of the uterus.

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“…Most epithelioid leiomyosarcomas occur in the uterine body. Only five cases of this tumour affecting the uterine cervix have been reported in the English literature [1][2][3][4][5] Our objective is to report the clinical and pathological findings, treatment and outcome of Epithelioid leiomyosarcoma of the cervix case of our case and to review the related literature.…”

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confidence: 97%

Epithelioid leiomyosarcoma of the uterine cervix: a case report and review of the literature

et al. 2012

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Background : Epithelioid leiomyosarcoma arising from the uterine cervix is extremely rare, with only few cases reported in the world literature Case presentation : The case concerns a 41-year-old female patient who was admitted to our hospital, with worsening menorrhagia during the past 6 months. Pelvic examination revealed a large tumour of the uterine cervix extended into the upper vagina. Pelvic magnetic resonance imaging confirmed the presence of a cervical uterine tumour. Cervical biopsy and immunohistological study concluded leiomyosarcoma (grade 2). Radiological workup revealed the presence of pulmonary metastasis. A bilateral nephrostomy was performed before treatment because of obstructive renal failure. The treatment of this case consisted of ifosfamide and doxorubicin-based chemotherapy. After three cycles, the assessment of the disease showed partial response. The treatment was continued for three other cycles. But, the second evaluation of the patient revealed tumour progression. The treatment was then stopped, and best supportive care was provided. The patient is still alive. Conclusion : Although exceedingly rare, leiomyosarcoma can arise on the uterine cervix. Management of cervical leiomyosarcoma is extrapolated from the currently accepted management of uterine leiomyosarcoma. It is difficult to develop optimal management strategies and to predict prognosis of the disease. Pour citer cette revue : J. Afr. Cancer 4 (2012).Keywords Leiomyosarcoma · Uterine cervix · Chemotherapy · Cervical biopsy Résumé Introduction: Le léiomyosarcome épithélioïde du col utérin est une tumeur extrêmement rare, avec seulement quelques cas rapportés dans la littérature mondiale. Cas clinique: Il s'agit d'une patiente de 41 ans admise dans notre hôpital pour métrorragies datant de six mois. L'examen gynécologique a retrouvé une grosse tumeur du col utérin étendue à la partie supérieure du vagin. L'imagerie par réso-nance magnétique a confirmé la présence d'une tumeur du col utérin. La biopsie cervicale avec étude immunohistochimique a conclu : un léiomyosarcome (grade 2). Le bilan d'extension radiologique a révélé la présence de métastases pulmonaires. Une néphrostomie bilatérale a été réalisée avant le traitement en raison d'une insuffisance rénale obstructive. Le traitement de ce cas consistait en une chimiothérapie à base d'ifosfamide et de doxorubicine. Après trois cycles, l'évaluation de la maladie a montré une réponse partielle. Le traitement a été poursuivi pendant trois autres cycles. Mais, la seconde évaluation de la patiente a révélé une progression tumorale. Le traitement a été arrêté et la malade a été confiée aux soins palliatifs. La patiente est actuellement toujours en vie. Conclusion: Bien que très rare, un léiomyosarcome peut survenir au niveau du col utérin. Le traitement du léiomyosar-come du col utérin est extrapolé sur le traitement du léiomyo-sarcome du corps utérin. Il est difficile d'élaborer des stratégies thérapeutiques optimales et de prédire le pronostic de la maladie.

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Leiomyosarcoma of the uterine cervix in a young woman

Cited by 10 publications

References 6 publications

Localized leiomyosarcoma of the uterine cervix with rapid lung metastases

Localized leiomyosarcoma of the uterine cervix with rapid lung metastases

A case of tumor lysis syndrome following chemotherapy for a uterine epithelioid leiomyosarcoma with focal rhabdomyosarcomatous differentiation

Epithelioid leiomyosarcoma of the uterine cervix: a case report and review of the literature

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