Leiomyosarcoma of the Prostate

Mottola, A; Selli, Cesare; Carini, Marco; Natali, Alessandro; Gambacorta, G

doi:10.1159/000472471

Cited by 11 publications

(13 citation statements)

References 8 publications

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“…Rhabdomyosarcoma is the more common form and occurs primarily in children and adolescents [2,3]. Leiomyosarcomas represent 25% of all prostatic sarcomas and are more likely to occur in older men [4]. Both types of tumors are nearly always massive at presentation and tend to expand toward the bladder, whereas metastases occur mainly to lymph nodes.…”

mentioning

confidence: 99%

Rhabdomyosarcoma of the prostate: MR findings

Bartolozzi

Selli²,

Olmastroni³

et al. 1988

American Journal of Roentgenology

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mentioning

confidence: 99%

Rhabdomyosarcoma of the prostate: MR findings

Bartolozzi

Selli²,

Olmastroni³

et al. 1988

American Journal of Roentgenology

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“…LMS is rare, comprising only <0.1% of prostatic malignancies 51–56 . Although LMS is infrequent, LMS and rhabdomyosarcoma (RMS) represent the most predominant types of adult prostate sarcoma in reported series.…”

Section: Smooth Muscle Tumourmentioning

confidence: 99%

“…Although LMS is infrequent, LMS and rhabdomyosarcoma (RMS) represent the most predominant types of adult prostate sarcoma in reported series. Prostatic LMS usually occurs in the fourth to seventh decades of life, but may also occur in young adults and paediatric patients 51–56 . In one review series, eight (12%) of 57 LMS patients were <10 years of age 54 .…”

Section: Smooth Muscle Tumourmentioning

confidence: 99%

“…In one review series, eight (12%) of 57 LMS patients were <10 years of age 54 . Obstructive urinary symptoms constitute the most common presentation; other symptoms include perineal pain, constipation from a local mass effect, haematuria, and weight loss 51–56 …”

Section: Smooth Muscle Tumourmentioning

confidence: 99%

“…Radical surgery is a treatment option, but it is often difficult to completely resect the tumour. Nearly half of patients with resected tumours have gross residual disease after surgery 51–56 . In the series by Cheville et al.…”

Section: Smooth Muscle Tumourmentioning

confidence: 99%

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Non‐epithelial neoplasms of the prostate

et al. 2011

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Non-epithelial prostatic neoplasms are infrequent and cover a broad array of entities that include both benign and highly aggressive tumours. Because they are very infrequent, there is often limited understanding of them, and the recognition of these entities, when encountered, may pose a diagnostic challenge, owing to histological overlap between them or their rarity. Most lesions in this category are mesenchymal in origin, such as prostatic stromal tumours arising from specialized prostatic stroma, smooth muscle tumours, both benign and malignant, and solitary fibrous tumours. Less commonly occurring tumours include neural, germ cell and melanocytic tumours that may be derived from cells not normally present in the prostate. Some tumours have well-established extraprostatic counterparts and, when encountered, are more commonly extraprostatic/secondary in origin; these include gastrointestinal stromal tumours and most haematopoietic tumours. The majority of tumours are characterized by a spindle cell pattern with significant overlap in morphological features. In this setting, appropriate use of immunohistochemistry and molecular studies are often necessary for accurate diagnosis, prognosis, or prediction for therapy. This review addresses and updates the clinicopathological features of the entire spectrum of non-epithelial tumours with an approach to the histological diagnosis.

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Leiomyosarcoma of the prostate. Report of 23 cases

Cheville

Dundore

Nascimento

et al. 1995

Cancer

110

101

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Background. Leiomyosarcoma of the prostate is a rare neoplasm that accounts for less than 0.1% of prostate malignancies. Previous reports of this neoplasm consisted of single case studies or small series, often combined with cases of rhabdomyosarcoma. The relationship of prognosis with histologic and immunohistochemical findings has not, to the authors' knowledge, been described in a large series of cases, and the efficacy of various treatments is uncertain. Methods. The authors undertook a clinicopathologic study of all cases of prostate leiomyosarcoma observed at their institution from 1929 to 1994. Twenty‐three cases were retrieved from the files of the Department of Pathology, Mayo Clinic (Rochester, MN), and clinical follow‐up was available for 14. Immunohistochemical studies, including actin, desmin, S‐100 protein, keratin, and vimentin were performed for 18 cases. Results. Patients ranged in age from 41 to 78 years, with a mean of 61 years. Presenting symptoms included urinary obstruction (100%), perineal pain (25%), burning on ejaculation (7%), and weight loss (7%). The neoplasms ranged from 3.3 to 21 cm (mean, 9 cm) in greatest dimension and were often associated with necrosis. Seven tumors were Grade 2, 10 Grade 3 and 6 Grade 4 (Broders' grading system; scale, 1–4). Mitotic figure counts varied from 2 to 24 per 10 high power fields. Fifteen of 15 (100%) cases were immunoreactive for vimentin, 10 of 16 (63%) were immunoreactive for actin, and 3 of 15 (20%) were weakly reactive for desmin. Keratin expression was observed in 4 of 15 cases (27%), and S‐100 protein was negative in all cases. Treatment varied, and usually included a combination of radiation therapy, chemotherapy, and radical prostatectomy or cystoprostatecomy. Follow‐up ranged from 2 to 72 months, with a mean of 19 months. Ten patients died from tumor 3 to 72 months (mean, 22 months) after diagnosis. Four patients were alive, including three with residual tumor and one without evidence of tumor at 2, 4, 30, and 4.5 months, respectively. Local recurrence occurred in 10 of 11 patients, including 5 who had gross residual tumor present after surgery. Metastases developed up to 40 months after surgery (mean, 10.3 months), and most frequently involved the lungs. Conclusions. These findings indicate that prostate leiomyosarcoma has a varied histologic appearance ranging from spindled cell neoplasm reminiscent of smooth muscle to pleomorphic sarcoma. Epithelioid features may be present. Most tumors are immunoreactive with antibodies to vimentin and actin, and reactivity with antikeratin antibodies does not exclude the diagnosis of leiomyosarcoma. Prostate leiomyosarcoma has a poor prognosis, although the length of survival is variable. Radical surgery was the treatment of choice in the current series, but complete excision was difficult in most cases and did not result in cure.

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Leiomyosarcoma of the Prostate

Cited by 11 publications

References 8 publications

Rhabdomyosarcoma of the prostate: MR findings

Rhabdomyosarcoma of the prostate: MR findings

Non‐epithelial neoplasms of the prostate

Leiomyosarcoma of the prostate. Report of 23 cases

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