Leiomyosarcoma of the Penis

Elem, B.; Nieslanik, J.

doi:10.1111/j.1464-410x.1979.tb04244.x

Cited by 9 publications

(5 citation statements)

References 3 publications

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“…Of the 7 patients, 3 were treated with initial limited excision or partial penectomy and then experienced local recurrence or distant metastasis. 7,13,14,23 This supports the use of radical surgery in large, deep tumors. In an additional 4 cases, metastasis occurred despite initial treatment with total penectomy and use of adjuvant chemoradiation therapy.…”

Section: Characteristics Resultsmentioning

confidence: 57%

“…Most patients in our review had asymptomatic, slow-growing lesions for 6 to 24 months before presentationincluding our patient-while others had an aggressive tumor with symptoms for a few weeks followed by rapid metastatic spread. 6,7…”

Section: Discussionmentioning

confidence: 99%

“…10 In our review, more conservative approaches to deep tumors were associated with local recurrences. 7,13,14 Lymphatic spread is rare for LMS. Additionally, involvement of local lymph nodes usually coincides with distant spread.…”

Section: Treatmentmentioning

confidence: 99%

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Leiomyosarcoma of the Penis: A Case Report and Re-Appraisal

Ajmal¹

2022

Federal Practitioner

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Background: Penile leiomyosarcoma arises from smooth muscles, which can be from dartos fascia, erector pili in the skin covering the shaft, or from tunica media of the superficial vessels and cavernosa. We describe presentation, treatment options, and recurrence pattern of this rare malignancy. Case Presentation: We present a case of penile leiomyosarcoma in a 70-year-old patient who presented to the urology clinic with 1-year history of a slowly enlarging penile mass associated with phimosis.Conclusions: Prognosis of penile LMS is difficult to ascertain because reported cases are rare. Penile leiomyosarcoma can be classified as superficial or deep based on tumor relation to tunica albuginea. Deep tumors (> 3 cm), high-grade lesions, and tumors with involvement of corpora cavernosa, tend to spread locally and metastasize to distant areas and require more radical surgery with or without postoperative radiation therapy. In contrast, superficial lesions can be treated with local excision only.

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Section: Characteristics Resultsmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

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Leiomyosarcoma of the Penis: A Case Report and Re-Appraisal

Ajmal¹

2022

Federal Practitioner

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“…Leiomyosarcoma of the penis is very rare, with <30 cases documented in the English language literature over the past half century. [1][2][3][4][5][6][7][8]11,13,14,[16][17][18][19][20][22][23][24][25][26][27]29,30,33 Nevertheless, this represents the second most common primary sarcoma type of this anatomic location (after Kaposi sarcoma) in the Armed Forces Institute of Pathology files.…”

Section: Discussionmentioning

confidence: 99%

“…While there is reason to be skeptical of the diagnosis in a few instances, we have given all remaining authors benefit of the doubt and feel the few possible outliers probably minimally impact on the overall picture. We noted eight patients who presented with superficial tumors, 1,[3][4][5]17,19,27,30,33 12 patients with deep-seated tumors, 2,[6][7][8]13,18,[22][23][24][25][26]29 and five patients with tumors of uncer-tain depth. 5,11,14,16,20 The mean ages for these patient groups were 42 years, 56 years, and 66 years, respectively.…”

Section: Discussionmentioning

confidence: 99%

Leiomyosarcoma of the Penis

Fetsch

Davis²,

Miettinen³

et al. 2004

The American Journal of Surgical Pathology

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Primary leiomyosarcomas of the penis are very rare. To date, less than 30 have been documented in the English language literature. In this report, we describe the clinical, histopathologic, and immunohistochemical findings in 14 cases retrieved from our files. The patients ranged in age from 43 to 62 years (mean age, 51 years) at the time of initial surgical resection. The tumors involved the prepuce (n = 1), prepuce and distal shaft (n = 1), circumcision scar line (n = 2), circumcision scar line and distal shaft (n = 1), shaft (n = 5), base of the penis (n = 3), and penis, not otherwise specified (n = 1). The lesions ranged in size from 0.5 to 6.0 cm (median size, 1.5 cm) in greatest dimension. Nine tumors were superficially located, two were of indeterminate depth, and three were deep-seated. The superficial tumors were relatively asymptomatic, and seven were reportedly present for 1 year to more than 20 years (median duration, 5 years) before medical attention was sought. In contrast, one deep-seated lesion caused dysuria and difficulty voiding, prompting the patient to seek a clinical opinion within only a few months of the apparent onset. Histologically, all tumors contained smooth muscle cells with both cytologic atypia and mitotic activity. Immunohistochemical studies were available for nine tumors, and immunoreactivity for desmin was present in all instances. All patients were initially treated with a local procedure. Follow-up information is available for 9 of the 14 patients (64%), with a median follow-up interval of 12 years 11 months. Three patients had multiple (two to four) local recurrences. Two of these patients were ultimately treated with a wide local excision or partial penectomy, and both were alive and well at last follow-up. In contrast, one patient, who had four local recurrences and refused a penectomy, developed a distant metastasis 10 months after the fourth recurrence. The best predictors of outcome are tumor depth and tumor size. Superficial leiomyosarcomas of the penis are optimally managed by wide local excision whenever this is technically feasible. Tumors with a deep-seated component may require more aggressive intervention to ensure complete removal.

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Leiomyosarcoma of the penis. Case report and review of the literature

Isa

Almaraz

Magovern

1984

Cancer

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The twenty‐third case of penile leiomyosarcoma in the literature is reported, and all cases are reviewed. Clinically and pathologically these tumors fall into two groups, superficial and deep. Superficial tumors grow slowly, and tend to recur locally, but have a high salvage rate and good prognosis. The recommended treatment is local excision with negative margins. Recurrences are usually amenable either to re‐excision or amputation with some degree of success. Deep tumors exhibit a more aggressive behavior, and have a poorer prognosis. Despite radical surgery the salvage rate is low, and most patients die from disseminated disease one or two years after diagnosis. Metastases to inguinal lymph nodes are uncommon, and should be treated aggressively in the absence of distant metastases. The role of adjuvant radiotherapy and chemotherapy in treating deep tumors should be investigated.

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Leiomyosarcoma of the Penis

Cited by 9 publications

References 3 publications

Leiomyosarcoma of the Penis: A Case Report and Re-Appraisal

Leiomyosarcoma of the Penis: A Case Report and Re-Appraisal

Leiomyosarcoma of the Penis

Leiomyosarcoma of the penis. Case report and review of the literature

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