Leiomyosarcoma of the Nose and Paranasal Sinuses

Josephson, R L; Blair, Robin; Bédard, Yvan C.

doi:10.1177/019459988509300228

Cited by 34 publications

(33 citation statements)

References 9 publications

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“…Immunohistochemistry shows positive staining for vimentin and smooth muscle actin. Leiomyosarcoma of the temporal bone can arise from the smooth muscle cells surrounding the vascular endothelium, can occur secondary to metastatic disease, or can arise from aberrant undifferentiated mesenchyme (1,3). The tumor metastasizes hematogenously.…”

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confidence: 99%

Leiomyosarcoma of the Temporal Bone

Ursick

Linthicum

2011

Otology &Amp; Neurotology

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confidence: 99%

Leiomyosarcoma of the Temporal Bone

Ursick

Linthicum

2011

Otology &Amp; Neurotology

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“…The mean age at the onset of leiomyosarcoma in the nasal and paranasal sinus areas was shown to be 53.2 AE 18.6 years, but this tumor has been observed over a wide age range from 18 to 87 years [3][4][5] . The male/female ratio is almost 1:1, showing no sex-related differences.…”

Section: Discussionmentioning

confidence: 99%

Leiomyosarcoma arising in the nasal cavity

Kudo¹,

Suzaki²

2013

Grand Rounds

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We report a rare case of leiomyosarcoma arising in the nasal cavity. A 45-year-old woman visited our hospital because of recurrent epistaxis in 1998. A biopsy was performed on a mass in the posterior area of the left nasal cavity, and a histological diagnosis of leiomyosarcoma was made. Although the nasal tumor was resected via left lateral rhinotomy, tumor recurrence was detected. In addition, multiple metastatic tumors were detected in both lungs. Therefore, CyberKnife therapy was performed for the recurrent tumor and radiofrequency ablation for a large tumor among the metastatic lung tumors. Although the patient died of multiple metastasis of the whole body in 2007, tumors in the lungs and the primary site, which were treated with radiofrequency ablation and CyberKnife therapy, did not increase. Leiomyosarcoma has a poor prognosis, and when recurrence or distant metastasis occurs, radical cure is even more difficult. In this patient, CyberKnife therapy and radiofrequency ablation were effective for treating local recurrent and metastatic lesions. Even in patients in whom a radical cure is difficult due to recurrence or distant metastasis, CyberKnife therapy and radiofrequency ablation can relieve symptoms and prolong survival.

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“…2 High differentiation of tumor cells, minimum pleomorphism and the low degree of mitotic activity indicate that this is a benign tumor. 3 Josephson et al 4 studied six cases of leiomyosarcoma present within benign tumors. This indicates the possibility of a benign tumor becoming a leiomyosarcoma.…”

Section: Discussionmentioning

confidence: 99%