Leiomyosarcoma of the chest wall with cutaneous metastases to the scalp in a patient with systemic sclerosis

Banka, Nusrat; Alfadley, Abdullah

doi:10.1111/j.1468-3083.2006.01550.x

Cited by 4 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even though leiomyosarcoma is prone to metastasize, cutaneous metastases are extremely rare, usually occurring late in the course of the disease and usually associated with metastases to internal organs . To our knowledge, 50 cases of cutaneous metastasis from soft tissue leiomyosarcoma of any non‐gynecologic anatomic site have been reported in the literature with only 11 of these cases being metastasis to the scalp region . Just two of these scalp metastases were from retroperitoneal leiomyosarcoma, the scenario most similar to our case .…”

Section: Discussionsupporting

confidence: 73%

Cutaneous scalp metastases from retroperitoneal leiomyosarcoma: a case report

et al. 2014

View full text Add to dashboard Cite

A 71-year-old woman presented with five scalp nodules that were clinically suspicious for pilar cysts. Histopathologic examination showed a proliferation of mitotically active pleomorphic spindle cells arranged into intersecting fascicles in the dermis and subcutis. Tumor cells displayed deeply eosinophilic cytoplasm and expressed desmin but were negative for S100 protein by immunohistochemistry. Before 10 years, the patient was diagnosed with high-grade retroperitoneal leiomyosarcoma and underwent resection with intraoperative radiation. Metastatic disease involving the lungs, liver and soft tissue developed, requiring treatment with resections, radiation and chemotherapy. Owing to the presentation of multiple scalp nodules with microscopic features of leiomyosarcoma in conjunction with the clinical history of retroperitoneal leiomyosarcoma, a diagnosis of metastatic leiomyosarcoma was made. Scalp metastasis from retroperitoneal leiomyosarcoma is extremely rare and portends a poor prognosis. To our knowledge, only two other cases have been reported in the English literature, and a further search discovered only nine additional cases of scalp metastasis from soft tissue leiomyosarcoma of any non-gynecologic anatomic site. This case highlights the striking microscopic similarity between primary cutaneous and metastatic leiomyosarcoma and illustrates the necessity of adequate clinical information and an appropriate index of suspicion in excluding the possibility of cutaneous metastases of leiomyosarcoma from somatic soft tissue.

show abstract

Section: Discussionsupporting

confidence: 73%

Cutaneous scalp metastases from retroperitoneal leiomyosarcoma: a case report

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Skin metastases from mesenchymal tumors are rare. [1][2][3][4][5][6] Unlike their carcinomatous counterparts, the majority of sarcomas do not metastasize to lymph nodes, preferring hematogenous spread to visceral organs. We examined our institutional experience with pathologically confirmed sarcoma metastases to the skin, including the distribution, type, and prognostic implications.…”

Section: Introductionmentioning

confidence: 99%

Sarcoma metastases to the skin

Wang

Bones-Valentin

Prieto

et al. 2011

Cancer

View full text Add to dashboard Cite

BACKGROUND: Sarcoma metastases to the skin are relatively rare, because most involve the lung, liver, or deep soft tissues. The authors of this report examined the distribution and clinical significance of cutaneous and superficial subcutaneous sarcoma metastases. METHODS: Sixty-five patients with histologically confirmed dermal and superficial subcutaneous sarcoma metastases were identified in pathology files from more than 25,000 patients with sarcoma who were evaluated at The University of Texas M. D. Anderson Cancer Center from 1989 to 2009. Pathology slides and clinical and radiological information were evaluated. RESULTS: Cutaneous metastases were documented histologically in <0.25% of patients. The mean patient age was 49 years (range, 16-79 years), and there was an equivalent ratio of men to women. The most common source of metastasis was leiomyosarcoma (28 of 65 patients; 43%). The most common region of first skin metastasis was head and neck (33 patients; 51%), and the scalp predominated (25 patients; 38%). The mean time from primary tumor diagnosis to skin metastasis was 48 months (range, 0-166 months). Fifty-three patients (81%) had multiple metastases (skin and other). Among the patients who had complete clinical information available, 31 patients (62%) had other metastases diagnosed before skin involvement, 17 patients (34%) had skin metastases diagnosed first, and 2 patients (4%) had simultaneous presentation. The following clinical outcomes were documented: Twenty-nine patients (45%) died of disease, 24 patients (37%) remained alive with disease, and 12 patients were lost to follow-up. The mean time to death was 80 months (range, 9-224 months) after primary diagnosis, 45 months (range, 5-94 months) after the first metastasis to any site, and 27 months (range, 5-65 months) after the first skin metastasis. CONCLUSIONS: Sarcoma metastases to the skin are rare. In this large study, leiomyosarcoma was the most common source, and the scalp was the most frequent site. The majority of patient with skin metastases harbored metastases elsewhere. However, skin was the initial site of metastasis in approximately 1 in 3 patients. Thus, clinical correlation is needed before establishing a diagnosis of primary cutaneous sarcoma, particularly leiomyosarcoma of scalp. Finally, the current results indicated that skin metastasis usually is a late event in sarcoma clinical progression and heralds a poor prognosis.

show abstract

36 Tumors of muscle, cartilage, and bone

2010

Weedon's Skin Pathology

View full text Add to dashboard Cite

Leiomyosarcoma of the chest wall with cutaneous metastases to the scalp in a patient with systemic sclerosis

Cited by 4 publications

References 8 publications

Cutaneous scalp metastases from retroperitoneal leiomyosarcoma: a case report

Cutaneous scalp metastases from retroperitoneal leiomyosarcoma: a case report

Sarcoma metastases to the skin

36 Tumors of muscle, cartilage, and bone

Contact Info

Product

Resources

About