Leiomyosarcoma of gingiva: Report of a case and review of the literature

Leiomyosarcomas of the oral cavity: an unusual topographic subset easily mistaken for nonmesenchymal tumours

“…46,47 While leiomyosarcomas may show positive staining for S100 protein, 48,49 this is quite rare; although one of our 10 cases was positive for S100 protein, no positivity was found in 11 previously reported oral leiomyosarcomas. 4,5,16,21,23,24,33,36,38 Furthermore, the combination of S100 protein, cytokeratin and myogenic marker positivity would be exceptional in leiomyosarcoma.…”

Primary oral leiomyosarcoma: a clinico-pathologic study and analysis of prognostic factors

“…In contrast, primary LMS of the oral cavity is exceedingly rare, a finding attributed to the general paucity of smooth muscle in this location 9 . There have been about 65 cases reported in the English literature since 1950, often as individual case studies [1][2][3][4][5][7][8][9][10][12][13][14][16][17][18][19][20][21][22][23][24][25][26][27][28][30][31][32][33][34][35][36][37][38][39][40]42,43,45,47 . Diagnosis of these lesions can be difficult on routine histology alone, and earlier reports were frequently diagnosed without immunohistochemical confirmation [1][2][3]9,13,17,19,…”

Leiomyosarcoma of the buccal mucosa: a case report with immunohistochemistry findings

“…For this reason special stains, and above all immunohistochemistry, play a very important role in diagnosis (16). Early wide surgical excision with radical neck dissection for lymph node metastasis remains the mainstay of treatment (17). Requests for conservative surgical excision to preserve the facial appearance of young patients need to be considered, based on full disclosure of the known behavior of LMS and its nearly certain recurrence after anything less than aggressive initial surgery.…”