Leiomiomatosis cutánea y uterina múltiple o síndrome de Reed: estudio retrospectivo de 13 casos

Collgros, Helena; Iglesias‐Sancho, Maribel; Tribó-Boixareu, M.J.; Creus-Vila, L.; Umbert-Millet, P.; Salleras-Redonnet, Montse

doi:10.1016/j.ad.2014.08.005

Cited by 22 publications

(10 citation statements)

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“…No evidence of renal cell carcinoma was detected. [ 4 ] This was similar to our case where screening for renal involvement revealed a benign renal cyst.…”

Section: Discussionsupporting

confidence: 88%

“…Reed's syndrome may be associated with renal malignancy, and the resulting condition is known as hereditary leiomyomatosis and renal cell cancer (HLRCC). [ 4 ]…”

Section: Discussionmentioning

confidence: 99%

“…Patients with multiple CLs should be screened for noncutaneous manifestations. [ 4 6 ] Although the association of Reed's syndrome with renal cyst may be coincidental, considering the previous reports, further association between the two needs to be determined.…”

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemical staining is positive for smooth muscle markers including actin and desmin. [ 4 ]…”

Section: Introductionmentioning

confidence: 99%

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Multiple cutaneous and uterine leiomyomatosis with renal involvement: Report of a rare association

Gupta

Sudan²,

Mushtaq³

2018

Indian J Dermatol

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Cutaneous leiomyomas (CLs) are uncommon benign smooth muscle tumours characterised by solitary or multiple painful nodules. Based on origin, three types are recognised, namely piloleiomyoma, dartoic leiomyoma, and angioleiomyoma, with piloleiomyomas being the commonest one. Reed's syndrome also known as multiple cutaneous and uterine leiomyomatosis (MCULs) is characterised by CLs in men and CLs and uterine fibroids in women. Association of Reed's syndrome with renal cell carcinoma is labelled as hereditary leiomyomatosis and renal cell carcinoma (HLRCC). Both MCUL and HLRCC are caused by a heterozygous mutation in the fumarate hydratase gene. Besides renal cell carcinoma, there were extremely rare reports of association of MCUL with benign renal lesions. We report a case of a 55-year-old female with segmental tender papulonodular lesions suggestive of leiomyoma associated with uterine leiomyomas and unilateral renal cyst. The case is reported here for its rarity and uncommon association with asymptomatic benign renal cyst.

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“…No evidence of renal cell carcinoma was detected. [ 4 ] This was similar to our case where screening for renal involvement revealed a benign renal cyst.…”

Section: Discussionsupporting

confidence: 88%

“…Reed's syndrome may be associated with renal malignancy, and the resulting condition is known as hereditary leiomyomatosis and renal cell cancer (HLRCC). [ 4 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemical staining is positive for smooth muscle markers including actin and desmin. [ 4 ]…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Multiple cutaneous and uterine leiomyomatosis with renal involvement: Report of a rare association

Gupta

Sudan²,

Mushtaq³

2018

Indian J Dermatol

View full text Add to dashboard Cite

show abstract

“…El síndrome de Reed o leiomiomatosis cutánea y uterina múltiple es una enfermedad rara, de herencia autosómica dominante, que se caracteriza por la presencia de leiomiomas cutáneos y uterinos, y en un subgrupo de pacientes, carcinoma de células renales 1 . Este síndrome se produce por una mutación heterocigótica del gen que codifica la fumarato hidratasa, un enzima del ciclo de Krebs que actúa como supresor tumoral 2 .…”

Section: Discussionunclassified