Legume intake and the risk of cancer: a multisite case–control study in Uruguay

Asian Pacific J Cancer Prev, 13 (9), 4677-4681 IntroductionProstate cancer is the most common cancer among men in United States. It is also one of the leading causes of cancer death among men of all races (Siegel et al., 2012). Although age and family history have been established as strong risk factors for prostate cancer, the role of individual dietary factors is not well understood. The large variation in incidence across countries may also suggest the role of lifestyle and dietary factors in its cause (Yu et al., 1991). Eggs are frequently consumed worldwide, supply substantial portions of protein, fat, retinal, riboflavin and iron. Eggs are also unique among foods, given their relatively high content of several substances, such as cholesterol, choline, biotin, and avidin. There is evidence pointing to a possible role of eggs consumption on cancer etiology. A positive association has been observed between eggs consumption and risk of colorectal cancer (Steinmetz et al., 1994). For other cancer sites, there is no established association with eggs. Several studies considered the relation between eggs intake and prostate cancer. Though most of them reported no association, results were often inconsistent. With the aim to investigate the relationship between prostate cancer and eggs consumption, we carried out a meta-analysis of epidemiological studies published up to July 2012. Materials and MethodsA systematic literature search was carried out in the AbstractObjective: Egg consumption has been suggested to increase the risk of colorectal and some other cancers. The present study summarized and quantified the current evidence relating dietary intake of eggs and prostate cancer. Materials and methods: Literature searches were conducted to identify peer-reviewed manuscripts published up to July 2012. Twenty manuscripts from nine cohort studies and 11 case-control studies were identified. Summary risk estimates with 95% confidence intervals (CIs) were calculated for case-control and cohort studies separately. Results: Neither the case-control not the cohort studies showed any association of prostate cancer incidence with egg consumption (case-control studies: odds ratio 1.09, 95% CI 0.86-1.31; cohort studies: relative risk 0.97, 95% CI 0.97-1.07). The results were consistent in subgroup analysis. Furthermore, no association was observed between egg consumption and prostate cancer-specific mortality. Conclusions: Our analyses provided no evidence of a significant influence of egg consumption on prostate cancer incidence and mortality. However, more studies, particularly large prospective studies, are needed.

Section: Discussioncontrasting

confidence: 82%

No Association between Egg Intake and Prostate Cancer Risk: A Meta-analysis

Xie¹,

He²

2012

“…The associations of dietary factors with breast cancer did not vary by menopausal status. Other studies, mostly conducted in Asian populations, have found the same protective effect (Malin et al, 2003;Gaudet et al, 2004;Shannon et al, 2005;Do et al, 2007;Aune et al, 2009;Zhang et al, 2009). A meta-analysis of 23 studies also concluded that vegetable intake reduced breast cancer risk by 20% to 25% (Gaudet et al, 2004).…”

Section: Discussionmentioning

confidence: 89%

Obesity, Diet and Physical Inactivity and Risk of Breast Cancer in Thai Women

Sangrajrang¹,

Chaiwerawattana²,

Ploysawang³

et al. 2013

To evaluate the relationship between obesity, diet, physical activity and breast cancer in Thai women, we conducted a case control study with 1,130 cases and 1,142 controls. Informed consent was obtained from all participants and a structured questionnaire was performed by trained interviewers to collect information on demographic and anthropometric data, reproductive and medical history, residential history, physical activity and occupation as well as dietary habits. A significant positive association with an increased risk of breast cancer was observed in women body mass index (

“…Breast cancer, the most frequent malignancies among women is the leading cause of cancer related death, resulting from the metastatic development of primary stage of cell tumors (Jemal et al, 2006). Application of plants in treatment of different diseases including cancers is inevitable and it seems to be the basis for modern medical science, as they are considered to be great sources of new drugs (Jones et al, 2006;Kim, 2008;Aune et al, 2009;Hasan et al, 2011;Woo and Kim, 2011).…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative Activity of Marrubium persicum Extract in the MCF-7 Human Breast Cancer Cell Line

Hamedeyazdan¹,

Fathiazad²,

Sharifi³

et al. 2012

Aim: Developing antitumor drugs from natural products is receiving increasing interest worldwide due to limitations and side effects of therapy strategies for the second leading cause of disease related mortality, cancer. Methods: The antiproliferative activity of a methanolic extract from the aerial parts of Marrubium persicum extract was assessed with the MCF-7 breast cancer cell line using the MTT test for cell viability and cytotoxicity indices. In addition, antioxidant properties of the extract were evaluated by measuring its ability to scavenge free DPPH radicals. Moreover, the total phenolic and flavonoid content of the extract was determined based on Folin-Ciocalteu and colorimetric aluminum chloride methods. Results: The findings of the study for the antiproliferative activity of the methanolic extract of M. persicum showed that growth of MCF-7 cells was inhibited by the extract in a dose and time dependent manner, where a gradual increase of cytotoxicity effect has been achieved setting out on 200 µg/mL concentration of the plant extract. The antioxidant assay revealed that the extract was a strong scavenger of DPPH radicals with an RC 50 value of 52 µg/mL. The total phenolic and flavonoids content of the plant extract was 409.3 mg gallic acid equivalent and 168.9 mg quercetin equivalent per 100g of dry plant material. Conclusion: Overall, M. persicum possesses potential antiproliferative and antioxidant activities on the malignant MCF-7 cell line that could be attributed to the high content of phenolics and flavonoids, and therefore warrants further exploration.