“…Analogously, the mevalonate (MVA) pathway subserves the selenocysteine tRNA in order to participate in the synthesis of GPX4, and isopentenyl pyrophosphate (IPP) and COQ10 are the main products of this process (Warner et al, 2000). Notably, the heat shock protein family also affects GPX4; specifically, HSPA5 attenuates erastin-induced GPX4 evanishment while the chaperone-mediated autophagy on the strength of HSP90 antagonizes that matter, possibly hastened by legumain (Zhu et al, 2017;Wu Z. et al, 2019;Chen et al, 2021). Intriguingly, as the micronutrient, selenium (Se) and selenoprotein are integral in several metabolic and endocrine diseases, such as thyroid disease and diabetes, and raising their level has been relevant to insulin-induced, hydrogen peroxide (H2O2)-dependent signaling impairment, resulting in insulin resistance and hyperglycemia (Wang et al, 2016;Kim et al, 2019;Schomburg, 2020).…”