Legionnaires Disease with Bacteremic Coinfection

Tan, Michael J.; Tan, James S.; File, Thomas M.

doi:10.1086/341771

Cited by 38 publications

(22 citation statements)

References 29 publications

(34 reference statements)

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“…We identified 10 patients with potentially false-positive results using PLY-ELISA. The observed positive result was probably associated with mixed infections (24,29,30). Two findings that strongly support this hypothesis are that M. pneumoniae, C. pneumoniae, and L. pneumophila lysates produced negative results in PLY-ELISA, whereas the Binax Now S. pneumoniae test was positive in three out of seven of the pneumonia cases diagnosed as nonpneumococcal pneumonia.…”

Section: Discussionmentioning

confidence: 62%

Performance of a Pneumolysin Enzyme-Linked Immunosorbent Assay for Diagnosis of Pneumococcal Infections

García-Suárez¹,

Cima-Cabal²,

Villaverde³

et al. 2007

J Clin Microbiol

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A pneumolysin-specific enzyme-linked immunosorbent assay (PLY-ELISA) for the detection of pneumolysin in urine was developed and evaluated in comparison with the commercially available Binax Now Streptococcus pneumoniae test (Binax, Portland, ME) for the diagnosis of pneumococcal infections. Assay sensitivity was evaluated using urine from 108 patients with culture-confirmed pneumococcal infections. In adults, the sensitivity and specificity of the PLY-ELISA were 56.6% and 92.2%, respectively. In children with nasopharyngeal pneumococcal carriage, PLY-ELISA and Binax Now S. pneumoniae test sensitivities were 62.5% and 87.5%, respectively, while specificities were 94.4% and 27.8%, respectively. In children with nonnasopharyngeal pneumococcal carriage, PLY-ELISA and Binax Now S. pneumoniae test sensitivities were 68.7% and 93.7%, respectively, and test specificities were 94.1% and 41.2%, respectively. The persistence of pneumolysin in urine of pneumococcal pneumonia patients decreased significantly after 4 to 6 days of treatment. Our data suggest that combining the high specificity of the PLY-ELISA with the high sensitivity of the Binax Now S. pneumoniae test would enable pneumococcal infections to be accurately diagnosed in children.

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Section: Discussionmentioning

confidence: 62%

Performance of a Pneumolysin Enzyme-Linked Immunosorbent Assay for Diagnosis of Pneumococcal Infections

García-Suárez¹,

Cima-Cabal²,

Villaverde³

et al. 2007

J Clin Microbiol

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“…Unfortunately, no more sample material was left, so further analysis was not possible. We cannot exclude a possible double infection with both bacteria, which has been observed earlier (Dickgieβer et al, 1985;Tan et al, 2002). However, it might also be a false positive reaction in the ImmuView® test.…”

Section: Resultsmentioning

confidence: 78%

Evaluation of a new lateral flow test for detection of Streptococcus pneumoniae and Legionella pneumophila urinary antigen

Jørgensen

Uldum

Sørensen³

et al. 2015

Journal of Microbiological Methods

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“…The retrospective analysis of these 54 case patients found an in-hospital mortality rate of 25.9%. There had some reports describing such a high mortality rate among HIV patients with active TB and specific bacteria like L. pneumophila and S. pneumoniae infections [30,31]. In addition, hospital-acquired gram-negative bacterial pneumonia has also been regarded as a poor prognostic factor for patients with TB [32].…”

Section: Discussionmentioning

confidence: 99%

Characteristics and Outcome of Patients With Dual Pulmonary Tuberculosis and Non-mycobacterial Respiratory Infections

et al. 2011

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BackgroundMixed tuberculosis (TB) and bacterial respiratory infections are usually seen in areas where there is an HIV epidemic. However, there have been no previous reports regarding TB patients with concomitant bacterial respiratory infections in a non-HIV prevalent region. This study was to evaluate the clinical characteristics and outcomes of patients with dual TB and bacterial respiratory infections in Hualien, Taiwan.MethodsA retrospective cohort study was conducted in a community teaching hospital in Hualien from 2000 to 2007. Those who fulfilled the criteria for active pulmonary tuberculosis (PTB) were included and divided into subjects with concomitant bacterial infections and controls. Their basic data, clinical presentations and in-hospital outcomes were reviewed and analyzed.ResultsDuring 2000 - 2007, a total of 182 patients were diagnosed as having PTB. Of them, 54 (29.7%) had dual infections. Comorbidities were common in these patients. Older age and lower socioeconomic status were present in subjects than in controls. In terms of disease characteristics, symptoms of cough and sputum production, laboratory findings of leukocytosis with left shift, thrombocytopenia, renal insufficiency and lower serum albumin level, as well as radiographic patterns of multi-lobar infiltrates and alveolar consolidations prevailed amongst subjects (P < 0.05). Delayed diagnosis in PTB and increased rates of in-hospital morbidity and mortality associated with polymicrobial infections were noted in subjects with dual infections.ConclusionsIn a non-HIV prevalent area, patients of older age, lacking access to good health care, and suffering from malnutrition were predisposed to dual infections and had poor prognosis and outcomes.KeywordsPulmonary tuberculosis; Dual nontuberculous bacterial respiratory infections

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Legionnaires Disease with Bacteremic Coinfection

Cited by 38 publications

References 29 publications

Performance of a Pneumolysin Enzyme-Linked Immunosorbent Assay for Diagnosis of Pneumococcal Infections

Performance of a Pneumolysin Enzyme-Linked Immunosorbent Assay for Diagnosis of Pneumococcal Infections

Evaluation of a new lateral flow test for detection of Streptococcus pneumoniae and Legionella pneumophila urinary antigen

Characteristics and Outcome of Patients With Dual Pulmonary Tuberculosis and Non-mycobacterial Respiratory Infections

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