Legionella pneumonia caused by Legionella pneumophila serogroup 2: second case report in Japan

Furugen, Makoto; Koide, Michio; Baba, Motoo; Teruya, Hiromitsu; Naha, Yui; Tamayose, Maki; Akamine, Morikazu; Uchihara, Teruhito; Atsumi, Eriko; Haranaga, Shusaku; Yara, Satomi; Higa, Futoshi; Tateyama, Masao; Fujita, Jiro

doi:10.1007/s10156-008-0594-3

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…L. pneumophila SG 1 to 10, 12, 13, and 15 have always been isolated from water distribution systems worldwide more frequently than the other serogroups [ 29 , 30 , 31 ]. Although environmental strains (SG 2–15) account for only 16 to 20% of legionellosis cases [ 32 ], there is evidence that patients with L. pneumophila of SG 2 to 15 show typical symptoms of Legionella pneumonia, but Legionella urinary antigen tests (UATs), which are rapid tools for early diagnosis of legionellosis, are negative because UATs detect only SG 1 [ 33 , 34 , 35 ]. From a public health perspective, this is noteworthy because there is an association between delayed laboratory diagnosis, therapy, and prognosis.…”

Section: Introductionmentioning

confidence: 99%

Innovative Antibiofilm Smart Surface against Legionella for Water Systems

Filice

Sciuto

Faro³

et al. 2022

Microorganisms

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Legionella pneumophila contamination of water systems is a crucial issue for public health. The pathogen is able to persist in water as free-living planktonic bacteria or to grow within biofilms that adhere to and clog filters and pipes in a water system, reducing its lifespan and, in the case of hospital buildings, increasing the risk of nosocomial infections. The implementation of water management is considered to be the main prevention measure and can be achieved from the optimization of water system architecture, notably introducing new materials and strategies to contrast Legionella biofilm proliferation and so prolong the water system functionality. In this research, we propose a new smart surface against L. pneumophila biofilm formation. This is based on an innovative type of coating consisting of a sulfonated pentablock copolymer (s-PBC, commercially named Nexar™) deposited on top of a polypropylene (PP) coupon in a sandwich filter model. The covering of PP with s-PBC results in a more hydrophilic, acid, and negatively charged surface that induces microbial physiological inhibition thereby preventing adhesion and/or proliferation attempts of L. pneumophila prior to the biofilm formation. The antibiofilm property has been investigated by a Zone of Inhibition test and an in vitro biofilm formation analysis. Filtration tests have been performed as representative of possible applications for s-PBC coating. Results are reported and discussed.

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Section: Introductionmentioning

confidence: 99%

Innovative Antibiofilm Smart Surface against Legionella for Water Systems

Filice

Sciuto

Faro³

et al. 2022

Microorganisms

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“…In earlier studies, LP due to non-L. pneumophila serogroup 1 could be a mild to moderate pneumonia [14,15], not only a severe pneumonia admitted to intensive care unit [16][17][18][19][20]. Indeed, we reported a case of LP due to L. pneumophila serogroup 9 in which initial treatment with single-dose oral azithromycin appeared useful, although oral levofloxacin was administered subsequently [15].…”

Section: Legionella Pneumonia Due To Non-legionella Pneumophila Serogmentioning

confidence: 98%

Legionella Pneumonia Due to Non-Legionella pneumophila Serogroup 1

Ito¹,

Ishida²

2020

Hospital Acquired Infection and Legionnaires' Disease

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Legionella pneumophila is one of the important pathogens in communityacquired (CAP) and hospital-acquired pneumonia that can cause severe pneumonia. Early diagnosis and treatment of Legionella pneumonia (LP) are essential because inappropriate therapy for Legionella pneumonia has been reported to worsen the prognosis. The most frequently identified causative pathogen of Legionella pneumonia is Legionella pneumophila serogroup 1. Legionella pneumonia due to non-Legionella pneumophila serogroup 1 is seen in 20% of cases. In diagnosing Legionella pneumonia caused by non-Legionella pneumophila serogroup 1, the urinary antigen test is usually negative; therefore, we need to suspect Legionella pneumonia by clinical information such as symptoms, vital signs, laboratory findings, and radiological findings. Based on our previous report, Legionella pneumonia due to non-Legionella pneumophila serogroup 1 was a mild to severe pneumonia. In addition, in about half of the patients, we could not suspect Legionella pneumonia using a six-point scoring system, which is one of the diagnostic scoring systems. Recently, a new urinary antigen test kit that could theoretically diagnose Legionella pneumonia due to non-Legionella pneumophila serogroup 1 was released in Japan. This can help in early diagnosis of Legionella pneumonia, including the one caused by non-Legionella pneumophila serogroup 1.

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“…Serogroups 2 to 15 account for 16 to 20% of Legionella pneumonia cases [7]. Patients with L. pneumophila of serogroups 2 to 15 showed typical symptoms of Legionella pneumonia, although Legionella urinary antigen detection tests were negative [8][9][10]. In addition, specific differences in the virulence of different serogroups were observed; for instance, Buse et al showed a significant difference in the mobility of L. pneumophila between serogroups [11].…”

Section: Introductionmentioning

confidence: 99%

Legionella pneumophila—Virulence Factors and the Possibility of Infection in Dental Practice

et al. 2022

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Legionella pneumophila is defined as a bacterium that can cause severe pneumonia. It is found in the natural environment and in water, and is often found in water tanks. It can be an integral part of biofilms in nature, and the protozoa in which it can live provide it with food and protect it from harmful influences; therefore, it has the ability to move into a sustainable but uncultured state (VBNC). L. pneumophila has been shown to cause infections in dental practices. The most common transmission route is aerosol generated in dental office water systems, which can negatively affect patients and healthcare professionals. The most common way of becoming infected with L. pneumophila in a dental office is through water from dental instruments, and the dental unit. In addition to these bacteria, patients and the dental team may be exposed to other harmful bacteria and viruses. Therefore, it is vital that the dental team regularly maintains and decontaminates the dental unit, and sterilizes all accessories that come with it. In addition, regular water control in dental offices is necessary.

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Legionella pneumonia caused by Legionella pneumophila serogroup 2: second case report in Japan

Cited by 7 publications

References 15 publications

Innovative Antibiofilm Smart Surface against Legionella for Water Systems

Innovative Antibiofilm Smart Surface against Legionella for Water Systems

Legionella Pneumonia Due to Non-Legionella pneumophila Serogroup 1

Legionella pneumophila—Virulence Factors and the Possibility of Infection in Dental Practice

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