Legg-Calvé-Perthes Disease

Shapiro, Frederic

doi:10.1007/978-3-030-02021-7_2

Cited by 3 publications

(2 citation statements)

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“…For model generation, the teres ligament of the femoral head of 8-week-old rabbits was disrupted, which disrupted the blood flow and resulted in the development of Perthes disease. As depicted in Figure 1, the morphology of the disrupted femoral head exhibited a loss of spherical structure, pale coloration, thickened cartilage layer, and poor gloss, which are commonly observed in children with Perthes disease (Catterall et al, 1982;Doria et al, 2008;Memiş et al, 2018;Shapiro, 2019). X-ray visualization of the femoral heads of the rabbit model revealed a heterogeneous bone density, localized collapse, and loss of spherical structure, which are also observed in children with Perthes disease (Madan et al, 2003;Rich and Schoenecker, 2013;Cheng et al, 2014).…”

Section: Discussionmentioning

confidence: 97%

Construction of ceRNA network based on RNA-seq for identifying prognostic lncRNA biomarkers in Perthes disease

Zhang

et al. 2023

Front. Genet.

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Introduction: Legg-Calvé-Perthes disease or Perthes disease is a condition that occurs in children aged 2 to 15 years, and is characterized by osteonecrosis of the femoral head, which results in physical limitations. Despite ongoing research, the pathogenesis and molecular mechanisms underlying the development of Perthes disease remain unclear. In order to obtain further insights, the expression patterns of long non-coding RNAs (lncRNAs), miRNAs, and mRNAs in a rabbit model of Perthes disease were analyzed in this study by transcriptome sequencing.Methods and results: The results of RNA-seq analyses revealed that 77 lncRNAs, 239 miRNAs, and 1027 mRNAs were differentially expressed in the rabbit model. This finding suggested that multiple genetic pathways are involved in the development of Perthes disease. A weighted gene co-expression network analysis (WGCNA) network was subsequently constructed using the differentially expressed mRNAs (DEmRNAs), and network analysis revealed that the genes associated with angiogenesis and platelet activation were downregulated, which was consistent with the findings of Perthes disease. A competing endogenous RNA (ceRNA) network was additionally constructed using 29 differentially expressed lncRNAs (including HIF3A and LOC103350994), 28 differentially expressed miRNAs (including ocu-miR-574-5p and ocu-miR-324-3p), and 76 DEmRNAs (including ALOX12 and PTGER2).Disscusion: The results obtained herein provide novel perspectives regarding the pathogenesis and molecular mechanisms underlying the development of Perthes disease. The findings of this study can pave the way for the development of effective therapeutic strategies for Perthes disease in future.

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Section: Discussionmentioning

confidence: 97%

Construction of ceRNA network based on RNA-seq for identifying prognostic lncRNA biomarkers in Perthes disease

Zhang

et al. 2023

Front. Genet.

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“…Основною метою занять ФТ є навчання пацієнтів користуватися милицями для ходьби. Для досягнення цієї мети використовують загальнорозвиваючі та дихальні вправи, а також активні динамічні вправи для здорової кінцівки та верхніх кінцівок [13].…”

Section: український журнал лабораторної медицини том 1 №1 2024unclassified

Features of Children's Physical Therapy With Legg-Calve-Pertes Disease

Gavronska,

Korytko

2024

ujlm

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Introduction. The article analyzes modern domestic and foreign publications related to the study of the effectiveness of physical therapy (PT) in Legg-Calve-Perthes disease (or juvenile osteochondrosis of the femoral head). Since today there is no certainty about the superiority of different FT agents in the treatment and rehabilitation of patients with Legg-Calve-Perthes disease of LKP), there is no unanimous opinion regarding the choice of the optimal time for the use of FT agents during the development of the disease, therefore, a review of rehabilitation programs with the features of the use of FT is relevant children with juvenile osteochondrosis of the femoral head. The aim of the study - study of physical therapy features in children with Legg-Calve-Perthes disease with analysis of existing physical rehabilitation programs. Conclusions. Legg-Calve-Perthes disease is characterized by unilateral or bilateral necrosis of the femoral head, which affects the range of motion of the hip. Despite the low incidence, LCP is a serious global health problem, as it affects a significant proportion of children under 15 years of age and is characterized by lameness, pain, and limitation of hip mobility. The causes of LKP disease are unknown. This disease is believed to be multifactorial, caused by a combination of environmental, metabolic, and genetic factors. The pathogenesis of LKP disease is complex, therefore, taking into account the multifactorial etiology, treatment and recovery, the prognosis of the disease is determined according to the characteristics of each patient, such as age, sex, type and size of the affected part of the femur. The analysis of the scientific and methodical literature indicated the need to observe the staged application of FT in the rehabilitation of this disease. The result of treatment and rehabilitation of patients with LKP depends to a large extent on the child's age, weight, gender, size of the femoral head necrososis, and the timeliness of medical and rehabilitation assistance. At the same time, the effectiveness and the choice of the optimal time for the use of FT agents in the course of the development of the disease of LCP have not been fully clarified.

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Legg–Calvé–Perthes disease overview

Rodríguez-Olivas

Hernández-Zamora

Maldonado

2022

Orphanet J Rare Dis

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Background Legg–Calvé–Perthes Disease (LCPD) is a necrosis of the femoral head which affects the range of motion of the hips. Its incidence is variable, ranging from 0.4/100,000 to 29.0/ 100,000 children. Although LCPD was first described in the beginning of the past century, limited is known about its etiology. Our objective is to describe the main areas of interest in Legg–Calve–Perthes disease. Methods A review of the literature regarding LCPD etiology was performed, considering the following inclusion criteria: Studies reporting clinical or preclinical results. The research group carried out a filtered search on the PubMed and Science Direct databases. To maximize the suitability of the search results, we combined the terms ‘‘Perthes disease” OR “LCPD” OR “children avascular femoral head necrosis” with “diagnostic” OR “treatment” OR “etiology” as either key words or MeSH terms. Results In this article been described some areas of interest in LCPD, we include topics such as: history, incidence, pathogenesis, diagnosis, treatment and possible etiology, since LCPD has an unknown etiology. Conclusions This review suggests that LCPD has a multifactorial etiology where environmental, metabolic and genetic agents could be involved.

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Legg-Calvé-Perthes Disease

Cited by 3 publications

References 278 publications

Construction of ceRNA network based on RNA-seq for identifying prognostic lncRNA biomarkers in Perthes disease

Construction of ceRNA network based on RNA-seq for identifying prognostic lncRNA biomarkers in Perthes disease

Features of Children's Physical Therapy With Legg-Calve-Pertes Disease

Legg–Calvé–Perthes disease overview

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