Background: Induced abortion is one of the safest procedures for unwanted pregnancies in medical practice. Vacuum aspiration is the preferred method for uterine evacuation before 12 weeks of pregnancy. Objectives: To study the efficacy of manual vacuum aspiration (MVA) in o8 wk versus 8-12 wk of pregnancy. Materials and Methods: A randomized comparative prospective study was performed at the Department of Obstetrics and Gynaecology, P D U Medical College, Rajkot, over a period of January 2012 to June 2013. Totally, 100 subjects were enrolled in the study, which were further divided into two groups (o8 wk and 8-12 wk of pregnancy, 50 in each). MVA was performed in both the groups, and comparison was done in view to evaluate completeness of procedure, requirement of add-on procedure, and complications. Results: Of 50 subjects in each group, perforation was found in two cases in group A and one case in group B. Requirement of oxytocics noted in only one case in group B, whereas incomplete abortion noted in two cases in group A and three in group B. All complications were found statistically insignificant (P = 1) between both the groups. Conclusion: This study focused on the efficacy of MVA in higher weeks of gestations, which was equal in both the groups. Thus, MVA is a safe and an acceptable procedure up to 12 wk of pregnancy.