Legacy and currently used pesticides in the atmospheric environment of Lake Victoria, East Africa

Arinaitwe, Kenneth; Kiremire, Bernard T.; Muir, Derek C. G.; Fellin, Phil; Li, Henrik; Teixeira, Carlos; Mubiru, Drake N.

doi:10.1016/j.scitotenv.2015.10.146

Cited by 45 publications

(37 citation statements)

References 30 publications

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“…Chlorothalonil (2,4,5,6-tetrachloroisophthalonitrile) is one of the most commonly used non-absorbable broad-spectrum fungicides, which is widely used in fruits, vegetables, grains and other crops[1]. Due to the widespread use of chlorothalonil, it is frequently reported that chlorothalonil remains in the atmosphere, water, soil and other environmental media[2-3]. According to the relevant toxicology experiments, chlorothalonil has accumulation effect in animals.…”

Section: Instructionsmentioning

confidence: 99%

Development of the yeast Saccharomyces cerevisiae as a biosensor for the toxicity detection of toxic substances

Gong

Yang

et al. 2020

Preprint

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A whole-cell biosensor developed with yeast Saccharomyces cerevisia to detect the toxicity of chlorothalonil has been developed. This biosensor relied on the inhibition effect for metabolism by toxicants to provide detection and the degree of toxicity to yeast cells. In order to further improve the toxic sensitivity of yeast cells biosensor, the effect of the action time, the initial pH value of the medium and the temperature on inhibiting cell growth were investigated. 10Response surface regression analysis was conducted to obtain optimal culture conditions. Th effects of treated yeast morphology, ROS, DNA, caspase 3 activity were analyzed. This optimized yeast as a biosensor was used to detect chlorothalonil and heavy metals. The results are as follows: at optimal culture conditions, EC50 values of chlorothalonil to yeast biosensor determined at incubation time 4 h increased from 0.25 µg·mL -1 in the control to 0.006 µg·mL -1 , which increased 15 by 41.67 times. Compared with the control yeast cells, the morphology of optimized yeast cells were more transparent, with significantly increased intracellular vesicle rate and cell membrane permeability, intracelluar ROS increased siginificantly, DNA bands extracted was ladder, and caspase 3 activity was stimulated. The yeast biosensor had a high sensitivity to heavy metals. After analysis, many treated cells were apoptosis which was the main reason for the increasing 20 sensitivity to detect harmful substances. It was found that the method provides a new idea for the detection of harmful substances in the environment.

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Section: Instructionsmentioning

confidence: 99%

Development of the yeast Saccharomyces cerevisiae as a biosensor for the toxicity detection of toxic substances

Gong

Yang

et al. 2020

Preprint

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“…Carrying this concept to Kenya where aflatoxins produced by Aspergillus on maize cause death and morbidity following consumption, a pilot study of school children showed that daily intake of the probiotic yogurt can reduce toxin uptake (Nduti et al 2016). Given the use of pesticides, the high amounts of heavy metals in lakes and the problem of aflatoxins in food in eastern Africa (Ochieng et al 2007;Kilonzo et al 2014;Kang et al 2015;Okonya and Kroschel 2015;Arinaitwe et al 2016), any method of lowering risk of toxicity must be considered and pursued.…”

Section: Reaching Impoverished Communitiesmentioning

confidence: 99%

The development of probiotics for women’s health

Reid

2017

Can. J. Microbiol.

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Abstract:The idea you could use lactic acid bacteria to treat and prevent recurrence of vaginal infections was ridiculed in the early 1980s. Bacteria were the bad guys to be eradicated by current and emerging antibiotic classes. Thirty years later, probiotic administration of microbes is widespread worldwide, including for vaginal and bladder health in women, and the scientific basis and clinical efficacy data for this and multiple other applications prove the viability of this concept. The development of this approach, the creation of a definition for probiotics, and the expansion to other areas of women's health form the basis of this review.

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“…They are now among the catalog of 'emerging pollutants' (Mai et al, 2013). CUPs are not only identified in the regions where they are applied, such as agricultural and forestry areas (Arinaitwe et al, 2016;Asman et al, 2005;Feng et al, 2016;Yao et al, 2008a), rural and urban areas (Carratala et al, 2017;Coscolla et al, 2017;Estellano et al, 2015), but also in regions far away from their sources, such as the Arctic (Hoferkamp et al, 2010;Morris et al, 2016;Walker and Nidiry, 2002;Zhong et al, 2012a), high mountains (Hageman et al, 2006), the and Indian-Pacific Ocean (Bigot et al, 2016). China produces and consumes the largest amount of CUPs in the world.…”

Section: Introductionmentioning

confidence: 99%

Spatial distribution and seasonal variation of four current-use pesticides (CUPs) in air and surface water of the Bohai Sea, China

Liu

Tang

Zhong

et al. 2018

Science of The Total Environment

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Legacy and currently used pesticides in the atmospheric environment of Lake Victoria, East Africa

Cited by 45 publications

References 30 publications

Development of the yeast Saccharomyces cerevisiae as a biosensor for the toxicity detection of toxic substances

Development of the yeast Saccharomyces cerevisiae as a biosensor for the toxicity detection of toxic substances

The development of probiotics for women’s health

Spatial distribution and seasonal variation of four current-use pesticides (CUPs) in air and surface water of the Bohai Sea, China

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