Leg Ulceration in Sickle Cell Anemia

Serjeant, G. R.

doi:10.1001/archinte.1974.00320160184017

Cited by 82 publications

(43 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The increased risk of ulceration reflects factors local to the circulation around the ankle because almost all ulcers occur at this site and there is no evidence for delayed skin healing at other sites or following surgery. In this context, the distribution of ulcers at the different sites has been of interest, with medial involvement predominating in one study (Sawhney et al, 2002) and left sided involvement in another (Serjeant, 1974) but no site predominated in the CSSCD (Koshy et al, 1989) or the current Jamaican report.…”

Section: Discussionmentioning

confidence: 73%

Venous incompetence, poverty and lactate dehydrogenase in Jamaica are important predictors of leg ulceration in sickle cell anaemia

Cumming¹,

King²,

Fraser³

et al. 2008

Br J Haematol

View full text Add to dashboard Cite

SummaryClinical features and potential risk factors for chronic leg ulceration (duration >6 months) in homozygous sickle cell (SS) disease were examined in 225 subjects in the Jamaican Cohort Study. Potential risk factors included the number of HBA genes, steady state haematology, serum lactate dehydrogenase (LDH), venous incompetence, and socio‐economic status. Chronic ulcers occurred in 53 subjects with the highest risk of ulcer development at 18 years. The prevalence was 29·5% and cumulative incidence 16·7%. Gender or α‐thalassaemia trait did not affect the incidence of leg ulcer. Ulceration was associated with lower haemoglobin, red cell count, fetal haemoglobin, and socio‐economic status and higher reticulocyte count, platelet count, serum LDH and venous incompetence in univariate analyses. Venous incompetence [Hazard Ratio (HR) 3·0–4·0] and socio‐economic status (HR 0·8) were most consistently associated with leg ulceration on multivariate analysis. Regression models incorporating serum LDH suggested this to be a stronger predictor than haematological indices. The prevalence of ulcers at 30% is less than previous estimates in Jamaica, probably reflecting the lack of ascertainment bias in the Cohort Study, and also a real secular decline. In Jamaica, venous incompetence, low socio‐economic status, and high serum LDH were the strongest predictors of chronic ulceration.

show abstract

Section: Discussionmentioning

confidence: 73%

Venous incompetence, poverty and lactate dehydrogenase in Jamaica are important predictors of leg ulceration in sickle cell anaemia

Cumming¹,

King²,

Fraser³

et al. 2008

Br J Haematol

View full text Add to dashboard Cite

show abstract

“…In a recently published study of 457 SCD patients followed for ten years in a French referral center, 5.5% of patients had leg ulcerations [11]. In contrast, Serjeant reported 75% of Jamaican SCD patients older than 30 years had either active or healed ulcers [12]. This wide variability may be partially explained by discrepancies in socioeconomic status between the groups of individuals studied ( Table 1).…”

Section: Prevalencementioning

confidence: 99%

“…Lower socioeconomic status [12] Male gender [10] Prior history of leg ulcers [10] Antithrombin III deficiency [36] SNPs in Klotho, TEK, and several genes in TGF-β/BMP [5]  Copyright © 2013 SciRes.…”

Section: Clinical Features and Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Cutaneous Manifestations of Sickle Cell Disease

Jones¹,

Blinder²,

Anadkat³

2013

OJBD

View full text Add to dashboard Cite

show abstract

“…Chronic leg ulcers are common in patients with sickle cell disease [1][2][3]. The etiological factors are illdefined, but include local trauma, impaired circula tion, increased venous pressure, abnormal blood rhe ology and tissue hypoxia [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Recombinant Human Erythropoietin Induced Rapid Healing of a Chronic Leg Ulcer in a Patient with Sickle Cell Disease

Al-Momen

1991

Acta Haematol

View full text Add to dashboard Cite

A 23-year-old man with severe sickle cell disease and a chronic non-healing left leg ulcer was entered into a study in which he received hydroxyurea (HU) and recombinant human erythropoietin (r-HuEPO) in order to modify the severity of his disease. HU 20 mg/kg/day effectively prevented vaso-occlusive crises and improved hematological parameters, but the chronic leg ulcer and chronic mild bone pains remained. Six months later, r-HuEPO 600–800 IU/kg subcutaneously was added at weekly intervals. This led to a rapid and complete healing of the chronic leg ulcer, further improvement in hematological parameters and relief from chronic pains. We conclude that treatment with r-HuEPO may provide an effective therapy for chronic leg ulcers in patients with sickle cell disease.

show abstract

Leg Ulceration in Sickle Cell Anemia

Cited by 82 publications

References 23 publications

Venous incompetence, poverty and lactate dehydrogenase in Jamaica are important predictors of leg ulceration in sickle cell anaemia

Venous incompetence, poverty and lactate dehydrogenase in Jamaica are important predictors of leg ulceration in sickle cell anaemia

Cutaneous Manifestations of Sickle Cell Disease

Recombinant Human Erythropoietin Induced Rapid Healing of a Chronic Leg Ulcer in a Patient with Sickle Cell Disease

Contact Info

Product

Resources

About