Leg muscle scintigraphy with 99Tcm-MIBI in the assessment of peripheral vascular (arterial) disease

Miles, Kenneth; Barber, Robert W.; Wraight, E. P.; COOPER, M.; APPLETON, D. S.

doi:10.1097/00006231-199213080-00004

Cited by 12 publications

(12 citation statements)

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“…8 MIBI has also been used in extremity perfusion studies. [9][10][11][12] It was shown that distribution of MIBI in the body changes with time; for this reason, early (20 min) and late (2 hr) images were taken in this study. 200-mCi Tc-99m-MIBI (Cardio-SPECT, Isotope, Hungary) was prepared in 0.3 ml saline solution, as indicated.…”

Section: Methodsmentioning

confidence: 99%

Evaluation by Scintigraphy of Hindlimb Ischemia in a Rat Model

Babucçu¹,

Peksoy²,

Hoşnuter³

et al. 2004

J reconstr Microsurg

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The subject of ischemia-reperfusion has commonly been studied in rat hindlimb models. Unfortunately, in these experiments, the ischemia procedures lack standardization. For this reason, the authors evaluated the reliability of rat ischemia models described in the literature using scintigraphy. The study comprised six groups. Each consisted of ten male Wistar rats; five of them underwent methoxy-isobutyl-isonitrile (MIBI) scintigraphy, which is specific for muscle, and the others underwent methylene diphosphanate (MDP) scintigraphy, which is specific for bone. In Group 1, only the iliac artery was ligated; in Group 2, the iliac artery and its branches, except for the superficial epigastric artery, were ligated; in Group 3, the iliac artery and vein were ligated; in Group 4, the iliac artery and all branches, including the superficial epigastric artery, were ligated; in Group 5, in addition to ligation of the iliac artery and its branches, the skin was incised circumferentially around the pelvic girdle; in Group 6, a tourniquet was applied to the limb at the pelvic level. After 2-hr warm ischemia, a radioactive tracer was injected intravenously. In the MIBI group, images were taken at the twentieth minute and second hour after injection, and in the MDP group, at the fifth minute and third hour after injection. The radioactivity in both hind limbs of the animal was measured, and the ratio of the control to the ischemic limb was calculated. In the first five groups, there was no necrosis in the ischemic limb at the end of 2 weeks. The measured radioactivity in the ischemic limb was lower than that of the control limb in all groups. The ratio of activity obtained from the control limb to that of the ischemic limb in the tourniquet group was significantly higher, compared to other groups in both MIBI and MDP evaluations (p < 0.005). Significant ischemia was also seen in the skin incision group (Group 5). A low-flow state was observed in the ischemic limb in Groups 1-4 using both scintigraphic modalities. The tourniquet method (Group 6) provided almost complete limb ischemia, compared to other arterial ligation methods, and it is practical to use for complete ischemia when studying the physiology of replantation or free flaps.

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Section: Methodsmentioning

confidence: 99%

Evaluation by Scintigraphy of Hindlimb Ischemia in a Rat Model

Babucçu¹,

Peksoy²,

Hoşnuter³

et al. 2004

J reconstr Microsurg

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“…33 Planar imaging studies using 99m Tc-sestamibi (MIBI) have demonstrated significant reductions in proximal and distal lower extremity perfusion in asymptomatic patients who presented with early stages of atherosclerosis, 34 and have also revealed impairments in rest and exercise stress perfusion when comparing PVD to control patients. 35,36 Additionally, Miles et al 35 demonstrated that 99m Tc-MIBI possessed a very high sensitivity (91%) and specificity (94%) for diagnosing PVD, and also demonstrated that 99m Tc-MIBI uptake significantly correlated with angiographic and Doppler findings. Because of the limited redistribution associated with 99m Tc-MIBI, there has been recent focus on 99m Tc-MIBI lower extremity imaging in patients already undergoing myocardial perfusion imaging for the purposes of identifying potential lower extremity abnormalities in asymptomatic and symptomatic patients.…”

Section: Radionuclide Imaging Of Skeletal Muscle Perfusion and Blood mentioning

confidence: 99%

Novel Applications of Radionuclide Imaging in Peripheral Vascular Disease

Stacy

Sinusas

2016

Cardiology Clinics

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Peripheral vascular disease (PVD) is a progressive atherosclerotic disease that leads to stenosis or occlusion of blood vessels supplying the lower extremities. Current diagnostic imaging techniques commonly focus on evaluation of anatomy or blood flow at the macrovascular level and do not permit assessment of the underlying pathophysiology associated with disease progression or treatment response. Molecular imaging with radionuclide-based approaches, such as PET and SPECT, can offer novel insight into PVD by providing non-invasive assessment of biological processes such as angiogenesis and atherosclerosis. This review discusses emerging radionuclide-based imaging approaches that have potential clinical applications in the evaluation of PVD progression and treatment.

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“…99m Tc-sestamibi was also used for evaluation of regional blood supply of thigh and calf muscles in early stages of atherosclerosis [59, 60]. A reduced stress and rest perfusion of lower limb muscles could be documented in clinically asymptomatic patients with atherosclerotic changes of lower limb vessels.…”

Section: Clinical Imaging Of Extremity Ischemiamentioning

confidence: 99%

PET/SPECT imaging of hindlimb ischemia: focusing on angiogenesis and blood flow

et al. 2012

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Peripheral artery disease (PAD) is a result of the atherosclerotic narrowing of blood vessels to the extremities, and the subsequent tissue ischemia can lead to the up-regulation of angiogenic growth factors and formation of new vessels as a recovery mechanism. Such formation of new vessels can be evaluated with various non-invasive molecular imaging techniques, where serial images from the same subjects can be obtained to allow the documentation of disease progression and therapeutic response. The most commonly used animal model for preclinical studies of PAD is the murine hindlimb ischemia model, and a number of radiotracers have been investigated for positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging of PAD. In this review article, we summarize the PET/SPECT tracers that have been tested in the murine hindlimb ischemia model as well as those used clinically to assess the extremity blood flow.

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Leg muscle scintigraphy with 99Tcm-MIBI in the assessment of peripheral vascular (arterial) disease

Cited by 12 publications

References 0 publications

Evaluation by Scintigraphy of Hindlimb Ischemia in a Rat Model

Evaluation by Scintigraphy of Hindlimb Ischemia in a Rat Model

Novel Applications of Radionuclide Imaging in Peripheral Vascular Disease

PET/SPECT imaging of hindlimb ischemia: focusing on angiogenesis and blood flow

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