Left ventricular twist is impaired in acromegaly: Insights from the three‐dimensional speckle tracking echocardiographic MAGYAR‐Path Study

Kormányos, Árpád; Domsik, Péter; Kalapos, Anita; Orosz, Andrea; Lengyel, Csaba; Valkusz, Zsuzsanna; Trencsányi, Attila; Forster, Tamás; Nemes, Attila

doi:10.1002/jcu.22529

Cited by 21 publications

(24 citation statements)

References 33 publications

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“…This phenomenon was first reported in noncompaction cardiomyopathy (NCCM) . Our group has reported this phenomenon in a number of pathological states such as cardiac amyloidosis, acromegaly and congenital heart diseases . It is not known whether this is a sign of a yet subclinical pathology or undiagnosed disease; however, to the best of our knowledge, this phenomenon has not been previously reported in the healthy population.…”

Section: Discussionmentioning

confidence: 83%

Normal values of left ventricular rotational parameters in healthy adults—Insights from the three‐dimensional speckle tracking echocardiographic MAGYAR‐Healthy Study

et al. 2019

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Introduction Left ventricular (LV) rotation and twist are essential parts of LV function. Three‐dimensional speckle tracking echocardiography (3DSTE) is a relatively new method and is useful for the quantification of LV wall deformation and rotational parameters. The aim of the present study was to examine LV rotation and twist differences between different age‐groups and genders in a healthy population. Methods The present study is comprised of 297 healthy adults; 120 adults have been excluded due to inferior image quality. The population was further divided into 4 subgroups based on age decades. Results Only the LV twist of all patients (13.5 ± 3.7 degree vs 15.6 ± 4.9 degree, P = 0.02) and the LV twist of females (13.0 ± 3.6 degree vs 15.5 ± 5.6 degree, P = 0.03) differed significantly between the age‐group of 18–29 years and 50+ years. LV basal and apical rotation were not significantly different between the age‐groups; however, they tendentiously increased with aging. No significant differences could be demonstrated regarding LV rotational and twist parameters between genders in any group. A phenomenon called LV rigid body rotation (LV‐RBR)—where the base and apex of the LV rotate in the same direction—was present in 10 cases. Conclusions Three‐dimensional speckle tracking echocardiography seems to be a reasonably viable tool for the quantification of LV rotation and twist. Both LV basal and apical rotation and LV twist increase with aging, regardless of gender. LV‐RBR is also present in the normal population.

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Section: Discussionmentioning

confidence: 83%

Normal values of left ventricular rotational parameters in healthy adults—Insights from the three‐dimensional speckle tracking echocardiographic MAGYAR‐Healthy Study

et al. 2019

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“…This towel‐wringing‐like movement is responsible for ~40% of systolic pumping function 20 . LV twist is impaired is several pathologic conditions 22 and its absence (LV‐RBR) can be detected in large percent of patients with noncompaction cardiomyopathy 16 or cardiac amyloidosis 23 …”

Section: Discussionmentioning

confidence: 99%

The impact of lower body compression garment on left ventricular rotational mechanics in patients with lipedema—Insights from the three‐dimensional speckle tracking echocardiographic MAGYAR‐Path Study

et al. 2020

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Summary Lipedema is a lymphedema‐masquerading symmetrical, bilateral and disproportional obesity. Its conservative maintenance treatment comprises the use of flat‐knitted compression pantyhoses. Lipedema is known to be associated with left ventricular morphological and functional alterations. The present study aimed to assess the effects of graduated compression stockings on left ventricular (LV) rotational mechanics measured by three‐dimensional speckle‐tracking echocardiography (3DSTE) in lipedema patients. The present study comprised twenty lipedema patients (mean age: 45.8 ± 11.0 years, all females) undergoing 3DSTE who were also compared to 51 age‐ and gender‐matched healthy controls (mean age: 39.8 ± 14.1 years, all females). 3DSTE analysis was performed at rest, and subsequent to 1 hour application of compression class 2 made‐to‐measure flat‐knitted pantyhose. Six lipedema patients showed significant LV rotational abnormalities. Of the remaining fourteen lipedema patients LV basal rotation rotation showed significant reduction, while LV apical rotation showed significant increase with unchanged LV twist after a 60‐minute use of compression garment. Significant changes in LV rotational mechanics could be detected among 14 women with lipedema after the use of compression garment however six probands have special LV rotational abnormalities at baseline and/or after compression.

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“…12 3DSTE study, 10% of healthy subjects showed LV-RBR, which ratio seems to be in the similar range as in HES patients (2 out of 12). 15 The most experience is with noncompaction cardiomyopathy, 16 where ratio of LV-RBR is between 50% and 100%, but higher ratio could be demonstrated in cardiac amyloidosis (60%), 17 dilated/nonischemic (50%) 18 and hypertensive cardiomyopathies (32%), 19 and acromegaly (20%), 20 as well.…”

Section: Discussionmentioning

confidence: 99%

Left ventricular rotational mechanics in hypereosinophilic syndrome—Analysis from the three‐dimensional speckle‐tracking echocardiographic MAGYAR‐Path Study

et al. 2019

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Introduction: Hypereosinophilic syndrome (HES) is a very heterogeneous group ofdisorders with varied etiologies characterized by peripheral eosinophilia and eosinophilic tissue/end-organ damage. Three-dimensional speckle-tracking echocardiography (3DSTE) was used for assessment of left ventricular (LV) rotational mechanics in HES patients. Methods:The study comprised 13 HES patients, from which one patient was excluded due to insufficient image quality. The remaining patient population consisted of 12 HES cases (mean age: 59.7 ± 13.7 years, eight males). The control group consisted of 36 healthy volunteers (mean age: 52.9 ± 8.3 years, 23 males). 3DSTE was used for the evaluation of LV rotational abnormalities.Results: Both LV apical rotation (4.86 ± 1.92 degree vs 10.07 ± 3.92 degree, P < .0001) and LV twist (8.52 ± 2.79 degree vs 14.41 ± 4.26 degree, P < .0001) showed significant deteriorations in most of HES patients. Time-to-peak LV apical rotation (380 ± 115 ms vs 344 ± 69 ms, P = .56), LV basal rotation (335 ± 148 ms vs 337 ± 111 ms, P = .89), and LV twist (348 ± 91 ms vs 320 ± 60 ms, P = .64) were not significantly different between HES patients and controls. No correlations could be detected between absolute eosinophil count and eosinophil ratio and apical LV rotation (r = 0.12, P = .51 and r = 0.23, P = .45, respectively) and LV twist (r = 0.24, P = .39 and r = 0.31, P = .34, respectively). In two subjects, the absence of LV twist called LV "rigid body rotation" (RBR) was detected. Conclusions: Reduced LV apical rotation and twist could be demonstrated in HES.LV-RBR could be detected in some HES patients. K E Y W O R D S echocardiography, hypereosinophilic syndrome, left ventricular, rotation, speckle-tracking, three-dimensional, twist | 2065 NEMES Et al.

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Left ventricular twist is impaired in acromegaly: Insights from the three‐dimensional speckle tracking echocardiographic MAGYAR‐Path Study

Abstract: Acromegaly is associated with impaired LV rotation and twist as assessed by 3-dimensional speckle tracking echocardiography. LV-RBR is a frequent phenomenon in acromegaly.

Cited by 21 publications

References 33 publications

Normal values of left ventricular rotational parameters in healthy adults—Insights from the three‐dimensional speckle tracking echocardiographic MAGYAR‐Healthy Study

Normal values of left ventricular rotational parameters in healthy adults—Insights from the three‐dimensional speckle tracking echocardiographic MAGYAR‐Healthy Study

The impact of lower body compression garment on left ventricular rotational mechanics in patients with lipedema—Insights from the three‐dimensional speckle tracking echocardiographic MAGYAR‐Path Study

Left ventricular rotational mechanics in hypereosinophilic syndrome—Analysis from the three‐dimensional speckle‐tracking echocardiographic MAGYAR‐Path Study

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