Left ventricular transmural systolic function by high-sensitivity velocity measurement “phased-tracking method” across the septum in doxorubicin cardiomyopathy

Koiwa, Yoshiro; Kanai, Hiroshi; Hasegawa, Hideyuki; Saitoh, Yoshiko; Shirato, Kunio

doi:10.1016/s0301-5629(02)00644-0

Cited by 12 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The change in thickness, ÁĥðtÞ, between two different depths (LIB and MAB) was obtained from the difference between the displacementsx a andx b at the LIB and MAB: wherev a andv b are the velocities at the LIB and MAB, respectively. The phased-tracking method has been used in various applications, e.g., measurements of the motion and deformation of the arterial and heart walls [17][18][19] for evaluating the viscoelastic properties and the myocardial function, [20][21][22][23] and measuring viscoelastic properties with acoustic radiation force. 24,25) 2.2 Correction of change in propagation time delay of pulse wave PWV changes with some factors such as the elasticity and diameter of the artery, and the thickness of the arterial wall.…”

Section: Measurement Of Stress-strain Relationshipmentioning

confidence: 99%

Correction of change in propagation time delay of pulse wave during flow-mediated dilation in ultrasonic measurement of arterial wall viscoelasticity

Sato

Hasegawa

Kanai

2014

Jpn. J. Appl. Phys.

Self Cite

View full text Add to dashboard Cite

It is considered that the endothelial dysfunction occurs in the initial step of atherosclerosis. Although assessments of the endothelial function and viscoelastic properties of the intima-media region are important for the diagnosis of early-stage atherosclerosis, regional viscoelasticity has not yet been measured in vivo. Our group has developed an ultrasonic method for measuring the transient change in viscoelasticity during flow-mediated dilation (FMD). However, in this method, the stress (blood pressure) and strain of the intima-media region of the radial artery are measured in different arms, and the change in pulse wave velocity (PWV) due to FMD has not yet been considered. In the present study, we measured blood pressure waveforms using two pressure sensors, which were placed along the same radial artery for the ultrasonic measurement, to obtain blood pressure waveforms and estimate the PWV between the two sensors. Using the measured PWV, the pulse wave propagation time from the pressure sensor to the position of the ultrasound probe was corrected, and viscoelasticity was estimated from the corrected stress-strain relationship. In the basic experiment, we applied the proposed method to a silicone tube phantom and evaluated the accuracy of the estimation of viscoelasticity by comparing the ultrasonic measurement to the results of the tensile test. In the in vivo measurements, the change in the propagation time delay of the pulse wave was also corrected using the two pressure sensors and the stress-strain relationship of the radial arterial wall was then obtained to estimate viscoelasticity. Furthermore, a decrease in elasticity owing to FMD after recirculation was clearly observed, and the unstable temporal variation in viscosity was significantly reduced. These results demonstrated the improvement in the accuracy of the measurement of viscoelasticity by the proposed method.

show abstract

Section: Measurement Of Stress-strain Relationshipmentioning

confidence: 99%

Correction of change in propagation time delay of pulse wave during flow-mediated dilation in ultrasonic measurement of arterial wall viscoelasticity

Sato

Hasegawa

Kanai

2014

Jpn. J. Appl. Phys.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The development of noninvasive, reproducible, easy‐to‐use, sensitive diagnostic techniques would greatly improve the detection of early pathological changes associated with treatment regimens . One such technique is the phased tracking method (PTM) , a high‐resolution Doppler measurement that is useful for detecting cardiac transmural changes , the PTM is measured on minute amplitude on the order of several tens of micrometers up to several hundred Hertz, which has neither been recognized in TDI nor standard M‐mode, B‐mode, 2D‐strain echocardiography. These fine measurement characteristics and the rapid minute amplitude have allowed measurement of the fetal heart and the fetal descending aorta of normal and growth‐restricted fetuses .…”

Section: Introductionmentioning

confidence: 99%

“…The development of noninvasive, reproducible, easy-to-use, sensitive diagnostic techniques would greatly improve the detection of early pathological changes associated with treatment regimens [2,3]. One such technique is the phased tracking method (PTM) [4], a highresolution Doppler measurement that is useful for detecting cardiac transmural changes [5,6], the PTM is measured on minute amplitude on the order of several tens of…”

Section: Introductionmentioning

confidence: 99%

Noninvasive early detection of anthracycline‐induced cardiotoxicity in patients with hematologic malignancies using the phased tracking method

et al. 2016

Self Cite

View full text Add to dashboard Cite

Anthracyclines are among the most effective and widely used anticancer drugs; however, their use is limited by serious cardiotoxicity. Early detection is necessary to prevent the high mortality rate associated with heart failure (HF). We evaluated cardiac function in 142 patients using conventional echocardiography and the phased tracking method (PTM), which was measured using the minute vibration and the rapid motion components, neither of which is recognized in standard M‐mode nor in tissue Doppler imaging. For systolic function comparison, we compared left ventricular ejection fraction (LVEF) in conventional echocardiography with the average velocity of ventricular septum myocytes (Vave) in the PTM. The Vave of 12 healthy volunteers was 1.5 (m/s)/m or more. At baseline of 99 patients, there was a positive correlation between LVEF and Vave in all patients. There were no significant differences in baseline cardiac function between patients with and without HF. There was a negative correlation between the cumulative anthracycline dose and LVEF or Vave among all patients. We determined that Vave 1.5 (m/s)/m was equivalent to LVEF 60%, 1.25 (m/s)/m to 55%, and 1.0 (m/s)/m to 50%. During the follow‐up period, there was a pathological decrease in LVEF (<55%) and Vave (<1.25 m/s/m) in patients with HF; decreases in Vave were detected significantly earlier than those in LVEF (P < 0.001). When Vave declined to 1.5 (m/s)/m or less, careful continuous observation and cardiac examination was required. When Vave further declined to 1.0 (m/s)/m or lower, chemotherapy was postponed or discontinued; thus, serious drug‐induced cardiomyopathy was avoided in patients who did not relapse. The PTM was superior to echocardiography for early, noninvasive detection and intermediate‐term monitoring of left ventricle systolic function associated with anthracycline chemotherapy, among patients with hematologic malignancies. The PTM was an effective laboratory procedure to avoid the progression to serious cardiomyopathy.

show abstract

“…Further, it has been reported to allow highly precise assessments of doxorubicin-induced myocardial dysfunction in adults [11]. Increases in the myocardial thickening rate have also been reported in healthy fetuses, indicating that such increases occur with gestational age [12].…”

Section: Introductionmentioning

confidence: 99%

Assessing Fetal Cardiac Function by Measuring Myocardial Radial Velocity Using the Phased-Tracking Method

Ozawa¹,

Murotsuki²,

Miyashita³

et al. 2015

Fetal Diagn Ther

Self Cite

View full text Add to dashboard Cite

Objective: This study aimed to assess the cardiac function of healthy and pathological fetuses by measuring radial velocity using phased tracking (PT). Based on phase differences, PT allows the displacement of a specified point to be detected with improved spatial and temporal resolution. Methods: PT was used to assess cardiac radial velocity in the basal free wall of the left and right ventricles in 134 healthy fetuses, 10 second-trimester intrauterine growth-restricted (IUGR) fetuses, and 10 recipient twins with twin-to-twin transfusion syndrome (TTTS). Maximum velocities were measured in systole and early diastole. Results: Maximum radial velocity was successfully measured in 126 healthy fetuses (94%) at gestational ages of 16-40 weeks. Systolic and early diastolic maximum velocities increased with gestational age in both ventricles. As compared with controls, IUGR fetuses had significantly lower early diastolic maximum velocities in the right ventricle, and recipient twins with TTTS had significantly lower systolic and early diastolic maximum velocities in both ventricles. Conclusions: PT demonstrated right ventricular diastolic dysfunction in second-trimester IUGR fetuses as well as systolic and diastolic dysfunctions in both ventricles in recipient twins with TTTS. PT could be useful for evaluating fetal cardiac radial function.

show abstract

Left ventricular transmural systolic function by high-sensitivity velocity measurement “phased-tracking method” across the septum in doxorubicin cardiomyopathy

Cited by 12 publications

References 23 publications

Correction of change in propagation time delay of pulse wave during flow-mediated dilation in ultrasonic measurement of arterial wall viscoelasticity

Correction of change in propagation time delay of pulse wave during flow-mediated dilation in ultrasonic measurement of arterial wall viscoelasticity

Noninvasive early detection of anthracycline‐induced cardiotoxicity in patients with hematologic malignancies using the phased tracking method

Assessing Fetal Cardiac Function by Measuring Myocardial Radial Velocity Using the Phased-Tracking Method

Contact Info

Product

Resources

About