Left Ventricular Torsion

Rüssel, Iris K.; Götte, Marco J.W.; Bronzwaer, Jean G.F.; Knaapen, Paul; Paulus, Walter J.; Rossum, Albert C. van

doi:10.1016/j.jcmg.2009.03.001

Cited by 149 publications

(61 citation statements)

References 48 publications

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“…A reduced global longitudinal strain demonstrated a negative prognostic value in different diseases [18,19,20,21,22,23,24,25,26,27,28]; thus, the reduced value of longitudinal deformation in ALCAPA patients could be used to identify the subgroup of patients at higher risk. In agreement with previous studies [12], circumferential deformation was normal in our selected sample of ALCAPA patients.…”

Section: Discussionmentioning

confidence: 99%

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Left Ventricular Mechanics in Patients with Abnormal Origin of the Left Main Coronary Artery from the Pulmonary Trunk Late after Successful Repair

Salvo

Siblini²,

Issa³

et al. 2016

Cardiology

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Objective: Our aim was to evaluate left ventricular (LV) mechanics by using speckle tracking echocardiography (STE) in asymptomatic patients with abnormal origin of the left main coronary artery from the pulmonary trunk (ALCAPA), late after successful repair, in the presence of LV ejection fraction (EF) >50%. Methods: We studied 30 ALCAPA patients (median age 4 years, range 1-25 years, NYHA class I, LVEF >50%) and 16 healthy age- and sex-matched controls (median age 5 years, range 1-25 years). All underwent standard echocardiographic evaluation and STE. Results: LV dimensions and LVEF (63.6 ± 8.2% vs. 64.1 ± 5.1%, p = 0.826) were not different between patients and controls. Diastolic parameters were significantly abnormal in our patients versus controls (E/e' average: 11.9 ± 5.8 vs. 6.6 ± 3.0, p = 0.0014). Global LV longitudinal strain was significantly lower in ALCAPA patients versus controls (-17.6 ± 3.5% vs. -23.4 ± 3.1%, p < 0.0001). LV torsion (9.1 ± 4.9° vs. 11.9 ± 3.3°, p = 0.046) was significantly impaired in ALCAPA patients. Conclusions: After successful repair in asymptomatic ALCAPA patients, despite an LVEF >50%, diastolic function, LV longitudinal deformation and LV torsion remain impaired. We suggest including a detailed study of the diastolic function and cardiac mechanics in the clinical follow-up of these patients to identify the subgroup of patients at higher risk.

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Section: Discussionmentioning

confidence: 99%

“…LV torsion is the result of the contraction of the left-handed subepicardial fibers while the right-handed subendocardial myocardial fibers counteract this torsion [28,29]. In ALCAPA patients, LV torsion was significantly impaired.…”

Section: Discussionmentioning

confidence: 99%

Left Ventricular Mechanics in Patients with Abnormal Origin of the Left Main Coronary Artery from the Pulmonary Trunk Late after Successful Repair

Salvo

Siblini²,

Issa³

et al. 2016

Cardiology

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“…Six segments of the LV and septum were generated from apical 4‐chamber and short‐axis 2‐dimensional views (acquired at the mitral‐valve and apex levels) and averaged to determine global strain, strain rate, and displacement in the longitudinal, radial, and circumferential directions over 3 cardiac cycles using 2‐dimensional speckle tracking 17, 18, 21. Torsion was calculated as the difference between mitral and apical end‐systolic rotation (degrees) and normalized to both LV hypertrophy (wall thickness) and end‐diastolic chamber length as previously described 17, 22…”

Section: Methodsmentioning

confidence: 99%

Saxagliptin and Tadalafil Differentially Alter Cyclic Guanosine Monophosphate (cGMP) Signaling and Left Ventricular Function in Aortic‐Banded Mini‐Swine

Hiemstra

Lee

Chakir

et al. 2016

JAHA

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BackgroundCyclic guanosine monophosphate‐protein kinase G‐phosphodiesterase 5 signaling may be disturbed in heart failure (HF) with preserved ejection fraction, contributing to cardiac remodeling and dysfunction. The purpose of this study was to manipulate cyclic guanosine monophosphate signaling using the dipeptidyl‐peptidase 4 inhibitor saxagliptin and phosphodiesterase 5 inhibitor tadalafil. We hypothesized that preservation of cyclic guanosine monophosphate cGMP signaling would attenuate pathological cardiac remodeling and improve left ventricular (LV) function.Methods and ResultsWe assessed LV hypertrophy and function at the organ and cellular level in aortic‐banded pigs. Concentric hypertrophy was equal in all groups, but LV collagen deposition was increased in only HF animals. Prevention of fibrotic remodeling by saxagliptin and tadalafil was correlated with neuropeptide Y plasma levels. Saxagliptin better preserved integrated LV systolic and diastolic function by maintaining normal LV chamber volumes and contractility (end‐systolic pressure‐volume relationship, preload recruitable SW) while preventing changes to early/late diastolic longitudinal strain rate. Function was similar to the HF group in tadalafil‐treated animals including increased LV contractility, reduced chamber volume, and decreased longitudinal, circumferential, and radial mechanics. Saxagliptin and tadalafil prevented a negative cardiomyocyte shortening‐frequency relationship observed in HF animals. Saxagliptin increased phosphodiesterase 5 activity while tadalafil increased cyclic guanosine monophosphate levels; however, neither drug increased downstream PKG activity. Early mitochondrial dysfunction, evident as decreased calcium‐retention capacity and Complex II‐dependent respiratory control, was present in both HF and tadalafil‐treated animals.ConclusionsBoth saxagliptin and tadalafil prevented increased LV collagen deposition in a manner related to the attenuation of increased plasma neuropeptide Y levels. Saxagliptin appears superior for treating heart failure with preserved ejection fraction, considering its comprehensive effects on integrated LV systolic and diastolic function.

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“…Torsion has proven to be very useful for assessing the global function of the heart [82,83]. Several studies have shown its usefulness to display changes with age [84][85][86][87], hypertension [88], cardiomyopathy [89], obesity [90], and coronary heart disease [91][92][93].…”

Section: Figure 9 Dense Images With Radial Strain (Top Left) Circummentioning

confidence: 99%

Magnetic Resonance Imaging of Myocardial Deformation and Scarring in Coronary Artery Disease.

Kihlberg¹

2017

Linköping University Medical Dissertations

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Left Ventricular Torsion

Cited by 149 publications

References 48 publications

Left Ventricular Mechanics in Patients with Abnormal Origin of the Left Main Coronary Artery from the Pulmonary Trunk Late after Successful Repair

Left Ventricular Mechanics in Patients with Abnormal Origin of the Left Main Coronary Artery from the Pulmonary Trunk Late after Successful Repair

Saxagliptin and Tadalafil Differentially Alter Cyclic Guanosine Monophosphate (cGMP) Signaling and Left Ventricular Function in Aortic‐Banded Mini‐Swine

Magnetic Resonance Imaging of Myocardial Deformation and Scarring in Coronary Artery Disease.

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