Left ventricular structure and function in black normotensive type 2 diabetes mellitus patients

Aigbe, Igben F; Kolo, P.M.; Omotoso, Ayodele

doi:10.4103/1596-3519.93530

Cited by 12 publications

(12 citation statements)

References 22 publications

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“…In this study, LVDD occurred significantly more frequently in the diabetic groups with or without MCA compared with the controls (p < 0.001) and the prevalence of LVDD in both diabetic groups were within the range of 40 to 75% reported by studies done on normotensive diabetics within 16 and outside the country. 17 Grade 1 LVDD was the commonest, which was significantly more in the microalbuminuric than the normoalbuminuric group and was the only grade seen in the controls (p < 0.01).…”

Section: Discussionsupporting

confidence: 64%

“…17 Grade 1 LVDD was the commonest, which was significantly more in the microalbuminuric than the normoalbuminuric group and was the only grade seen in the controls (p < 0.01). Aigbe et al 16 and Patil et al 17 reported similar findings. Higher grades (2 and 3), although rare, were commoner in the microalbuminuric (8.5%) than the normoalbuminuric group (6.4%).…”

Section: Discussionmentioning

confidence: 55%

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Association of microalbuminuria with left ventricular dysfunction in Nigerian normotensive type 2 diabetes patients

Shogade

Essien

Ekrikpo

et al. 2018

CVJA

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Background: Diabetes mellitus (DM) is a risk factor for left ventricular (LV) dysfunction, and microalbuminuria is frequently associated with DM. This study aimed to compare LV function among normotensive type 2 diabetes (T2DM) patients with normoalbuminuria, those with microalbuminuria, and healthy controls. Methods: This was a cross-sectional study conducted at the diabetes and cardiology clinics of the

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 55%

Association of microalbuminuria with left ventricular dysfunction in Nigerian normotensive type 2 diabetes patients

Shogade

Essien

Ekrikpo

et al. 2018

CVJA

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“…In this study that focused on normotensive type 2 diabetics, we also observed that PWTd, IVSTd and LVID progressively increased from control group to microalbuminuric group, which resulted in the increased LVM, LVMI and RWT, thereby influencing the LV geometry remodeling. Diabetes has been implicated in the pathogenesis of cardiovascular abnormalities such as higher and lower LVM, more concentric left ventricular geometry remodeling and a lower myocardial function independent of age, sex, body size and arterial blood pressure [3,6,[21][22]. These cardiovascular abnormalities are known to predict higher rates of cardiovascular events in both asymptomatic and symptomatic subjects and also contribute in part to the high rates of coronary heart disease and heart failure observed among diabetic patients [23,24].…”

Section: Discussionmentioning

confidence: 99%

“…Diabetes mellitus (DM) is associated with diverse cardiovascular conditions such as myocardial infarction and heart failure (HF), which are the leading causes of diabetesrelated morbidity and mortality [1,2]. Previous studies elsewhere [3][4][5] and in Nigeria [6] have demonstrated left ventricular geometry remodeling and dysfunction in diabetics, supporting the existence of diabetic cardiomyopathy (DMCMP). The Framingham Heart Study showed that the frequency of HF is twice as high in diabetic men and five times higher in diabetic women compared with age-matched controls, and that this increased incidence of HF persisted despite correction for age, hypertension, obesity, hypercholesterolaemia and coronary artery disease (CAD) [7].…”

Section: Introductionmentioning

confidence: 99%

Association of Microalbuminuria with Abnormal Left Ventricular Geometry Patterns in Nigerian Normotensive Type 2 Diabetic Patients

Shogade¹

2019

EJPM

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To compare left ventricular (LV) geometry patterns among normotensive type 2 diabetics (NT2DM) with normoalbuminuria, NT2DM with microalbuminuria and healthy controls. A cross-sectional study conducted at the medical outpatient department of a Teaching Hospital from January 2013 to March 2014. Sixty-three normoalbuminuric NT2DM, 71 microalbuminuric NT2DM and fifty-nine healthy controls were recruited. Microalbuminuria was tested for using Micral test strips (Roche, Germany). Trans-thoracic echocardiography was carried out on all subjects. Relative wall thickness (RWT), left ventricular mass index (LVMI) and LV geometry patterns were compared among the three groups. The three groups were age and sex-matched and appropriate statistical tests were used for comparisons with p<0.05. The proportions of abnormal LV geometry (33.3% vs 71.4% vs 84.5%), LVMI and RWT showed a significant stepwise increase from healthy controls through normoalbuminuric NT2DM and to microalbuminuric NT2DM (all p<0.01). Concentric remodeling (CR) was the commonest pattern among the three groups. Left ventricular mass index and RWT correlated significantly with duration of DM and body mass index (all p< 0.01). Microalbuminuria showed a strong direct association with abnormal LV geometry (OR 3.27, 95% CI 1.63-6.57, p<0.01) while duration of DM was found to be an independent predictor of LV geometry remodeling (OR 1.23, 95% CI 1.02-1.49, p = 0.03) among normotensive diabetics. Although CR was the commonest pattern across the three patient groups, those with microalbuminuria had the highest proportion and risk of LV remodeling. Early screening and prompt treatment of microalbuminuria in NT2DM is hereby recommended.

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“…where IVSd is the left ventricular septal thickness diastole, LVIDd is the left ventricular internal dimension during diastole, and PWTd is the posterior wall thickness diastole (Aigbe et al 2012).…”

Section: Echocardiographic Proceduresmentioning

confidence: 99%

Age-associated alterations of cardiac structure and function in the female F344xBN rat heart

Fannin

Rice

Thulluri

et al. 2014

AGE

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The Fischer 344/NNiaHSD × Brown Norway/BiNia F1 (F344xBN) rat model exhibits an increased life span and fewer age-associated pathologies compared to commonly used Fischer 344 (F344). How aging may affect cardiac structure and function in these animals, has to our knowledge, not been investigated. Echocardiography was performed on female F344xBN rats at 6, 26, and 30 months of age using a Phillips 5500 Echocardiography system. Before sacrifice, electrocardiograms were measured in the female F344xBN in order to determine heart rhythm interval changes. Aging was associated with an increase in heart to body weight ratio, cardiomyocyte cross-sectional area, posterior wall thickening, and left ventricle chamber dilatation. Aging was associated with slight evidence of diastolic dysfunction. Alterations in heart rhythm intervals were associated with alterations in the spatial distribution of connexin 43. The incidence of arrhythmias was not different with age; however, valvular dysfunction was increased. These data suggest that aging in the female F344xBN rat heart is associated with changes in cardiac structure as well as function. Further investigation regarding other parameters of cardiac biochemistry and function is needed to better understand the normal compensated cardiovascular aging process in the female F344xBN.

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Left ventricular structure and function in black normotensive type 2 diabetes mellitus patients

Abstract: There is high prevalence of alterations in LV structure and function in normotensive type 2 DM; and there is a need for early intervention to prevent overt LV dysfunction.

Cited by 12 publications

References 22 publications

Association of microalbuminuria with left ventricular dysfunction in Nigerian normotensive type 2 diabetes patients

Association of microalbuminuria with left ventricular dysfunction in Nigerian normotensive type 2 diabetes patients

Association of Microalbuminuria with Abnormal Left Ventricular Geometry Patterns in Nigerian Normotensive Type 2 Diabetic Patients

Age-associated alterations of cardiac structure and function in the female F344xBN rat heart

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